Protein Alignment ThrRS and Tars2

DIOPT Version :10

• Sequence 1: NP_723725.1
• Gene: ThrRS / 45784
• FlyBaseID: FBgn0027081
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_001014062.1
• Gene: Tars2 / 310672
• RGDID: 1308283
• Length: 723
• Species: Rattus norvegicus
• Alignment Length: 687
• Identity: 360/687 - (52%)
• Similarity: 478/687 - (69%)
• Gaps: 21/687 - (3%)

  Fly    80 PKYIEER-NVFWEKCKAEYE--AELAAKKREPIKVTLPDGKQVDATSWETTPYEVARGISQGLAD 141
            |.::.|| .:|.|...|:.:  |.:..||...||::||:|::|||.:|.||||::|:.||..|||
  Rat    34 PHWLAERFGLFEELWTAQVKRLASMTQKKARTIKISLPEGQKVDAVAWNTTPYQLAQQISSTLAD 98

  Fly   142 NTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIE 206
            ..|.::||||::||||.||.:|.|:.|.||.||.:||||.||||::|.|.|:..|..||.||..|
  Rat    99 TAVAAEVNGELYDLDRPLETDCHLRFLTFDSPEGKAVFWRSSAHVLGAAAEQHLGAVLCRGPSTE 163

  Fly   207 NGFYYDMHLEGE-GISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKV 270
            :|||.|..|..| .:.:.:...:|.:.::|:...|.|.|||..:..|.::||.|.||:.::.|||
  Rat   164 SGFYLDFFLGKERTVRSTELPTLERICQEIITAAQPFRRLEASRGQLRQLFKDNHFKLHVIEEKV 228

  Fly   271 TTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLK 335
            |....|||.||..:|||:|||:||||::.|||:..|||..|......||||||.|||||..:.|:
  Rat   229 TGTTATVYGCGMSVDLCQGPHLRHTGQIGALKLLTNSSALWRSSEAPETLQRVSGISFPKAELLR 293

  Fly   336 EWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVIS 400
            .||..:|||..||||:||:|||||||||||||||||.|||..|||.|:.||:|||.:|||.||.:
  Rat   294 NWEARREEAELRDHRRIGKEQELFFFHELSPGSCFFLPRGTRIYNALVAFIRAEYARRGFSEVKT 358

  Fly   401 PNIYNAKLWMTSGHWQHYAENMFSFE-----------------AEKEKFALKPMNCPGHCLIFDN 448
            |.:::.|||..||||:||..:|||.:                 ..|:..||||||||.|||:|.:
  Rat   359 PTLFSTKLWEQSGHWEHYRAHMFSLKPPGTDGVDSSQSGHPARCPKDTLALKPMNCPAHCLMFAH 423

  Fly   449 RNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVY 513
            |.|||||||:|:||||||||.|.||:|.||||:.|||||||||||||.|:::|::|||:||:.||
  Rat   424 RPRSWRELPVRLADFGVLHRAEASGSLGGLTRLWRFQQDDAHIFCAPSQLEAEIRGCLDFLRSVY 488

  Fly   514 TIFGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDAL 578
            ::.||||.|.|||||..:|||...|:.|||.|.::|.|||.||..|||||||||||||:.:.|||
  Rat   489 SVLGFSFHLALSTRPPGFLGEPHLWDQAEKVLQQALEEFGEPWNLNPGDGAFYGPKIDVHLHDAL 553

  Fly   579 KRAHQCATIQLDFQLPIRFNLSYIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSP 643
            .|.|||.|||||||||:||:|.|....|..:.||:||||:||||||::.:|.|:..|:||.||||
  Rat   554 GRPHQCGTIQLDFQLPLRFDLQYKGPAGAPECPVLIHRAVLGSVERLLGVLAESCGGRWPLWLSP 618

  Fly   644 RQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSS 708
            .||:|:||....:.||:.|:..|..||.:|:.|.|.|.|:::::|.||||.:||..|||.:|:|.
  Rat   619 FQVVVIPVRTEQEDYARQVQQCLQAAGLVSDLDADCGLTLSRRVRRAQLAHYNFQFVVGQREQSQ 683

  Fly   709 NTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANED 745
            .:||||||||:..||..:||.:.:|.:::|..:.|.:
  Rat   684 MSVNVRTRDNRQLGERGLAESVQRLLELQDARVPNAE 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_723725.1	PLN02908	79..740	CDD:178496	359/680 (53%)
Tars2	NP_001014062.1	PLN02908	34..715	CDD:178496	359/680 (53%)