DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS and AT4G10320

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_192770.2	Gene:	AT4G10320 / 826624	AraportID:	AT4G10320	Length:	1190	Species:	Arabidopsis thaliana

Alignment Length:	1196	Identity:	586/1196 - (48%)
Similarity:	762/1196 - (63%)	Gaps:	103/1196 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DVCRVPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIK 73
            :||...| .:||.:||:||..|...:.|:...:.::..|:|.|||||||||||||||||||||||
plant     3 EVCEGKE-FSFPRQEEDVLSFWTEIDAFKTQLKRTENLPEYIFYDGPPFATGLPHYGHILAGTIK 66

  Fly    74 DIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADE 138
            ||||||....|:||.|||||||||||||.|||:.||||..::|.||||..||.|||.||.||..|
plant    67 DIVTRYQTMTGHHVTRRFGWDCHGLPVENEIDRKLNIKRRDEVIKMGIDKYNEECRSIVTRYVAE 131

  Fly   139 WENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEAN 203
            ||.|:||.||||||||||||:...:|||:||:|.||::|.|||:|.|||||||.|.|.||||||.
plant   132 WEKVITRCGRWIDFKNDYKTMDLPFMESVWWVFSQLWEKNLVYRGFKVMPYSTGCKTPLSNFEAG 196

  Fly   204 QNYKEVVDPCVVVALEAV-SLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLA 267
            ||||||.||.::|....: ...|..|:.|||||||||||.|.||:....|||||:..:.:::::|
plant   197 QNYKEVPDPEIMVTFPVIGDQDNAAFVAWTTTPWTLPSNLALCVNAKFVYVKVRNKNTGKVYIVA 261

  Fly   268 ESRLSYV--------------------------YKSET---EYEVKEKFVGKTLKDLHYKPLFPY 303
            |||||.:                          .|.|:   .|||.|||.|.:|....|:|||.|
plant   262 ESRLSALPTDKPKAKLSNGPAGDTKKANPKAKGAKPESAADSYEVLEKFNGASLVGKKYEPLFDY 326

  Fly   304 FAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFT 368
            |:...:|  |:||:.|:|||:||||||||.||.||||||||||...:|.|...::..||:.|.||
plant   327 FSDFSSE--AFRVVADDYVTDDSGTGIVHCAPAFGEDDYRVCLLNKIIKKGENLVVAVDDDGLFT 389

  Fly   369 NEASDFEGQYVKDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSK 433
            ...:.|.|:||||:||.|:.|:||:|.||.:|...|||||||||||||||:||||||||||.:.:
plant   390 ERITHFSGRYVKDADKDIIEAVKAKGRLVKTGSFTHSYPFCWRSDTPLIYRAVPSWFVRVEQLKE 454

  Fly   434 NLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAE 498
            .||..:.||.|||.:||:|||.|||:.||||||||:|:||||:|||.|..|:|.|::.|:::|.:
plant   455 KLLKSNEQTEWVPGYVKDKRFHNWLENARDWAISRSRFWGTPLPIWISDDGEEVVIMDSVEKLEK 519

  Fly   499 LSGVQVEDLHRESIDHIEIPSAVPGNP--PLRRIAPVFDCWFESGSMPFAQQHFPFENEKDFMNN 561
            ||||:|.||||..||||.|||: .|:.  .|||:..||||||||||||:|..|:||||::.|..|
plant   520 LSGVKVFDLHRHHIDHITIPSS-RGDEFGVLRRVEDVFDCWFESGSMPYAYIHYPFENKELFEKN 583

  Fly   562 FPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVH 626
            ||.||:|||:||||||||||:|:|||||.|..|||||.:|||||.||:||:|:.:|||.|:||:.
plant   584 FPGDFVAEGLDQTRGWFYTLMVLSTALFEKPAFKNLICNGLVLAEDGKKMAKKLRNYPPPLEVID 648

