Protein Alignment IleRS and ValRS

DIOPT Version :9

• Sequence 1: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Sequence 2: NP_001260946.1
• Gene: ValRS / 45783
• FlyBaseID: FBgn0027079
• Length: 1055
• Species: Drosophila melanogaster
• Alignment Length: 1138
• Identity: 250/1138 - (21%)
• Similarity: 393/1138 - (34%)
• Gaps: 299/1138 - (26%)

  Fly    30 WRHENIF-EKCSQLSKGKP----KYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDR 89
            |..|..| .:..:.|...|    |:.....||..||..|.||.|...|:|.:|||...:|.....
  Fly   107 WEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLW 171

  Fly    90 RFGWDCHGLPVEFEIDKLL--NIKGPEDVAKMGIAAYNAECRKIVMRYADEWE--------NVVT 144
            ..|.|..|:..:..::|||  :.|         ::.::....|.:.|..| |.        ..:.
  Fly   172 VPGCDHAGIATQVVVEKLLWRDEK---------LSRHDLGREKFIERIWD-WRREKGGRIYEQLK 226

  Fly   145 RVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYKEV 209
            .:|...|:.....|:.|....::...|.:|.::|.:|:..:::.:|....:::|:.|
  Fly   227 SLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIE-------- 283

  Fly   210 VDPCVVVALEAVSLPNTFFLVWTTTPWTLPS-----NFACCVHPTMTYVKVRDVKSDRLFVLAES 269
                    ::.|.:|...||       ::|.     .|...:  ...| ||..  ||...::|.:
  Fly   284 --------VDKVEIPGRTFL-------SIPGYEDKVEFGVLI--KFAY-KVEG--SDEEIIVATT 328

  Fly   270 RLSYVYKSETEYEVKEKFVGKTLKDLH-----YKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTG 329
            |:             |..:|.|...:|     ||.|...|.......:...::.||:|....|||
  Fly   329 RI-------------ETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTG 380

  Fly   330 IVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKA-- 392
            .|...|....:||.|.....|     ..:...::.|....:..:|.|....:..|:|:..|||
  Fly   381 AVKITPAHDPNDYEVGKRCNL-----PFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALN 440

  Fly   393 --RGNLVSSGQVKHSYPFCWRSD---TPLIYKAVPSWFVRVEHMSKNLLDC--SSQTYWVPDFVK 450
              |..|.:...|    |.|.||.   .|||   .|.|:|....|:.:..:.  |.:...:|:. .
  Fly   441 LYRETLNNPMVV----PICSRSKDVVEPLI---KPQWYVSCSDMAASATEAVRSGELKIIPEH-H 497

  Fly   451 EKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGS----------------------I 493
            .|.:.:|:...|||.:||..:||..||.:.....|.::..||                      :
  Fly   498 TKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEAL 562

  Fly   494 KQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRIAPVFDCWFESGSMPFAQQHFPFENEKDF 558
            .:.||..||....:                  .|::...|.|.||.||..||:...:| :..||.
  Fly   563 TKAAERFGVDASKI------------------VLKQDEDVLDTWFSSGIFPFSVFGWP-DQTKDL 608

  Fly   559 MNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPME 623
            ...:|...:..|.|....|...::.....|..|.|||.:....:|..|.|:||||...|..|||:
  Fly   609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMD 673

  Fly   624 VVHKYGADALRLYLINS----------------------PVVRAESLRFK----EEGVRDIIKDV 662
            |:.....:.|...|:.|                      |...:::|||.    ....|||..|:
  Fly   674 VIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDI 738

  Fly   663 FLPWYN---AYRFL---LQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLE 721
                 |   .|||.   |.|..::..  |...|...:|.|  |......:.:|.||||...:.:|
  Fly   739 -----NRVLGYRFFCNKLWNATKFAL--LYFTGSEKFDTE--LSASAAINQMDAWILSRLAAAIE 794

  Fly   722 FFATEMKMYRLYTVVPRLTKF-IDQLTNWYVRLNRRRIKGELGADQCIQSL-------------D 772
            ...|..:.|...........| :..|.:.|:              :|::.:             .
  Fly   795 ACNTGFESYDFAAATSACYAFWLYDLCDVYL--------------ECLKPIFQSGSEEQQTAARR 845

  Fly   773 TLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADSVHYQMMPVSQKKFIRNDIERSVA 837
            |||..|...:::::||.|::||.::|||....|      |.|:.....| |...:....||..|.
  Fly   846 TLYVCLDYGLRLLSPFMPFITEELYQRLPRANP------APSICVASYP-SNTSWRSTKIESDVE 903

  Fly   838 LMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKY 902
            .:|....:.|..|....||.|.. :|:..:..||...|.:|
  Fly   904 FVQKAARIIRSARSDYNLPNKVK-TEVYIVCTDSVPSEILK------------------------ 943

  Fly   903 GVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSE 967
                               .:.:.:|.|....:........||                  |...
  Fly   944 -------------------RYASDLATISYCSNVVFDSPAPQG------------------CAIL 971

  Fly   968 QVGGNFEAHSDNEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKA-QLIPTDPVLIFHELAAD- 1030
            .|.|..|.|                ||.:||. |....:.||:||: ||:.|...|.....|||
  Fly   972 TVTGQCEVH----------------LLLKGLV-EADKEIAKLQKKSDQLVQTVGKLTQAIQAADY 1019

  Fly  1031 -NKAKQEVLEAQAQLAKVLSNYASIIKTAIKSE 1062
             .|...||.||..  .|:..:.|.|.:.|...|
  Fly  1020 ATKVPAEVQEANE--TKLCESRAEIERIAAAIE 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	250/1138 (22%)
		IleRS_core	47..>189	CDD:173909	35/155 (23%)
		IleRS_core	<373..650	CDD:173909	79/329 (24%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	49/220 (22%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	250/1138 (22%)
		ValRS_core	129..736	CDD:185677	155/689 (22%)
		tRNA-synt_1_2	307..436	CDD:290334	32/151 (21%)
		Anticodon_Ia_Val	736..873	CDD:153416	34/159 (21%)
		Val_tRNA-synt_C	978..1053	CDD:287436	28/92 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840