DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and ears-1

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	NP_001366832.1	Gene:	ears-1 / 172904	WormBaseID:	WBGene00001337	Length:	1149	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	200/709 - (28%)
Similarity:	307/709 - (43%)	Gaps:	120/709 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 QSLNANIDLQALEKECGVGVVVTPEQIERTVQAKIKASYKE-ALLEQRYHF-------NSFKILQ 154
            |.|..|:|.:.|..:..:..::.  |......:.:.:|..: |:::...:|       |.:.:|.
Worm    41 QQLALNLDGELLSNDVEIARIIA--QSTDAADSLLGSSIIDFAVVDDLTNFIADAVTKNDYSLLL 103

  Fly   155 DVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQTKANDKPKAAKPKAEVTPAA-------- 211
            ......|..| .|:..| |..||.:      |...||.||.......|...|.|.||
Worm   104 GKDFPTKILD-NSLTVA-DFAIFSV------AHNNPQLKAKFSGIIDKVLKEPTLAAAHNFVGLY 160

  Fly   212 QTAEAASDGATTISELMKTKVHF-HAPGENFKADGYVVTEHTERLLKEHLARTGGKVHTRFPPEP 275
            ::|.|.:..|:|..|..|.:..| ..||             .|:          |||..|||||.
Worm   161 KSAAAPTATASTGKEKKKDEGKFVELPG-------------AEK----------GKVVVRFPPEA 202

  Fly   276 NGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWLGYKPFKITYSSD 340
            :|.||||||||..:|..|..|.:|...:|:|||||.||...|...|||.:..|...|.:.|:|||
Worm   203 SGYLHIGHAKAALLNQYYQQAFEGQLIMRFDDTNPAKENAHFEHVIKEDLSMLNIVPDRWTHSSD 267

  Fly   341 NFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPKPSPWRER---PIEESLRLFEDMKRGKIDEGA 402
            :|:.|......|:.:|.|:|.....|.::....:....|.|   | |::|:|:|:||:|......
Worm   268 HFEMLLTMCEKLLKEGKAFVDDTDTETMRNEREQRQDSRNRSNTP-EKNLQLWEEMKKGSPKGLT 331

  Fly   403 ATLRMKVTLE--EGKM-DPVAYRIKFISHHRTGSDWCIYPTYDYTHCLCDSLEDITHSLCTKEFQ 464
            ..:|||:.::  .|.| ||..||.|...|.|||..:.:|||||:|..:.||:|.:||:|.|.|:.
Worm   332 CCVRMKIDMKSNNGAMRDPTIYRCKPEEHVRTGLKYKVYPTYDFTCPIVDSVEGVTHALRTTEYH 396

  Fly   465 SRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQIVHDWDDPRLFTLTALRRRG 529
            .|...||::|:|||:..|..|||.||||...::||||:...:.|..|..||||||.|:..:.|||
Worm   397 DRDDQYYFICDALGLRRPHIWEYARLNMTNTVMSKRKLTWFVDEGHVEGWDDPRLPTVRGVMRRG 461

  Fly   530 FPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPR--RLVVLEPLKVTIKNFPHAAPVQ 592
            ...|.:..|....|.:.:.:.::...:.|..:.|::..|||  .|....||            |.
Worm   462 LTVEGLKQFIVAQGGSRSVVMMEWDKIWAFNKKVIDPVAPRYTALDSTSPL------------VS 514

  Fly   593 LEVPD-----------FPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVGLRHAGL 646
            :|:.|           .|:|.:.|:..:...|.:.:||.|                :..|:...:
Worm   515 IELTDSISDDTSNVSLHPKNAEIGSKDVHKGKKLLLEQVD----------------AAALKEGEI 563

  Fly   647 VISVD----EIVKDPATGQVVELICTSQPAEQAE-KPKAFVQWV-------SQPIQLEVRLYEQL 699
            |..|:    :|.|....|.|:..|..:...:..: |....|.|:       .:.|.:....|:.:
Worm   564 VTFVNWGNIKIGKIEKKGAVITKISATLQLDNTDYKKTTKVTWLGDVKAEAGKTIPVVTADYDHI 628

  Fly   700 FKHK---NPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERIGFFSVD 755
            ....   ..||..:.       |:..|:.......:.|:...|..|..|.:|.||:.||
Worm   629 ISKAIIGKDEDWKQF-------INFDSVHYTKMVGEPAIKNVKKGDIIQIQRKGFYIVD 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	200/709 (28%)
ears-1	NP_001366832.1	PLN02907	6..708	CDD:215492	200/709 (28%)
		S15_NS1_EPRS_RNA-bind	733..782	CDD:412325
		WEPRS_RNA	804..853	CDD:238473
		WEPRS_RNA	878..927	CDD:238473
		WEPRS_RNA	948..994	CDD:238473
		WEPRS_RNA	1017..1064	CDD:238473
		WEPRS_RNA	1089..1138	CDD:238473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820