Protein Alignment GlnRS and EARS2

DIOPT Version :9

• Sequence 1: NP_524841.1
• Gene: GlnRS / 45786
• FlyBaseID: FBgn0027090
• Length: 778
• Species: Drosophila melanogaster
• Sequence 2: NP_001295140.1
• Gene: EARS2 / 124454
• HGNCID: 29419
• Length: 534
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 97/432 - (22%)
• Similarity: 153/432 - (35%)
• Gaps: 133/432 - (30%)

  Fly   264 GGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWL 328
            |..|..||.|.|.|.||:|..:....|:.:|..:.|...||.:||:..:........|::|:||.
Human    34 GVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAENIEDMLEWA 98

  Fly   329 GYKPFKI--------TYSSDNFQQLYEWAV-VLINKGLAYVCH---QKAEELK------------ 369
            |..|.:.        .|......:||..|. .|:..|.||.|.   |:.|.||
Human    99 GIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRY 163

  Fly   370 ----------------GFNPKPSPWRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGKMDP 418
                            ..:|||: .|.| :|:.:..|:|:..|       ..|.:|...||  ||
Human   164 DNRCRNMSQEQVAQKLAKDPKPA-IRFR-LEQVVPAFQDLVYG-------WNRHEVASVEG--DP 217

  Fly   419 VAYRIKFISHHRTGSDWCIYPTYDYTHCLC---DSLEDITHSLCTKEFQSRRSSYYWLCNALGIY 480
            |..:          ||.  :|||   |..|   |....|:|.|...|:....:.:..|..|||
Human   218 VIMK----------SDG--FPTY---HLACVVDDHHMGISHVLRGSEWLVSTAKHLLLYQALG-- 265

  Fly   481 CPVQWEYGR-------LNMNYALVSKRKIAKLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNF 538
                |:...       ||.:.:.:|||: ..:..|....|               ||..:::.:.
Human   266 ----WQPPHFAHLPLLLNRDGSKLSKRQ-GDVFLEHFAAD---------------GFLPDSLLDI 310

  Fly   539 CAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRLVVLEPLKVTIKNFPHAAPVQLE-VPDFPQNP 602
            ....|...|:             :.:..|.|..:......:||.    |:|.:.|| :|:|
Human   311 ITNCGSGFAE-------------NQMGRTLPELITQFNLTQVTC----HSALLDLEKLPEF---- 354

  Fly   603 QQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVGLRHA 644
                :::.|.:::         ..|...|:|..|..|.:..|
Human   355 ----NRLHLQRLV---------SNESQRRQLVGKLQVLVEEA 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	97/432 (22%)
EARS2	NP_001295140.1	GluRS_core	36..361	CDD:173905	90/397 (23%)
		gltX	37..508	CDD:234953	96/429 (22%)
		Glutamate binding. /evidence=ECO:0000250	40..42		1/1 (100%)
		'HIGH' region	45..53		4/7 (57%)
		Glutamate binding. /evidence=ECO:0000250	228..232		2/6 (33%)
		'KMSKS' region	284..288		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810