DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IleRS and iars2

DIOPT Version :9

Sequence 1:	NP_524840.2	Gene:	IleRS / 45785	FlyBaseID:	FBgn0027086	Length:	1229	Species:	Drosophila melanogaster
Sequence 2:	NP_001157270.1	Gene:	iars2 / 100001219	ZFINID:	ZDB-GENE-030616-608	Length:	983	Species:	Danio rerio

Alignment Length:	926	Identity:	253/926 - (27%)
Similarity:	386/926 - (41%)	Gaps:	194/926 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LERNDVCRVPENINFPA--EEE---------NVLQKWRHENIFEKCSQLSKGKPKYTFYDGPPFA 58
            |.|.|   .|..:|.|:  |:|         :.|.||:.|         .|.|.:|..:||||:|
Zfish    37 LPRTD---FPIKVNGPSLLEQEIKIQQKCGFDQLYKWQRE---------KKAKKEYCLHDGPPYA 89

  Fly    59 TGLPHYGHILAGTIKDIVTRYAYQQGYHVDRRFGWDCHGLPVEFEIDKLLNIKGPEDVAKMGIAA 123
            .|.||.||.|...:|||..|:...:|..|....||||||||:|.   |.|...|..::..:.|
Zfish    90 NGDPHVGHALNKILKDIRNRFEVLRGRQVHYVPGWDCHGLPIEL---KALGDLGTNELTPVQI-- 149

  Fly   124 YNAECRKIVMRYADEWENVVTRVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMP 188
             ..:.|:...:..........|.|...|:.|.|.|....|..:...:|:::.:|||:||..|.:.
Zfish   150 -RQKAREFAEKAISRQRAAFQRWGVMADWDNCYYTFDGKYEAAQLKVFQEMHNKGLIYQDYKPVF 213

  Fly   189 YSTACTTSLSNFEANQNYKEVVDPCVVVALEAVSLP-----------NTFFLVWTTTPWTLPSNF 242
            :|.:..|:|:..|...| .|.|...:.:....::||           |...|:|||.|||:|:|.
Zfish   214 WSPSSRTALAEAELEYN-PEHVSRSLYITFPLLTLPAKLTAKAEGLSNVSALIWTTQPWTIPANQ 277

  Fly   243 ACCVHPTMTYVKVRDVKSDRLFVLAESR---LSYVYKSETEYEVKEKFVGKTLK-DLHYKPLFPY 303
            |.|..|.:.|..|:...:::|.::|..|   ||.:.|:..|..|  .|.|..|: .:...|..|
Zfish   278 AVCYMPKVQYSVVKRADTEQLLLVATERINSLSSLLKTNLESLV--TFAGTDLEGGVCQHPTIP- 339

  Fly   304 FAKRGAEVKAYRVLVDEYVTEDSGTGIVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFT 368
                   .|...:|...:||...|||:||.||..|.|||.|.....|     .|.|.|||.||||
Zfish   340 -------SKEVPLLPASHVTMTKGTGLVHTAPAHGMDDYSVATHFNL-----PVECMVDEEGRFT 392

  Fly   369 NEA-SDFEGQYVKD-SDKQIMAALKARGNLVSSGQVKHSYPFCWRSDTPLIYKAVPSWFVRVEHM 431
            ..| ::.:.:.|.| .:..:::.|:|.|.:|......||||:.||:..|::.:|...||:....:
Zfish   393 ELAGAELQNKSVMDEGNAAVISVLQAAGAVVKEEDCVHSYPYDWRTKQPVVIRASRQWFINTATL 457

  Fly   432 SKNLLDCSSQTYWVPDFVKEKRFGNWLKEARDWAISRNRYWGTPIPI------------------ 478
            .....|...:...:|:..:.... :.|.....|.|||.|.||.|||:
Zfish   458 KDKAKDALQKVRVIPESARSSLL-SMLDRRTYWCISRQRSWGVPIPVFYHKETGEPLLNKHTVTH 521

  Fly   479 -------------WRSPSGDETVVIGSIKQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRI 530
                         |..|.  ||.:...:.|.::.|.|.         |::             |.
Zfish   522 IAKVFSEKGSDSWWTEPV--ETFLTPDVLQKSKASSVS---------DYV-------------RG 562

  Fly   531 APVFDCWFESGS-----MPFAQQHFPFENEKDFMNNFP-ADFIAEGIDQTRGWFYTLLVISTALF 589
            ..|.|.||:||:     :|          |.|     | ||...||.||..|||.:.|:.|.|:.
Zfish   563 EDVLDIWFDSGASWAAVLP----------ESD-----PRADSYVEGKDQIGGWFQSSLLTSVAVR 612

  Fly   590 NKAPFKNLIASGLVLAADGQKMSKRKKNYPDPMEVVH---------KYGADALRLYLINSPVVRA 645
            ||||:|.|:..|..::..|:||||...|..||..|::         .||||.||.::       |
Zfish   613 NKAPYKALVVHGFAVSEKGEKMSKSIGNVVDPDVVINGGKDSSVSPPYGADVLRWWV-------A 670

  Fly   646 ESLRFKE----EGVRDIIKDVFLPWYNAYRFLLQNIVRYEKEDLAGNGQYTYDRERHLKNMDKAS 706
            ||..|.|    ....:..||......|..:|||.|:..::.     ..|....::.|
Zfish   671 ESNVFSEVQIGPNALNAAKDSINKLRNTLKFLLGNLQGFDP-----RSQAVDPKQMH-------- 722

  Fly   707 VIDVWILSFKESLLEFFATEMKMYRLYT------VVPRLTKF-IDQLTNWYVRLNRRRI----KG 760
            .||.::|..   |.||   .||:...|:      |:..|..| ..:|:|:|..:.:.|:    :.
Zfish   723 YIDQYMLHL---LREF---SMKVTDAYSEFNYGLVIRLLQSFTARELSNFYFSIIKDRLYCDPED 781

  Fly   761 ELGADQCIQSLDTLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADSVHYQMMPVSQK 825
            .:|...|...|:   ::|..:.:.:||..|:|.|.::..........||..:..::  ..||.:|
Zfish   782 SVGRRSCQTVLE---EILDGVSRSIAPVLPHLAEEVYLHAPGHDEGNTLFRSGWIN--TSPVWRK 841

  Fly   826 KFIRNDIERSVALMQS 841
            ..:...:|.:.|:..|
Zfish   842 PGLEEAVEGACAIRDS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	251/922 (27%)
		IleRS_core	47..>189	CDD:173909	46/141 (33%)
		IleRS_core	<373..650	CDD:173909	85/323 (26%)
		Anticodon_Ia_Ile_ABEc	650..847	CDD:153415	44/207 (21%)
iars2	NP_001157270.1	ileS	31..976	CDD:235588	253/926 (27%)
		nt_trans	78..>214	CDD:294020	46/141 (33%)
		tRNA-synt_1_2	<330..>382	CDD:290334	19/64 (30%)
		IleRS_core	<441..677	CDD:173909	74/282 (26%)
		Anticodon_Ia_Ile_BEm	680..859	CDD:153414	42/202 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830