DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ThrRS and Tars3

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_038968587.1	Gene:	Tars3 / 308701	RGDID:	1311308	Length:	790	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	467/754 - (61%)
Similarity:	571/754 - (75%)	Gaps:	44/754 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKLAPQGGRYYSQISRICQWILPKIQTQS--KPPKQQQQQQPQLKEQQQHSYATLAAKMKKEKKE 64
            |:||.|||              |..:..:  :||.|.|::.               .|.|:.|..
  Rat    73 LRLAEQGG--------------PGARRAAAHEPPTQNQEKD---------------TKRKRLKDS 108

  Fly    65 KPSGGGDTRKELSPLPKYIEERNVFWEKCKAEYEAELAAKKRE----PIKVTLPDGKQVDATSWE 125
            :|:      :|:.. |.:|:||...:|..|.:::...|.::::    .|.|.:..||.|....|:
  Rat   109 EPN------REVKQ-PNFIKERLQLFETLKTDHQLLPATQEKKNTNNVISVRVAGGKTVQGEEWK 166

  Fly   126 TTPYEVARGISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEA 190
            ||||:||.|||:.||:||||:||||.:|||||.|||:.|::||.||:.|||||:||||||::|||
  Rat   167 TTPYQVAAGISKELAENTVIAKVNGVLWDLDRPLEGDSTVELLMFDNEEAQAVYWHSSAHVLGEA 231

  Fly   191 MERIYGGHLCYGPPIENGFYYDMHLEGEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEM 255
            ||..|||||||||||||||||||.:....:|:.:..|:|.:.|.|:||||.|||||:.|..||||
  Rat   232 MELYYGGHLCYGPPIENGFYYDMFIGDRVVSSTELSALENICKTIIKEKQPFERLEVSKDSLLEM 296

  Fly   256 FKYNEFKVRILNEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETL 320
            ||||:||.|||.|||.|..||||:||.|||||:|||||||||:||:||.|||||||||..:.|||
  Rat   297 FKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIKIFKNSSTYWEGNPEMETL 361

  Fly   321 QRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGF 385
            ||||||||||.|.:::|||.||||..|||||||:||||||||:||||||||.||||.||||||.|
  Rat   362 QRVYGISFPDSKMMRDWEKFQEEARSRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLMDF 426

  Fly   386 IKAEYRKRGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRN 450
            |:.||.||.|.||:|||:||:|||.||||||||:.|||:|:.||:.|||||||||||||:|.:|.
  Rat   427 IREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDIEKDTFALKPMNCPGHCLMFAHRP 491

  Fly   451 RSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTI 515
            |||||:|:|.|||||||||||||.|||||||||||||||||||..|||:.|:||||.||:.||:.
  Rat   492 RSWREMPVRFADFGVLHRNELSGTLTGLTRVRRFQQDDAHIFCMVEQIEEEIKGCLHFLQSVYST 556

  Fly   516 FGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKR 580
            |||||||.|||||:::|||.|.|::||:.|..||..||.|||.||||||||||||||.|.||:.|
  Rat   557 FGFSFQLNLSTRPEHFLGETEIWDEAERQLQNSLTGFGKPWKINPGDGAFYGPKIDIKIKDAIGR 621

  Fly   581 AHQCATIQLDFQLPIRFNLSYIADDG-EKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPR 644
            .||||||||||||||||||:|::.|| :|.||||||||||||||||||||:||:.||||.|||||
  Rat   622 YHQCATIQLDFQLPIRFNLTYVSKDGDDKNRPVIIHRAILGSVERMIAILSENYGGKWPLWLSPR 686

  Fly   645 QVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSN 709
            |||::|||||.:.||..|..:..:.|||::.|.|...|:|||||||||||:|||||||:||:.:|
  Rat   687 QVMIIPVGPACENYALQVSKECFEEGFMADVDLDDSCTLNKKIRNAQLAQYNFILVVGEKEKLNN 751

  Fly   710 TVNVRTRDNKVHGEVSVAELITKLQKIRDEFIAN-EDSF 747
            :|||||||||:|||:|:..:|.||:.::.....| |:.|
  Rat   752 SVNVRTRDNKIHGEISITSVIEKLKNLKKSRTLNAEEEF 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	448/665 (67%)
		TGS_ThrRS_N	109..170	CDD:133437	36/60 (60%)
		tRNA_SAD	276..323	CDD:197931	36/46 (78%)
		ThrRS_core	347..643	CDD:238394	225/296 (76%)
		ThrRS_anticodon	643..734	CDD:238437	55/90 (61%)
Tars3	XP_038968587.1	PLN02908	99..783	CDD:178496	453/705 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336703
Domainoid	1	1.000	172	1.000	Domainoid score	I3624
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53577
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.660