DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ThrRS and MST1

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_012727.1	Gene:	MST1 / 853640	SGDID:	S000001677	Length:	462	Species:	Saccharomyces cerevisiae

Alignment Length:	427	Identity:	192/427 - (44%)
Similarity:	273/427 - (63%)	Gaps:	38/427 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 IGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYR-KRGFQEVISPNIYNAKLWMTSGHW 415
            :.:.|:||....|||||.||.|.||.|:|.|:.|:|.:.: |.||.||::|.||...||..||||
Yeast    42 VSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHW 106

  Fly   416 QHYAENMFSFEA---EKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGALTG 477
            ::||::||..|.   |||::.|||||||||||||..::||:.|||||.:||..|||||.||||:|
Yeast   107 ENYADDMFKVETTDEEKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASGALSG 171

  Fly   478 LTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYT-IFGF---------SFQLVLSTRPDNYL 532
            |||:|:|.|||.||||.|.|:|||:...|:.:..||. ||.|         ::.:..|||||:::
Yeast   172 LTRLRKFHQDDGHIFCTPSQVKSEIFNSLKLIDIVYNKIFPFVKGGSGAESNYFINFSTRPDHFI 236

  Fly   533 GELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRF 597
            |:|:.||.||:.|.|.|.|.|.|||.|||||||||||:||.:.|.|::.||.||||||||||.||
Yeast   237 GDLKVWNHAEQVLKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTHQVATIQLDFQLPERF 301

  Fly   598 NLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQ----- 657
            :|.:...|...|||::||||..||:||.:|:|.::..|:|||||:|.|.:::||.....|
Yeast   302 DLKFKDQDNSYKRPIMIHRATFGSIERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMC 366

  Fly   658 --YAQSVRDQ----------LHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNT 710
              ..:.:|::          |:|..|..:.|. ..:.:..:|::|.|..::::::|||:|.....
Yeast   367 TALQKKLRNELEADDMEPVPLNDWHFNVDLDI-RNEPVGYRIKSAILKNYSYLIIVGDEEVQLQK 430

  Fly   711 VNVRTRDNKVHGEVSVAELITKLQKIRDEFIANEDSF 747
            .|:|.|||:     ...|.:| :.:|.::||..|.::
Yeast   431 YNIRERDNR-----KSFEKLT-MSQIWEKFIELEKNY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	189/418 (45%)
		TGS_ThrRS_N	109..170	CDD:133437
		tRNA_SAD	276..323	CDD:197931
		ThrRS_core	347..643	CDD:238394	164/304 (54%)
		ThrRS_anticodon	643..734	CDD:238437	24/107 (22%)
MST1	NP_012727.1	ThrRS_core	44..347	CDD:238394	164/302 (54%)
MST1	NP_012727.1	ThrRS_anticodon	347..459	CDD:238437	27/118 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S259
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860