DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS and Iars2

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	XP_038947424.1	Gene:	Iars2 / 364070	RGDID:	1311857	Length:	1012	Species:	Rattus norvegicus

Alignment Length:	991	Identity:	285/991 - (28%)
Similarity:	430/991 - (43%)	Gaps:	168/991 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DVCRVPENINFPAEEENVLQKWRHENIFEKC--SQL------SKGKPKYTFYDGPPFATGLPHYG 65
            |...:|:. |||.:.....|......|.:||  |:|      .|.|.::..:||||:|.|.||.|
  Rat    62 DTVLLPQT-NFPMKLLGHQQSDMELEIQQKCGFSELYSWQRERKVKTEFCLHDGPPYANGDPHVG 125

  Fly    66 HILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRK 130
            |.|...:||||.|:...:|..|....||||||||:|.::...|.: ..:.::.|.|   ..:.|.
  Rat   126 HALNKILKDIVNRFHMMRGSKVHFVPGWDCHGLPIETKVLSELGV-NTQTLSAMEI---REKARS 186

  Fly   131 IVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTT 195
            ......::.::...|.|...|:.|.|.|..|.|......:|:|:::|||||:..|.:.:|.:..|
  Rat   187 FAQAAIEKQKSAFARWGVMADWSNCYYTFDPKYEAKQLRVFQQMYEKGLVYRSYKPVYWSPSSRT 251

  Fly   196 SLSNFEANQNYKEVVDPCVVVALEAVSLPNTF-----------FLVWTTTPWTLPSNFACCVHPT 249
            :|:..|...| .|.|...|.|....:..|.|.           .|||||.|||:|:|.|.|..|.
  Rat   252 ALAEAELEYN-PEHVSRSVYVRFPLLKPPPTLESLTGASSPVSALVWTTQPWTVPANQAICYMPE 315

  Fly   250 MTYVKVRDVKSDRLFVLAESRLSYVYKS-ETEYEVKEKFVGKTLKD---LHYKPLFPYFAKRGAE 310
            ..|..|:...|...::|||.::|.|..: ||.::|...|.|..|:.   .|  ||.|
  Rat   316 AKYAVVKCSASGNFYILAEDKISPVASALETTFDVTATFSGVDLEGGTCSH--PLIP-------- 370

  Fly   311 VKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEAS-DF 374
            .|...:|...:||...|||:||.||..|.:||.|.....|     .:.|.|||.|.||:.|. :.
  Rat   371 DKVSPLLPATHVTMAKGTGLVHTAPAHGMEDYSVASQHSL-----PMDCLVDEEGMFTSAAGPEL 430

  Fly   375 EGQYV-KDSDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDC 438
            :.:.| .:....::..|:|..||:....:.||||..||:..|::.:|...|||.:..:.....:.
  Rat   431 QNKAVLTEGTDVVIKMLQATKNLLKEESIVHSYPCDWRTKKPVLIRASKQWFVNIMDIKATAKES 495

  Fly   439 SSQTYWVPDFVKEKRFGNWLKEARD-------WAISRNRYWGTPIPIWRSPSGDETVVIGS---- 492
            .....::|        |..|....|       |.|||.|.||.|||::...:.||.::...
  Rat   496 LKTVKFIP--------GAALNSMMDMLDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEH 552

  Fly   493 IKQLAELSGVQV------EDLHRESIDHIEIPSAVPGNPPLRRIAP---VFDCWFESGS-----M 543
            |.:|.|..|..|      |.|..|.:      .|..|.|......|   :.|.||:||:     :
  Rat   553 IIKLVEQHGSDVWWTLPAEKLLPEEV------VAQAGGPGALEYVPGQDILDIWFDSGTSWSCVL 611

  Fly   544 PFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADG 608
            ...:|.              ||...||.||..|||.:.|:.|.|..:||||:.::..|..|...|
  Rat   612 QGTEQR--------------ADLYLEGKDQLGGWFQSSLLTSVATRSKAPFRTVMVHGFTLGEKG 662

  Fly   609 QKMSKRKKNYPDPMEVV-----HK----YGADALRLYLINSPVVRAESLRFKE----EGVRDIIK 660
            :||||...|..||..::     |.    ||||.||.::       |||..|.|    ..|....:
  Rat   663 EKMSKSLGNVIDPDTIISGGKDHSKEPPYGADILRWWI-------AESNVFTEVTIGPSVLSAAR 720

  Fly   661 DVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFAT 725
            |......|..||||.|:..:..|..:          ..:|||   .:||.::|    .|::.|||
  Rat   721 DDISKLRNTLRFLLGNLAGFNPETAS----------VPVKNM---YIIDQYML----HLIQDFAT 768

  Fly   726 EM----KMYRLYTVVPRLTK--FIDQLTNWYVRLNRRRIKGELGADQCIQSLDT-LYDVLYTMVK 783
            ::    |.|....|| ||.|  :..:|:::|..:.:.|:..|...|...:|..| |.::|..:|:
  Rat   769 KVTDSYKQYDFGKVV-RLLKAFYTRELSSFYFSIVKDRLYCESETDPKRRSCQTALAEILDVLVR 832

  Fly   784 MMAPFTPYLTEYIFQRLVLFQPAGTLEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRV 848
            ..||..|:|.|.:||.:...:...::.....:  ....|.:|..:...:|.:.|:..|.  ||
  Rat   833 SFAPVLPHLAEEVFQHIPYVKEPKSVFRTGWI--STSSVWKKPGLEEAVESACAMRDSF--LG-- 891

  Fly   849 MRDRRTLPVK----YPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRA- 908
                 ::|.|    |.|..:|......:|:|.::..:....|:||  :|.::|.     .||.|
  Rat   892 -----SIPGKNAAEYDVIIVIEPGLLFEIMEMLQAEETSSTSQLN--ELMMASQ-----TTLLAQ 944

  Fly   909 EP-DHKALGQRLKGNF 923
            || :..|....|.|.|
  Rat   945 EPRERSADAIELTGTF 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	285/991 (29%)
		IleRS_core	47..>189	CDD:173909	47/141 (33%)
		IleRS_core	<373..650	CDD:173909	86/311 (28%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	51/207 (25%)
Iars2	XP_038947424.1	ileS	60..1009	CDD:235588	285/991 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930