  Fly   627 KYGADALRLYLINSPVVRAESLRFKEEGVRDIIKDVFLPWYNAYRFLLQNIVRYEKE-------- 683
            :|||||:|||||||||||||.||||:|||..::||||||||||||||:||..|.|.|
plant   649 EYGADAVRLYLINSPVVRAEPLRFKKEGVLGVVKDVFLPWYNAYRFLVQNAKRLETEGGVPFVPT 713

  Fly   684 DLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFATEMKMYRLYTVVPRLTKFIDQLTN 748
            |||              .:..|:::|.||.|..:||:.|...||..||||||||||.||:|.|||
plant   714 DLA--------------TIQSANILDQWIHSATQSLVRFVREEMDAYRLYTVVPRLLKFLDNLTN 764

  Fly   749 WYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHAD 813
            .|||.||:|:||..|.|.|..:|.||::||.|..|:||||||:.||.::|.|    ........:
plant   765 IYVRFNRKRLKGRTGEDDCHTALSTLFNVLLTSCKVMAPFTPFFTETLYQNL----RKACKGSEE 825

  Fly   814 SVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIK 878
            ||||..:| .::......||.||..|..:::|.|.:|:|..||:|.|:.|:|.:|.|:..|..|.
plant   826 SVHYCSIP-PREGMEGERIELSVTRMMKIIDLARNIRERNKLPLKTPLKEMIVVHPDADFLNDIT 889

  Fly   879 -TLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQV 942
             .|::::|.|||||.|...:|..|| .:|:||||...||:||..:...|...:|.:...:|....
plant   890 GVLREYVLEELNVRSLVPCNDTLKY-ASLKAEPDFSVLGKRLGKSMGLVAKEVKEMSQKDILAFE 953

  Fly   943 SQGYFDILDQRIELDEVRI--IYCTSEQVGGN-FEAHSDNEVLVLLDMTPNEELLEEGLAREVIN 1004
            ..|...|.:..::..:::|  ::...:.:..| .::..|.:|||:||:..::.|:|.|.|||::|
plant   954 EAGEVTIANHLLKETDIKIVRVFKRPDDLKENEIDSAGDGDVLVILDLRADDSLVEAGFAREIVN 1018

  Fly  1005 RVQKLKKKAQLIPTDPV-LIFHELAADNKAKQEVLEAQAQLAKVLSNYASIIKTAIKSEFAPYSS 1068
            |:|||:||:.|.|||.| :.|..|..|....::||.:|.|..|     .||..|.:.|...|
plant  1019 RIQKLRKKSGLEPTDFVEVYFQSLDEDESVSKQVLVSQEQNIK-----DSIGSTLLLSSLMP--- 1075

  Fly  1069 EQASKKRLIASELVDLKGVPLKLTICSTEELQLPNLPWLN--ISLAEDLVPRFGNSSKASLFLQH 1131
               |...:||.|....|         .|.:..:..:|.|:  ||||.   |....:.:|.|.|..
plant  1076 ---SHAVIIADETFTPK---------ETSDESVKKVPKLSYKISLAR---PALKFNEEAVLALYS 1125

  Fly  1132 NVSKEIISLPT---------LRSELE 1148
            ...|....|.|         |:||.:
plant  1126 GDVKSATGLQTYLLSRDHSNLKSEFQ 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	569/1129 (50%)
		IleRS_core	47..>189	CDD:173909	102/141 (72%)
		IleRS_core	<373..650	CDD:173909	182/278 (65%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	92/204 (45%)
AT4G10320	NP_192770.2	PLN02882	3..1186	CDD:215477	586/1196 (49%)
		nt_trans	40..>182	CDD:294020	102/141 (72%)
		IleRS_core	<436..672	CDD:173909	155/236 (66%)
		Anticodon_Ia_Ile_ABEc	672..858	CDD:153415	92/204 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	478	1.000	Domainoid score	I86
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1073	1.000	Inparanoid score	I32
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D59501at2759
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto3206
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880