DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS and Iars1

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_001094042.1	Gene:	Iars1 / 306804	RGDID:	621022	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1240	Identity:	674/1240 - (54%)
Similarity:	888/1240 - (71%)	Gaps:	62/1240 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VCRVPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKD 74
            |.:|||||:||||||.:||.|...|.|::|.:.||.:||:|||||||||||||||||||||||||
  Rat     2 VQQVPENISFPAEEEKILQFWSKYNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKD 66

  Fly    75 IVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEW 139
            ||||||:|.|:||||||||||||||||:||||.|.|||||||||||||.||.:||.|||||:.||
  Rat    67 IVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEW 131

  Fly   140 ENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQ 204
            ::.|||:||||||.||||||||.:|||:||:||||:||||||:||||||:||||.|.|||||:||
  Rat   132 KSTVTRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGTPLSNFESNQ 196

  Fly   205 NYKEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAES 269
            |||:|.||.|.|........||..:.|||||||||||.|.||:|.:.|||::||...:||:|.|:
  Rat   197 NYKDVQDPSVFVTFPLEEDENTSLVAWTTTPWTLPSNLALCVNPEIQYVKIKDVSRGKLFILMEA 261

  Fly   270 RLSYVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNA 334
            |||.:||.|::||:.|:|.|.:||...|||||.||.| ..|..|:.||||.||.::.|||:||.|
  Rat   262 RLSALYKQESDYEILERFPGASLKGKKYKPLFDYFIK-CKENGAFTVLVDHYVKDEEGTGVVHQA 325

  Fly   335 PYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSS 399
            ||||.||:|||:...:|.|.|..:||||.:|.||.|.:.|.||||||:||.|:..||.:|.|:.:
  Rat   326 PYFGADDHRVCMDFNIIQKDSAPVCPVDASGCFTEEVTHFVGQYVKDADKNIIRMLKEQGRLLVA 390

  Fly   400 GQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDW 464
            ....||||||||||||||||:|||||||||||...||..:...||||:||:||||||||||||||
  Rat   391 STFTHSYPFCWRSDTPLIYKSVPSWFVRVEHMVDQLLKNNDLCYWVPEFVREKRFGNWLKEARDW 455

  Fly   465 AISRNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRR 529
            |||||||||||||:|.|...:|.|.|||:.:|.||||.::.|||||||||:.|||.. |..||||
  Rat   456 AISRNRYWGTPIPLWVSEDFEEVVCIGSVAELEELSGTKISDLHRESIDHLTIPSRC-GKGPLRR 519

  Fly   530 IAPVFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPF 594
            ::.||||||||||||:||.|:|||::::|.:.||||||||||||||||||||||::||||.:.||
  Rat   520 VSEVFDCWFESGSMPYAQVHYPFESKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPF 584

  Fly   595 KNLIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDII 659
            ||:|.:||:||:|||||||||||||||:.:::||||||||||||||||||||:||||||||||::
  Rat   585 KNVIVNGLILASDGQKMSKRKKNYPDPVSIINKYGADALRLYLINSPVVRAENLRFKEEGVRDVL 649

  Fly   660 KDVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFA 724
            |||.|||||||||.:||:.|..||:   ..::.|: |..::  :..::.|.|||||.:||:.||.
  Rat   650 KDVLLPWYNAYRFFIQNVFRLHKEE---EVEFLYN-EHTVR--ESPNITDRWILSFMQSLIAFFE 708

  Fly   725 TEMKMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFT 789
            |||..||||||||||.||:|.|||||||:||||:|||.|.:.|:.:|:||:.||.::.::|||:|
  Rat   709 TEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYT 773

  Fly   790 PYLTEYIFQRLVLFQPAGTLEHAD--SVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDR 852
            |:|||.::|.|.|.....::...|  |:||.|:|..:::.|....|.:|:.||||:|||||:|||
  Rat   774 PFLTELMYQNLKLLIDPASIRDKDTLSIHYLMLPHVREELIDKKTENAVSRMQSVIELGRVIRDR 838

  Fly   853 RTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQ 917
            :|:|:|||:.||:.||:|.:.||.||:|:.:|:.||||||:|||:||.|||:.|||||||..||:
  Rat   839 KTIPIKYPLKEIVVIHQDPEALEDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGK 903

  Fly   918 RLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSEQVGG--NFEAHSDNE 980
            ||||.|||||.|:|.|.::|:::....|...:....:..:::|::|...:..||  .||||||.:
  Rat   904 RLKGAFKAVMVAVKQLSNEELEQFQKSGSIVVEGHELHEEDIRLMYTFDQATGGTAQFEAHSDAQ 968

  Fly   981 VLVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLA 1045
            .|||||:||::.:::||:|||||||:|||:||..|:|||.:.:::...::.:          .|:
  Rat   969 ALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYNAKSEGR----------YLS 1023

  Fly  1046 KVLSNYASIIKTAIKSEFAPYSSEQASKKRLIASELVDLKGVPLKLTICSTEELQLPNLPWLNIS 1110
            .|:.::...|...||:...||  ...:...::..|...|||..|::||.....:..|...::|::
  Rat  1024 NVIESHTDFIYATIKAPLKPY--PVPTSDNILIQEQTQLKGYELEITITRGSCVPGPACAYVNLN 1086

  Fly  1111 LAEDLVPRFGNSSKASLFLQHNVSKEIISLPTLRSELEHLFGLYGVNFNIY--VVDHQKRTTALK 1173
            :..:     |......|.|::......::|..|:|.:..:||:.....:::  ..:.|.:|..|
  Rat  1087 ICAN-----GTEQGGVLLLENPKGDNQLNLEKLKSVITSIFGVKSTGLSVFNGGTELQNQTDLL- 1145

  Fly  1174 SIDENLSGKLLVLTRSQDAPKLSAGYELSPAP-----YSKFINQH----------SGK--SIFTE 1221
                :|||:.|.:|         ||..|:||.     ..::||..          :|.  ::..|
  Rat  1146 ----SLSGRTLCVT---------AGASLAPASSPSTLLCQYINLQLVNAEPQECLTGTVGTLLLE 1197

  Fly  1222 NPLGR 1226
            ||||:
  Rat  1198 NPLGQ 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	642/1087 (59%)
		IleRS_core	47..>189	CDD:173909	117/141 (83%)
		IleRS_core	<373..650	CDD:173909	195/276 (71%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	100/198 (51%)
Iars1	NP_001094042.1	PLN02882	6..1070	CDD:215477	640/1083 (59%)
		IleRS_core	39..>181	CDD:173909	117/141 (83%)
		IleRS_core	<406..640	CDD:173909	170/234 (73%)
		Anticodon_Ia_Ile_ABEc	640..833	CDD:153415	100/198 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352469
Domainoid	1	1.000	905	1.000	Domainoid score	I45
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1365	1.000	Inparanoid score	I117
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto97146
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810