DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ThrRS and Tars2

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_082207.2	Gene:	Tars2 / 71807	MGIID:	1919057	Length:	723	Species:	Mus musculus

Alignment Length:	687	Identity:	356/687 - (51%)
Similarity:	479/687 - (69%)	Gaps:	21/687 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PKYIEERNVFWEKCKAEYEAELAA---KKREPIKVTLPDGKQVDATSWETTPYEVARGISQGLAD 141
            |.::.||...:|:....:..:||:   ||...||::||:|::|||.:|.||||::|..||..|||
Mouse    34 PHWLAERFGLFEELWTAHVKKLASMTQKKARAIKISLPEGQKVDAVAWNTTPYQLAHQISVTLAD 98

  Fly   142 NTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIE 206
            ..|.::||||::||||.||.:|.|:.|.||.||.:|||||||||::|.|.|:..|..||.||..|
Mouse    99 TAVAAEVNGELYDLDRPLETDCHLRFLTFDSPEGKAVFWHSSAHVLGAAAEQQLGAVLCRGPSTE 163

  Fly   207 NGFYYDMHLEGE-GISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKV 270
            :|||:|..|..| .:.:.:...:|.:.::::...|.|.|||..:..|.::||.|.||:.::.|||
Mouse   164 SGFYHDFFLGKERTVRSAELPILERICQELIAAAQPFRRLEASRDQLRQLFKDNHFKLHLIEEKV 228

  Fly   271 TTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLK 335
            |....|||.||..:|||||||:||||::.|||:..|||..|......||||||.|||||..:.|:
Mouse   229 TGPTATVYGCGMSVDLCRGPHLRHTGQIGALKLLTNSSALWRSLGAPETLQRVSGISFPKVELLR 293

  Fly   336 EWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVIS 400
            .||..:|.|..||||:||:|||||||||||||||||.|||..:||.|:.||:|||.:|||.||.:
Mouse   294 NWEARREAAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRVYNALVAFIRAEYARRGFSEVKT 358

  Fly   401 PNIYNAKLWMTSGHWQHYAENMFSFE-----------------AEKEKFALKPMNCPGHCLIFDN 448
            |.:::.|||..||||:||..:|||.:                 ..|:..||||||||.|||:|.:
Mouse   359 PTLFSTKLWEQSGHWEHYRADMFSLKPPGTDGVDNSQSGHPARCPKDTLALKPMNCPAHCLMFAH 423

  Fly   449 RNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVY 513
            |.|||||||:|:||||.|||.|.||:|.||||:.|||||||||||||.|:::|::|||:||:.||
Mouse   424 RPRSWRELPVRLADFGALHRAEASGSLGGLTRLWRFQQDDAHIFCAPHQLEAEIQGCLDFLRCVY 488

  Fly   514 TIFGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDAL 578
            ::.||||.|.|||||..:|||...|:.||:.|.::|.:||.||..|||||||||||||:.:.|||
Mouse   489 SVLGFSFHLALSTRPPGFLGEPRLWDQAEQVLQQALEKFGEPWDLNPGDGAFYGPKIDVHLHDAL 553

  Fly   579 KRAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSP 643
            .|.|||.|||||||||:||:|.|....|..:.||:||||:||||||::.:|.|:..||||.||||
Mouse   554 GRPHQCGTIQLDFQLPLRFDLQYKGPAGTPECPVLIHRAVLGSVERLLGVLAESCGGKWPLWLSP 618

  Fly   644 RQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSS 708
            .||:|:||....::||:.|:..|..||.:|:.|.|:|.|:::::|.||||.:||..|||.:|:|.
Mouse   619 LQVVVIPVRTEQEEYARQVQQCLQAAGLVSDLDADSGLTLSRRVRRAQLAHYNFQFVVGQREQSQ 683

  Fly   709 NTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANED 745
            .|||||||||:..||..:||.:.:|.::::..:.|.:
Mouse   684 RTVNVRTRDNRQLGERDLAESVQRLLELQNARVPNAE 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	355/680 (52%)
		TGS_ThrRS_N	109..170	CDD:133437	33/60 (55%)
		tRNA_SAD	276..323	CDD:197931	27/46 (59%)
		ThrRS_core	347..643	CDD:238394	187/312 (60%)
		ThrRS_anticodon	643..734	CDD:238437	42/90 (47%)
Tars2	NP_082207.2	PLN02908	27..715	CDD:178496	355/680 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53577
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750