DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GlnRS and eprs1

DIOPT Version :9

Sequence 1:	NP_524841.1	Gene:	GlnRS / 45786	FlyBaseID:	FBgn0027090	Length:	778	Species:	Drosophila melanogaster
Sequence 2:	XP_031758973.1	Gene:	eprs1 / 100145057	XenbaseID:	XB-GENE-966791	Length:	1708	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	211/788 - (26%)
Similarity:	345/788 - (43%)	Gaps:	123/788 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QALGMSEQKAKETLKNANVTKNLQLSLAAAG-SATLSDGTGMLIYHMATKLKPQ-----TADHLP 69
            |...:.|.:|..||.:     :.:..:|||| |::::.|..|.:....:...|.     |.:||.
Frog    16 QCWSVCEPEAGCTLSH-----SARSFVAAAGISSSIAGGDSMALTLTVSSSSPSLAVLWTVEHLK 75

  Fly    70 LLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANID-LQALEKECGVGVVVTPEQIERTVQAKIK 133
            ..::..|:...|...||...:.:     ..:::.:. |..|..:.|:......||.|
Frog    76 GQIQIHVQEGKDTHLRVTDTISF-----TDVHSIVRYLARLAPDKGLSGSHLTEQTE-------- 127

  Fly   134 ASYKEALLEQRYHFNSFKILQDVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQTKANDKP 198
                   :.....|:..|::|  :||.. ...:.:...:.:..:.:....|.||:
Frog   128 -------VSHWMEFSQTKLMQ--KGEFS-TGLQELNHCLSLRTYLVGNALTLADI---------- 172

  Fly   199 KAAKPKAEVTPAAQTAEAASD-------GATTISELMKTKVHFHAPGENF--KADGYVVTEHTER 254
                      ......||:|:       |.|.::  ::....|..|...|  :.:..|.:|..:.
Frog   173 ----------CVFSALEASSEWQALVQKGQTPVN--VRRWYSFLEPQLGFWSRTNNKVPSEKKQD 225

  Fly   255 LLK--EHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKF 317
            :.|  |......|||..|||||.:|.||||||||..:|..|.....|...:|:||||||||:|.|
Frog   226 VGKFVELPGAEMGKVIVRFPPEASGYLHIGHAKAALLNQHYQVTFKGKLIMRFDDTNPEKEKEDF 290

  Fly   318 FLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPK--PSPWRE 380
            ...|.|.|..|..||.:.||:||:|..:.::|..||.:|.|||....||::|....:  .|..|.
Frog   291 EKVILEDVSMLQIKPDQFTYTSDHFDTIMKYAEKLIQEGKAYVDDTPAEQMKSEREQRIESKHRS 355

  Fly   381 RPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGK---MDPVAYRIKFISHHRTGSDWCIYPTYD 442
            ..:.:::.::||||:|........||.|:.:....   .||..:|.|...|.||||.:.||||||
Frog   356 NTVAKNMEMWEDMKKGTEYGQTCCLRAKIDMNSNNGCMRDPTLFRCKNQPHPRTGSKYNIYPTYD 420

  Fly   443 YTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLIT 507
            :...:.||:|.:||:|.|.|:..|...:||:.:||||..|..|||.|||:|..::|||::...:.
Frog   421 FACPIVDSVEGVTHALRTTEYHDRDEQFYWIIDALGIRKPYIWEYSRLNLNNTVLSKRRLTWFVN 485

  Fly   508 EQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRL 572
            |.:|..|||||..|:..:.|||...|.:..|.|..|.:.:.:.::...:.|..:.|::..|||..
Frog   486 EGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYS 550

  Fly   573 VVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQ 637
            .:|:...|.: |.|.|....:||...|:|.:.|...:.....:.||..|.:        .|:..:
Frog   551 ALLKSQAVAV-NIPDAKEGMVEVAKHPKNAEVGQKPVWYGPKVLIEGADAE--------TLSEGE 606

  Fly   638 SVGLRHAGLVISVDEIVKDPATGQVVELIC-----------TSQPAEQAEKPKA---------FV 682
            :|...:.|.:| :.:|.:| .:|::..|..           |::....||.|||         :.
Frog   607 TVTFINWGNLI-ITKIHRD-QSGKIQSLDAKLNLENKDYKKTTKITWLAETPKAPFIPTSCVNYD 669

  Fly   683 QWVSQPIQLEVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFE 747
            ..:::|:         |.|.::          |...::..|....|...|..|...|..|..|.:
Frog   670 HLITKPV---------LGKEED----------FKQYVNRSSKQEEVMLGDPCLKDLKKGDLIQLQ 715

  Fly   748 RIGFFSVD 755
            |.||:..|
Frog   716 RRGFYICD 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GlnRS	NP_524841.1	PLN02859	10..777	CDD:178450	211/788 (27%)
eprs1	XP_031758973.1	PLN02907	52..753	CDD:215492	200/747 (27%)
		WEPRS_RNA	798..847	CDD:238473
		WEPRS_RNA	869..916	CDD:238473
		WEPRS_RNA	944..992	CDD:238473
		WEPRS_RNA	1024..1073	CDD:238473
		WEPRS_RNA	1104..1152	CDD:238473
		PRK08661	1215..1708	CDD:236327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010