DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IleRS and iars2

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_001120515.1	Gene:	iars2 / 100145647	XenbaseID:	XB-GENE-987849	Length:	992	Species:	Xenopus tropicalis

Alignment Length:	983	Identity:	275/983 - (27%)
Similarity:	422/983 - (42%)	Gaps:	191/983 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EEENVLQ--KWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQG 84
            ||...||  .|:.|.         |.|.:::.:||||:|.|.||.||.|...:|||..|:...:|
Frog    65 EESGFLQLYAWQRER---------KTKKEFSLHDGPPYANGDPHVGHALNKILKDITNRFHMMRG 120

  Fly    85 YHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYN---AECRKIVMRYA----DEWENV 142
            |.|....||||||||:|.:.           :|::|..|.|   .|.|:....:|    ::.::.
Frog   121 YKVSYVPGWDCHGLPIELKA-----------LAELGEEAENMSPTEIRRKAKMFAEKAIEKQKSS 174

  Fly   143 VTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYK 207
            ..|.|...|:...|.|..|.|......||.:::|||.:||..|.:.:|.:..|:|:..|...|.:
Frog   175 FIRWGIMADWDKCYYTFDPKYEAKQLDIFYKMYDKGHIYQDYKPVFWSPSTRTALAEAELEYNQE 239

  Fly   208 EV------------VDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKS 260
            .:            ..|.:...::..|..:|  |||||.|||:|:|.|.|..|...|...:...:
Frog   240 HISRSIFAKFPMHKAPPKLASIIDGSSAVST--LVWTTQPWTIPANQAICYMPDTEYAIAKCANT 302

  Fly   261 DRLFVLAESRL-SYVYKSETEYEVKEKFVGKTLKD---LHYKPLFPYFAKRGAEVKAYRVLVDEY 321
            ...::||..|: |......|:.:|...|.|..|:.   ||     |..|.|.:.     :|...:
Frog   303 GEQYILATDRIESTALSLGTQLQVISTFKGLDLEGGICLH-----PTIADRLSP-----LLPANH 357

  Fly   322 VTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEA-SDFEGQYV-KDSDK 384
            ||...|||:||.||..|.:||.|.....|     .|.|.|||:|.||..| ::.|.:.| .|.::
Frog   358 VTMAKGTGLVHTAPAHGIEDYSVASHHKL-----PVDCLVDESGHFTTGAGAELENKAVLTDGNE 417

  Fly   385 QIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFV 449
            .::..|.|..:|:......||||:.||:..|:|.:|...|||...::.....|...:..:||...
Frog   418 TVIQMLHASKSLLKEESFVHSYPYDWRTKKPVIIRASKQWFVNTANIKDKAQDVLKKVKFVPASA 482

  Fly   450 KEKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVV----IGSIKQLAELSGVQV------ 504
             ..|....|.....|.|||.|.||.|||::......:.::    :|.|..|.|..|..|
Frog   483 -AARMLEMLDRRTYWCISRQRGWGVPIPVFYHKETGKPLINRHSVGHIMSLVEQHGTDVWWTLPL 546

  Fly   505 EDLHRESIDHIEIPSAVPGNPPLRRI------------APVFDCWFESGSMPFAQQHFPFENEKD 557
            |:|         :|.||     |:::            ..|.|.||:||:   :..|...:.|:
Frog   547 EEL---------LPKAV-----LQKVEGSSDACDYEQGRDVLDIWFDSGT---SWAHVLEDGEQ- 593

  Fly   558 FMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPM 622
                 .||...||.||..|||.:.|:.|.|..||||::|:|..|..|:..|:||||...|..||.
Frog   594 -----RADVYMEGKDQLGGWFQSSLLTSVAARNKAPYRNIIVHGFTLSEKGEKMSKSVGNVVDPD 653

  Fly   623 EVVH---------KYGADALRLYLINSPVVRAESLRFKE--------EGVRDIIKDVFLPWYNAY 670
            .|::         .||||.||.::       |||..|.|        ...||.|..:    .|..
Frog   654 VVINGGQDKVNEPAYGADVLRWWV-------AESNVFTEVLIGPAVLNSARDDINKL----RNTL 707

  Fly   671 RFLLQNIVRY--EKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFATEMKMYRLY 733
            ||:|.|:..:  |::.:.....|               |||.::|...:..........|.|...
Frog   708 RFMLGNLSDFTPERDSVPSTEMY---------------VIDQYMLHILQDYGSKVTDAYKGYEFG 757

  Fly   734 TVVPRLTKFIDQ-LTNWYVRLNRRRIKGELGADQCIQSLDT-LYDVLYTMVKMMAPFTPYLTEYI 796
            .||..|...:.: |:::|..:.:.|:..:...|...:|..| |.:.|..:|:..||..|:|.|.:
Frog   758 KVVRLLEALVTRDLSSFYFSIIKDRLYCDEEKDPKRRSCQTVLAEALDVVVRSFAPILPHLAEEV 822

  Fly   797 FQRLVLFQPAGTLEHADSVHYQMMPVSQKKFIR-NDIERSVALMQSVVELGRVMRDR--RTLPVK 858
            ||.|..      .:.:||..       :..:|: |.:.:.:.|::: :|....:||.  .::|.|
Frog   823 FQYLPY------RKESDSAF-------RTGWIKPNTVWKKLGLVEA-IEAACSIRDAFLGSIPGK 873

  Fly   859 YPVSEIIAIHKDSQIL-EAIKTLQD---FILSELN----VRKLTLSSDKEKYGVTLRAEPDHKAL 915
            ......:.|..|..:| |.::|||:   ...|:||    ..:.:|.||     :.|...|:...
Frog   874 NAAEYEVTIVIDPGLLFELMETLQEEPSSCTSQLNELLMCSQTSLLSD-----LPLDLPPEASV- 932

  Fly   916 GQRLKGNF 923
               |||:|
Frog   933 ---LKGSF 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	275/983 (28%)
		IleRS_core	47..>189	CDD:173909	49/148 (33%)
		IleRS_core	<373..650	CDD:173909	91/308 (30%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	44/209 (21%)
iars2	NP_001120515.1	ileS	35..988	CDD:235588	275/983 (28%)
		nt_trans	83..>221	CDD:294020	49/148 (33%)
		tRNA-synt_1_2	<331..>388	CDD:290334	22/71 (31%)
		nt_trans	<448..685	CDD:294020	80/267 (30%)
		Anticodon_Ia_Ile_BEm	688..867	CDD:153414	44/211 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930