Protein Alignment IleRS and iars1

DIOPT Version :9

• Sequence 1: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Sequence 2: NP_001090690.1
• Gene: iars1 / 100036668
• XenbaseID: XB-GENE-1001585
• Length: 1259
• Species: Xenopus tropicalis
• Alignment Length: 1236
• Identity: 670/1236 - (54%)
• Similarity: 888/1236 - (71%)
• Gaps: 61/1236 - (4%)

  Fly    12 RVPENINFPAEEENVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFATGLPHYGHILAGTIKDIV 76
            :|||:||||.|||.:|:.|:..:.|::|.:.||.:|:||||||||||||||||||||||||||||
 Frog     4 QVPESINFPTEEEKILELWKSLDCFQECLKQSKNRPRYTFYDGPPFATGLPHYGHILAGTIKDIV 68

  Fly    77 TRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAAYNAECRKIVMRYADEWEN 141
            ||:|:|.|:||:|||||||||||||:||||.|.|||||||||||||.||.:||.|||||:.|||.
 Frog    69 TRFAHQSGFHVERRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRGIVMRYSQEWEI 133

  Fly   142 VVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNY 206
            .|||:||||||||||||||||:||::||:||||:||||||:||||||:||||.|.|||||::|||
 Frog   134 SVTRLGRWIDFKNDYKTLYPWFMETVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNY 198

  Fly   207 KEVVDPCVVVALEAVSLPNTFFLVWTTTPWTLPSNFACCVHPTMTYVKVRDVKSDRLFVLAESRL 271
            |:|.||.|:|....:.......:.|||||||||||.|.||:|.:.|||::|..:..:::|.|:||
 Frog   199 KDVQDPSVIVTFPLLDDSGVSLVAWTTTPWTLPSNLALCVNPELIYVKLKDKSNGNVYILMEARL 263

  Fly   272 SYVYKSETEYEVKEKFVGKTLKDLHYKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPY 336
            |.:||:|.||::.|:|.|..||...||||||||.| .:|..|:.|:.|.||..:.|||:||.|||
 Frog   264 SALYKAENEYDILERFPGNNLKGKKYKPLFPYFEK-ASERGAFTVVTDNYVKSEEGTGVVHQAPY 327

  Fly   337 FGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKARGNLVSSGQ 401
            ||.||||||:...:|.|.|..:||||.:|.||.|.:||.||||||:||.|:..||..|.||.|..
 Frog   328 FGADDYRVCMDFNIIQKDSVPVCPVDASGCFTKEVTDFAGQYVKDADKNIIKLLKEHGRLVHSSS 392

  Fly   402 VKHSYPFCWRSDTPLIYKAVPSWFVRVEHMSKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAI 466
            .||:||||||||||||||||||||||||||...||..:||.||||:||:|||||||||:||||||
 Frog   393 YKHNYPFCWRSDTPLIYKAVPSWFVRVEHMVDKLLQNNSQCYWVPEFVREKRFGNWLKDARDWAI 457

  Fly   467 SRNRYWGTPIPIWRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRIA 531
            |||||||||||:|.|...:|.|.:||:.:|.||:|.:|.||||||:||:.|||. .|...|||:.
 Frog   458 SRNRYWGTPIPLWVSEDFEEVVCVGSLAELEELTGTKVTDLHRESVDHLTIPSR-RGKGSLRRVT 521

  Fly   532 PVFDCWFESGSMPFAQQHFPFENEKDFMNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKN 596
            .||||||||||||:||.|:||||.::|.:.||||||||||||||||||||||:|||||.:.||||
 Frog   522 EVFDCWFESGSMPYAQVHYPFENRREFEDCFPADFIAEGIDQTRGWFYTLLVLSTALFGQPPFKN 586

  Fly   597 LIASGLVLAADGQKMSKRKKNYPDPMEVVHKYGADALRLYLINSPVVRAESLRFKEEGVRDIIKD 661
            :|.:|||||:|||||||.||||||||:|::.||:||||||||||||||||:|||||:||||::||
 Frog   587 VIVNGLVLASDGQKMSKSKKNYPDPMQVINSYGSDALRLYLINSPVVRAENLRFKEDGVRDVLKD 651

