DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS and iars1

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_956190.2	Gene:	iars1 / 334393	ZFINID:	ZDB-GENE-030131-6325	Length:	1271	Species:	Danio rerio

Alignment Length:	1253	Identity:	680/1253 - (54%)
Similarity:	890/1253 - (71%)	Gaps:	80/1253 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVT 77
            |||:|:||.|||.:||.|:..:.|::|.:.||.:|::||||||||||||||||||||||||||||
Zfish     5 VPESIHFPTEEEQILQFWQKNDCFQECLKQSKSRPRFTFYDGPPFATGLPHYGHILAGTIKDIVT 69

  Fly    78 RYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENV 142
            |:|:|.|:||:|||||||||||||:||||.|||||||||.||||..||.:||.|||||||||||.
Zfish    70 RFAHQNGFHVERRFGWDCHGLPVEYEIDKSLNIKGPEDVMKMGIEEYNKQCRSIVMRYADEWENS 134

  Fly   143 VTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYK 207
            |.|:||||||:|||||||||:||::||:||||:|.||||:||||||:||||.|.|||||||||||
Zfish   135 VRRMGRWIDFRNDYKTLYPWFMETVWWVFKQLYDSGLVYRGVKVMPFSTACNTPLSNFEANQNYK 199

  Fly   208 EVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRLS 272
            :|.||.|:|....:..|:...:.|||||||||||.|.||:|.:.||:|:|..|.:::::.|:||.
Zfish   200 DVQDPSVIVNFPLLEDPSVSLIAWTTTPWTLPSNLALCVNPELIYVRVKDNSSQKIYIMMEARLV 264

  Fly   273 YVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYF 337
            .::||::||.:.|:|.|||||...|||||.||.| ..|..|:.|::|.||.:|.|||:||.||||
Zfish   265 ALFKSDSEYTILERFPGKTLKGKKYKPLFEYFIK-CKETGAFSVVMDNYVRDDDGTGVVHQAPYF 328

  Fly   338 GEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQV 402
            |.||||||:...:|.:.|..:||||.:|.||.|.:.|.||||||:||.|:..||..|.|||:...
Zfish   329 GADDYRVCMEYDIIQRDSAPICPVDPSGIFTPEVTHFAGQYVKDADKNIIKWLKENGRLVSASSF 393

  Fly   403 KHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAIS 467
            |||||||||||||||||||||||:|||||.:.|||.:|:.||||:|||||||||||::|||||:|
Zfish   394 KHSYPFCWRSDTPLIYKAVPSWFIRVEHMVEKLLDNNSKCYWVPEFVKEKRFGNWLRDARDWAVS 458

  Fly   468 RNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRIAP 532
            ||||||||||:|.|...:|.|.:||:.:|.||:|::|.||||||||.:.|||.. |...|||::.
Zfish   459 RNRYWGTPIPLWVSDDFEEVVCVGSMAELEELTGIKVTDLHRESIDGLTIPSRC-GKGQLRRVSE 522

  Fly   533 VFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNL 597
            ||||||||||||:||.|:||||.::|.:.||||||||||||||||||||||:|||||.|.||||:
Zfish   523 VFDCWFESGSMPYAQVHYPFENRREFEDAFPADFIAEGIDQTRGWFYTLLVLSTALFGKPPFKNV 587

  Fly   598 IASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDIIKDV 662
            |.:|||||:|||||||||||||||..:|..|||||||||||||||||||:||||||||||::|||
Zfish   588 IVNGLVLASDGQKMSKRKKNYPDPGLIVQSYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDV 652

  Fly   663 FLPWYNAYRFLLQNIVRYEKEDLAGNGQYTY-DRERHLKNMDKASVIDVWILSFKESLLEFFATE 726
            |||||||||||:||:.|.:||:   ..::.| :|...:.|    :::|.||.||.:||::||..|
Zfish   653 FLPWYNAYRFLVQNVQRLQKEE---GVEFLYNERTSSVSN----NIMDKWIQSFTQSLIQFFRDE 710

