DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS and ILS1

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_009477.1	Gene:	ILS1 / 852202	SGDID:	S000000172	Length:	1072	Species:	Saccharomyces cerevisiae

Alignment Length:	1088	Identity:	531/1088 - (48%)
Similarity:	738/1088 - (67%)	Gaps:	35/1088 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYA 80
            :.:||.|||.||..|...:.|....:|:|.||:::|:||||||||.||||||||.||||||.|||
Yeast     7 HFSFPKEEEKVLSLWDEIDAFHTSLELTKDKPEFSFFDGPPFATGTPHYGHILASTIKDIVPRYA 71

  Fly    81 YQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENVVTR 145
            ...|:||:||||||.||:|:|..|||.|.|.|.:||.|.|:..||.|||.|||.||.:|...:.|
Yeast    72 TMTGHHVERRFGWDTHGVPIEHIIDKKLGITGKDDVFKYGLENYNNECRSIVMTYASDWRKTIGR 136

  Fly   146 VGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYKEVV 210
            :||||||.|||||:||.:|||.||.||||.:||.||:|.|||||||..||.||||||.||||:|.
Yeast   137 LGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQVYRGFKVMPYSTGLTTPLSNFEAQQNYKDVN 201

  Fly   211 DPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRLSYVY 275
            ||.|.:....:....|..:.|||||||||||.:.||:....|||:.|...||.|:|.||.:..:|
Yeast   202 DPAVTIGFNVIGQEKTQLVAWTTTPWTLPSNLSLCVNADFEYVKIYDETRDRYFILLESLIKTLY 266

  Fly   276 K--SETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFG 338
            |  ...:|::.||..|..|..|.|:|||||||::..|. |:||:.|:|||.|||||||||||.||
Yeast   267 KKPKNEKYKIVEKIKGSDLVGLKYEPLFPYFAEQFHET-AFRVISDDYVTSDSGTGIVHNAPAFG 330

  Fly   339 EDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVK 403
            |:|...||..|:|::.|.:...:|:.||||.:..||||.||||:||.|:..|...|||:.:.|::
Yeast   331 EEDNAACLKNGVISEDSVLPNAIDDLGRFTKDVPDFEGVYVKDADKLIIKYLTNTGNLLLASQIR 395

  Fly   404 HSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAISR 468
            |||||||||||||:|::||:|||||:::...:||...:::|||:.:|||||.||:..||||.:||
Yeast   396 HSYPFCWRSDTPLLYRSVPAWFVRVKNIVPQMLDSVMKSHWVPNTIKEKRFANWIANARDWNVSR 460

  Fly   469 NRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQ-VEDLHRESIDHIEIPSAVPGNPPLRRIAP 532
            |||||||||:|.|...:|.|.:||||:|.||:||: :.||||:.||.:.|||. .|...|:||..
Yeast   461 NRYWGTPIPLWVSDDFEEVVCVGSIKELEELTGVRNITDLHRDVIDKLTIPSK-QGKGDLKRIEE 524

  Fly   533 VFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNL 597
            ||||||||||||:|.||:||||.:.|....||:||:||:||||||||||.|:.|.||...|:||:
Yeast   525 VFDCWFESGSMPYASQHYPFENTEKFDERVPANFISEGLDQTRGWFYTLAVLGTHLFGSVPYKNV 589

  Fly   598 IASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDIIKDV 662
            |.||:||||||:||||..||||||..|::||||||||||||||||::||||:||||||::::..|
Yeast   590 IVSGIVLAADGRKMSKSLKNYPDPSIVLNKYGADALRLYLINSPVLKAESLKFKEEGVKEVVSKV 654

  Fly   663 FLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFATEM 727
            .|||:|:::||...|...:|   ..|..:.||     .::...:|:|.|||:..:||::|...||
Yeast   655 LLPWWNSFKFLDGQIALLKK---MSNIDFQYD-----DSVKSDNVMDRWILASMQSLVQFIHEEM 711

  Fly   728 KMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYL 792
            ..|:||||||:|..|||:|||||:|.||||:|||.|.:.|:::|::|:|.|:|.|:.||||||:|
Yeast   712 GQYKLYTVVPKLLNFIDELTNWYIRFNRRRLKGENGVEDCLKALNSLFDALFTFVRAMAPFTPFL 776

  Fly   793 TEYIFQRLVLFQPAGTL----EHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRR 853
            :|.|:.||..:.|...|    :...|||:...||.:|::....||.:|:.||||::|||.:|:::
Yeast   777 SESIYLRLKEYIPEAVLAKYGKDGRSVHFLSYPVVKKEYFDEAIETAVSRMQSVIDLGRNIREKK 841

  Fly   854 TLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQR 918
            |:.:|.|:..::.:|.|...|:.::.|:::|:.|||||.:.::||:.||||..:|..|...||::
Yeast   842 TISLKTPLKTLVILHSDESYLKDVEALKNYIIEELNVRDVVITSDEAKYGVEYKAVADWPVLGKK 906

  Fly   919 LKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRI---ELDEVRIIYCTSEQVGGNFEAHSDNE 980
            ||.:.|.|..|:.::..:::::.:..|..::....:   :|:.:|.:..::.|.|.  |..:|.:
Yeast   907 LKKDAKKVKDALPSVTSEQVREYLESGKLEVAGIELVKGDLNAIRGLPESAVQAGQ--ETRTDQD 969

  Fly   981 VLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLA 1045
            ||:::|.....||..||||||::||:|||:||..|..||.||:.:||..|      .::.:|
Yeast   970 VLIIMDTNIYSELKSEGLARELVNRIQKLRKKCGLEATDDVLVEYELVKD------TIDFEA--- 1025

  Fly  1046 KVLSNYASIIKTAIKSEFAPYSSEQASKKRLIASELVDLKGVPLKLTI 1093
             ::..:..::....:|:.|.|   ..||...|..|...:.....||.:
Yeast  1026 -IVKEHFDMLSKTCRSDIAKY---DGSKTDPIGDEEQSINDTIFKLKV 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	531/1088 (49%)
		IleRS_core	47..>189	CDD:173909	92/141 (65%)
		IleRS_core	<373..650	CDD:173909	173/277 (62%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	87/200 (44%)
ILS1	NP_009477.1	PLN02882	8..1037	CDD:215477	522/1050 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345979
Domainoid	1	1.000	747	1.000	Domainoid score	I7
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1051	1.000	Inparanoid score	I22
Isobase	1	0.950	-	0	Normalized mean entropy	S440
OMA	1	1.010	-	-		QHG60783
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto99643
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1443
SonicParanoid	1	1.000	-	-		X3282
TreeFam	0	0.000	Not matched by this tool.
	15	14.780