  Fly   662 VFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLEFFATE 726
            ||||||||||||:|||.|..||:   |..:.::..   ......:::|.||:||.:||::||..|
 Frog   652 VFLPWYNAYRFLMQNIYRLHKEE---NIHFLFNES---TKQQSNNIMDQWIISFTQSLVQFFKAE 710

  Fly   727 MKMYRLYTVVPRLTKFIDQLTNWYVRLNRRRIKGELGADQCIQSLDTLYDVLYTMVKMMAPFTPY 791
            |..||||||||||.||:|.|||||||:||||:|||.|.:.|..:|:||:.||::|.::||||||:
 Frog   711 MSAYRLYTVVPRLVKFVDMLTNWYVRMNRRRLKGESGTEDCQMALETLFSVLFSMCRLMAPFTPF 775

  Fly   792 LTEYIFQRLVLFQPAGTLEHAD--SVHYQMMPVSQKKFIRNDIERSVALMQSVVELGRVMRDRRT 854
            :||.::|:|.|.....:::..|  |:||.|:|.:::..|...||.:|:.||||:|||||:|||:|
 Frog   776 ITEMMYQKLRLLIDPSSMQDKDTKSIHYLMLPTAREDLIDKKIESAVSRMQSVIELGRVIRDRKT 840

  Fly   855 LPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKYGVTLRAEPDHKALGQRL 919
            ||||||:.|:|.||:||:.|..||:|:.:|..||||:::|:|::|:|||:.|||||||..||:||
 Frog   841 LPVKYPLKEVIVIHQDSEALADIKSLEKYIKEELNVKQVTVSTNKDKYGIRLRAEPDHMVLGKRL 905

  Fly   920 KGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSEQVGG---NFEAHSDNEV 981
            ||.||.||||||.|:.:::::....|...:....:..:::|::| |.:||.|   :||||||.:|
 Frog   906 KGAFKTVMAAIKELKSNQLEEFQKTGSIVVDGHELHEEDIRLLY-TFDQVSGEDAHFEAHSDAQV 969

  Fly   982 LVLLDMTPNEELLEEGLAREVINRVQKLKKKAQLIPTDPVLIFHELAADNKAKQEVLEAQAQLAK 1046
            |||||:||::.:::||:|||||||:|||:||..|:|||.:.|:::...:....|.|:|
 Frog   970 LVLLDVTPDQSMVDEGVAREVINRIQKLRKKGNLVPTDEITIYYQSLPEGNYLQSVIE------- 1027

  Fly  1047 VLSNYASIIKTAIKSEFAPYSSEQASKKRLIASELVDLKGVPLKLTICSTEELQL-----PNLPW 1106
               .:...|...:||...||....:|  .::..|...|||..|::|:.......:     |...:
 Frog  1028 ---RHTDFILATVKSPLKPYPVPPSS--NVVIKEKTQLKGSDLEITLVRGSPQPVAGDSGPACAY 1087

  Fly  1107 LNISLAEDLVPRFGNSSKASLFLQHNVSKEIISLPTLRSELEHLFGLYGVNFNIYVVDHQKRTTA 1171
            :|:.::.:     |......|.|::.....:..|..|::.:.::|.| ....::|.     ..|.
 Frog  1088 VNLRISVN-----GTEQNGCLLLENPKGDALSKLAELKAAVCNIFHL-SPQLSMYC-----DRTE 1141

  Fly  1172 LKSIDEN---LSGKLLVLTRSQDAPKLSAGYELSP------APY--SKFINQHSGKSIFTENPLG 1225
            |:: |.|   ||||.|.::.:..|       |:||      ..|  .:.:|:....::..|||:|
 Frog  1142 LRN-DCNLLSLSGKTLHVSSASPA-------EVSPDGSQLLCQYINLRLLNEERQGTLLLENPIG 1198

  Fly  1226 R 1226
            :
 Frog  1199 Q 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	641/1086 (59%)
		IleRS_core	47..>189	CDD:173909	117/141 (83%)
		IleRS_core	<373..650	CDD:173909	199/276 (72%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	101/198 (51%)
iars1	NP_001090690.1	PLN02882	6..1077	CDD:215477	640/1091 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	907	1.000	Domainoid score	I52
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5325
Inparanoid	1	1.050	1360	1.000	Inparanoid score	I136
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0004669
OrthoInspector	1	1.000	-	-		oto103839
Panther	1	1.100	-	-	LDO	PTHR42780
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3282
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160