Protein Alignment IleRS and iars-1

DIOPT Version :9

• Sequence 1: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Sequence 2: NP_001366774.1
• Gene: iars-1 / 177926
• WormBaseID: WBGene00002152
• Length: 1141
• Species: Caenorhabditis elegans
• Alignment Length: 1198
• Identity: 631/1198 - (52%)
• Similarity: 815/1198 - (68%)
• Gaps: 85/1198 - (7%)

  Fly    13 VPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVT 77
            ||:||||..||:.|.|||:.||.|::..:|||.:|.:|||||||||||||||||:|..||||:|.
 Worm     7 VPDNINFAREEDKVAQKWQDENTFQRSVELSKDRPHFTFYDGPPFATGLPHYGHMLTSTIKDVVG 71

  Fly    78 RYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWENV 142
            |:|:|.|::|:||||||.||||||:||||.|.|.||:||.|||||.||.|||||||||:.|||..
 Worm    72 RWAHQNGHYVERRFGWDTHGLPVEYEIDKTLGISGPQDVMKMGIANYNNECRKIVMRYSGEWEKT 136

  Fly   143 VTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYK 207
            :.|:|||:|||:||||||||:|||:||.|.:|..|||||:||||||:||||:|.||||||.||||
 Worm   137 MGRLGRWVDFKHDYKTLYPWFMESVWWAFSELHKKGLVYKGVKVMPFSTACSTPLSNFEAGQNYK 201

  Fly   208 EVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRLS 272
            :||||.|.|..:.:..||...:.|||||||||||.|..|||.|.||..:|..:...:|:.|.||.
 Worm   202 DVVDPAVFVGFKLLDCPNRQLVAWTTTPWTLPSNLALVVHPDMLYVVTKDKTTGIEYVVLEERLG 266

  Fly   273 YVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYF 337
            .:  .....||.||..|..||||.|:|||||||....|..|:|||.|.:||.|||||:||.||||
 Worm   267 EL--KNDNLEVIEKLAGSQLKDLRYEPLFPYFAYMREERNAFRVLNDTFVTSDSGTGVVHQAPYF 329

  Fly   338 GEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQV 402
            ||.|::||:|.|:|.|..:::|||||:|::|:|..|::|.||||:||.|:..||..||||...:|
 Worm   330 GEIDFQVCVANGVIAKDQKMICPVDESGKYTSEVPDYQGVYVKDADKLIIKRLKEMGNLVRQAEV 394

  Fly   403 KHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAIS 467
            ||||||||||||||:||||||||:.||.:...||..:.:|||||.|||||||.|||::|||||:|
 Worm   395 KHSYPFCWRSDTPLLYKAVPSWFINVETLIPRLLANNDETYWVPAFVKEKRFANWLRDARDWAVS 459

  Fly   468 RNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRIAP 532
            |||:|||||.:|.|..|:|.|.:|||.:|.||||.::.||||||:|.:.|||. .|...|:|::.
 Worm   460 RNRFWGTPINLWVSEDGEEVVCVGSIAELEELSGQKITDLHRESVDDVTIPSR-SGRGVLKRVSE 523

  Fly   533 VFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNL 597
            ||||||||||||:||.|:||||.|.|.:|||||||||||||||||||||||:|||||||.|||||
 Worm   524 VFDCWFESGSMPYAQNHYPFENRKIFEDNFPADFIAEGIDQTRGWFYTLLVLSTALFNKPPFKNL 588

  Fly   598 IASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDIIKDV 662
            |.:|||||:||.||||.||||||||.:|:||||||||||||||||||.|:|||:||||||::|||
 Worm   589 ICNGLVLASDGAKMSKSKKNYPDPMLIVNKYGADALRLYLINSPVVRGENLRFREEGVRDLLKDV 653

  Fly   663 FLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFATEM 727
            ||||:|||||.:||:..||.|  .||   .:|...|:.:   .:|:|.||.||..||:.|...||
 Worm   654 FLPWFNAYRFFVQNVQAYEHE--TGN---VFDMNVHVAS---ENVMDRWIESFTNSLVAFVRKEM 710

  Fly   728 KMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPYL 792
            ..||||.||..||||.|.|||.|:||||:|:||:.|..:...:|..|..||..:|::||||||:.
 Worm   711 DSYRLYAVVGPLTKFFDTLTNIYIRLNRKRVKGDNGLHEQHHALAALGRVLILIVRLMAPFTPFF 775

  Fly   793 TEYIFQRLVLFQPAGTLEHADSVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRTLPV 857
            .|||:  |.|.:..|:.|  :|||:.|:|...:..|...:||.|.:|::|::|.|::|||..|.|
 Worm   776 CEYIW--LNLKKVIGSTE--ESVHFLMLPKPDESLIDETVERRVEVMRNVIDLVRLVRDREGLAV 836

  Fly   858 KYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQRLKGN 922
            |||:.|:|.|::|||.||.:|:|:.:||.||||||||:|.||:|||:||:|||:.|.||.||||.
 Worm   837 KYPLKEMIVINRDSQFLEDVKSLESYILLELNVRKLTVSQDKQKYGITLKAEPNFKILGARLKGE 901

  Fly   923 FKAVMAAIK-ALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSEQVGGNFEAHSDNEVLVLLD 986
            .|.|...:| .:.:.|::|.:.:|...:|...:..:||.:.|......|..::.|||.:.:|::|
 Worm   902 QKKVADYLKNQITESELEKFLLEGKLTVLGHELSSEEVAVSYAAGSDQGHGYKTHSDAKTIVMID 966

  Fly   987 MTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLAKV---- 1047
            .|.:|.|:||||.|||.||||:|:|:|:|:.||...: |.:         |..|.:|||||
 Worm   967 TTEDESLIEEGLCREVTNRVQRLRKQAKLVSTDTAHV-HIV---------VSPADSQLAKVVAAK 1021

  Fly  1048 LSNYASIIKTAIKSEFAPYSSE--QASKKRLIASELVDLKGVPLKLTICSTEELQLPNLPWLNIS 1110
            |::..|...|.||....|.:::  .|:.|..|....|:|                     ||
 Worm  1022 LNDIVSATGTPIKLGSPPAAAKAPTATSKSAIKDSEVEL---------------------WL--- 1062

  Fly  1111 LAE----DLVPRFGNSSKASLFLQHNVSKEIISLPTLRSELEHLFGLYGVNFNI-YVVDHQKRTT 1170
            .||    |.:.....|.|..:.              :::|.|||.|...:.::: ..:|......
 Worm  1063 FAEGDSFDGITVVDGSKKVRVH--------------VKTEKEHLKGYADLLYHVRSALDLWNGKI 1113

  Fly  1171 ALKSID----------ENLSGKLLVLTR 1188
            |||::|          .:|.|:.|.|.|
 Worm  1114 ALKNVDGSAVHPTVDVTSLVGQTLQLVR 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	609/1087 (56%)
		IleRS_core	47..>189	CDD:173909	102/141 (72%)
		IleRS_core	<373..650	CDD:173909	194/276 (70%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	92/196 (47%)
iars-1	NP_001366774.1	PLN02882	8..1033	CDD:215477	600/1049 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166118
Domainoid	1	1.000	860	1.000	Domainoid score	I18
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1222	1.000	Inparanoid score	I89
Isobase	1	0.950	-	0	Normalized mean entropy	S440
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto18421
orthoMCL	1	0.900	-	-		OOG6_100811
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1443
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790