DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ThrRS and TARS2

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_079426.2	Gene:	TARS2 / 80222	HGNCID:	30740	Length:	718	Species:	Homo sapiens

Alignment Length:	691	Identity:	352/691 - (50%)
Similarity:	476/691 - (68%)	Gaps:	21/691 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LSPLPKYIEER-NVFWEKCKAEYE--AELAAKKREPIKVTLPDGKQVDATSWETTPYEVARGISQ 137
            :|..|:::.|| .:|.|...|:.:  |.:|.|:...||::||.|:::||.:|.||||::||.||.
Human    25 VSTPPRWLAERLGLFEELWAAQVKRLASMAQKEPRTIKISLPGGQKIDAVAWNTTPYQLARQISS 89

  Fly   138 GLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYG 202
            .|||..|.::||||.:||:|.||.:..|:.|.||.||.:|||||||.|::|.|.|:..|..||.|
Human    90 TLADTAVAAQVNGEPYDLERPLETDSDLRFLTFDSPEGKAVFWHSSTHVLGAAAEQFLGAVLCRG 154

  Fly   203 PPIENGFYYDMHLEGE-GISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRIL 266
            |..|.|||:|..|..| .|..::...:|.:.:::....:.|.|||..:..|.::||.|.||:.::
Human   155 PSTEYGFYHDFFLGKERTIRGSELPVLERICQELTAAARPFRRLEASRDQLRQLFKDNPFKLHLI 219

  Fly   267 NEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDP 331
            .||||....|||.||:|:|||:|||:||||::..||:..|||:.|......||||||.|||||..
Human   220 EEKVTGPTATVYGCGTLVDLCQGPHLRHTGQIGGLKLLSNSSSLWRSSGAPETLQRVSGISFPTT 284

  Fly   332 KQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQ 396
            :.|:.||..:|||..||||:||:|||||||||||||||||.|||..:||.|:.||:|||..|||.
Human   285 ELLRVWEAWREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYAHRGFS 349

  Fly   397 EVISPNIYNAKLWMTSGHWQHYAENMFSFEAE-----------------KEKFALKPMNCPGHCL 444
            ||.:|.:::.|||..||||:||.|:||:.:..                 .:..||||||||.|||
Human   350 EVKTPTLFSTKLWEQSGHWEHYQEDMFAVQPPGSDRPPSSQSDDSTRHITDTLALKPMNCPAHCL 414

  Fly   445 IFDNRNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFL 509
            :|.:|.|||||||||:||||.|||.|.||.|.||||:|.||||||||||..:|:::|::.||:||
Human   415 MFAHRPRSWRELPLRLADFGALHRAEASGGLGGLTRLRCFQQDDAHIFCTTDQLEAEIQSCLDFL 479

  Fly   510 KYVYTIFGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITI 574
            :.||.:.||||:|.|||||..:||:...|:.||:.|.::|.|||.||..|.|||||||||||:.:
Human   480 RSVYAVLGFSFRLALSTRPSGFLGDPCLWDQAEQVLKQALKEFGEPWDLNSGDGAFYGPKIDVHL 544

  Fly   575 MDALKRAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPF 639
            .|||.|.|||.|||||||||:||:|.|....|..:|||:||||:||||||::.:|.|:..||||.
Human   545 HDALGRPHQCGTIQLDFQLPLRFDLQYKGQAGALERPVLIHRAVLGSVERLLGVLAESCGGKWPL 609

  Fly   640 WLSPRQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDK 704
            ||||.||:|:|||...::||:..:..|..||.:|:.|.|:|.|::::||.||||.:||..|||.|
Human   610 WLSPFQVVVIPVGSEQEEYAKEAQQSLRAAGLVSDLDADSGLTLSRRIRRAQLAHYNFQFVVGQK 674

  Fly   705 ERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANED 745
            |:|..|||:|||||:..||..:.|.:.:|.::::..:.|.:
Human   675 EQSKRTVNIRTRDNRRLGEWDLPEAVQRLVELQNTRVPNAE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	350/681 (51%)
		TGS_ThrRS_N	109..170	CDD:133437	31/60 (52%)
		tRNA_SAD	276..323	CDD:197931	26/46 (57%)
		ThrRS_core	347..643	CDD:238394	184/312 (59%)
		ThrRS_anticodon	643..734	CDD:238437	42/90 (47%)
TARS2	NP_079426.2	PLN02908	17..710	CDD:178496	351/684 (51%)
		TGS_ThrRS_N	61..122	CDD:133437	31/60 (52%)
		tRNA_SAD	229..>252	CDD:197931	16/22 (73%)
		ThrRS_core	300..613	CDD:238394	184/312 (59%)
		ThrRS_anticodon	613..704	CDD:238437	42/90 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53577
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760