  Fly   727 MKMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPY 791
            |..||||||||:|.||:|.|||||||:||||:|||.|::.|:::|:||:.||::|.::||||||:
Zfish   711 MGAYRLYTVVPKLVKFVDMLTNWYVRMNRRRLKGESGSEDCVRALETLFSVLFSMCRLMAPFTPF 775

  Fly   792 LTEYIFQRL-VLFQPAGTLEHAD--SVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRR 853
            :||.::|.| .|..|| .:|..|  |:||.|:|..::..|...||.:|:.||||:|||||:|||:
Zfish   776 ITELMYQNLRHLLDPA-AVEEKDTGSIHYLMLPQVRESLIDQRIESAVSRMQSVIELGRVIRDRK 839

  Fly   854 TLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQR 918
            |||:|||:.|::.||:|.:.|..|::||::||.|||||:||||:||::||:.|||||||..||:|
Zfish   840 TLPIKYPLKEVVVIHQDPEALTDIQSLQNYILEELNVRQLTLSTDKDRYGIRLRAEPDHMVLGKR 904

  Fly   919 LKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSEQVGGN---FEAHSDNE 980
            |||.||:|.|:||.|:.:|:::....|...:....:..:::|::| |.:|..|:   :|||||.:
Zfish   905 LKGAFKSVTASIKELKSEELEEFQKTGCIVVDGHDLREEDLRLMY-TFDQSSGSASQYEAHSDAQ 968

  Fly   981 VLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLA 1045
            ||||||:||::.:|:||:|||||||:|||:||..|:|:|.:.:|:......:...:|:||
Zfish   969 VLVLLDVTPDQAMLDEGVAREVINRIQKLRKKGHLVPSDEITVFYRCQPAGEYLHQVIEA----- 1028

  Fly  1046 KVLSNYASIIKTAIKSEFAPYS-SEQASKKRLIASELVDLKGVPLKLTICSTEELQLPNLPWLNI 1109
                 :...|....|:....|. ...||   :|..|...|||..|:|||..
Zfish  1029 -----HTDFILATTKAPLRAYPVCPNAS---VIVQENTQLKGSDLELTIVR-------------- 1071

  Fly  1110 SLAEDLVPRFGNSSKASLFLQHNVSKE--------IISLP--TLRSELEHL-------FGLYGVN 1157
            ..:...|.|...|..|..|:...||.:        ::..|  ..|.:||.|       |||.|..
Zfish  1072 GSSSSSVCRAPVSGSACAFVNLRVSLKDKQQDGVVLLENPKGDNRLDLEQLKRICCSVFGLNGAP 1136

  Fly  1158 FNIYVVDHQKRTTALKSIDE--NLSGKLLVLTR---SQDAPKLSAGYELSPAPYSKFINQHSGK- 1216
            .:|:     ...|||.|..:  :|||:.|.::.   |..|...|:...|.|....:.:|....:
Zfish  1137 VSIF-----NGKTALSSSTDLLSLSGRTLTVSSAAGSSPADVSSSESLLCPYVNLQLVNASPAEC 1196

  Fly  1217 ------SIFTENPLGRAL 1228
                  ::...||.|:.|
Zfish  1197 RTGDVATLLLMNPEGKNL 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	644/1088 (59%)
		IleRS_core	47..>189	CDD:173909	115/141 (82%)
		IleRS_core	<373..650	CDD:173909	199/276 (72%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	105/200 (53%)
iars1	NP_956190.2	PLN02882	11..1070	CDD:215477	640/1082 (59%)
		IleRS_core	39..640	CDD:173909	412/602 (68%)
		Anticodon_Ia_Ile_ABEc	640..833	CDD:153415	105/200 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594402
Domainoid	1	1.000	915	1.000	Domainoid score	I46
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1339	1.000	Inparanoid score	I136
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto39426
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1443
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840