Protein Alignment ThrRS and Tars3

DIOPT Version :10

• Sequence 1: NP_723725.1
• Gene: ThrRS / 45784
• FlyBaseID: FBgn0027081
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_758514.2
• Gene: Tars3 / 272396
• MGIID: 2444486
• Length: 790
• Species: Mus musculus
• Alignment Length: 772
• Identity: 471/772 - (61%)
• Similarity: 579/772 - (75%)
• Gaps: 48/772 - (6%)

  Fly    20 QWILPKIQ----TQSKPPKQQQQQQPQLKE------------------------QQQHSYATLAA 56
            :|:..::|    .|.:.|::.|.:.|:|..                        :|:.:.|..||
Mouse    23 RWLCAEVQRLRDEQLRGPERGQAEGPRLTREVAQLQAENRDLHQRLCGLRLRLAEQRRTEAGRAA 87

  Fly    57 ----------KMKKEKKEKPSGGGDTRKELSPLPKYIEERNVFWEKCKAEYEAELAAKKRE---- 107
                      |..|:|:.|.|..|...|:    |.:|:||...:|..|.:::...|.::::
Mouse    88 AHEPPTQNQEKDTKKKRLKQSEPGREVKQ----PNFIKERLQLFETLKTDHQLLPATQEKKNTNN 148

  Fly   108 PIKVTLPDGKQVDATSWETTPYEVARGISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDD 172
            .|.|.:..||.|....|:||||:||.|||:.||::|||:||||.:|||||.|||:.|::||.||:
Mouse   149 VISVRVAGGKTVQGERWKTTPYQVAAGISKELAEHTVIAKVNGVLWDLDRPLEGDSTVELLMFDN 213

  Fly   173 PEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFYYDMHLEGEGISTNDYGAMEGLVKQIVK 237
            .|||||:|||||||:|||||..|||||||||||||||||||.:|...:|:.:..|:|.:.|.|:|
Mouse   214 EEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRVVSSTELSALENICKTIIK 278

  Fly   238 EKQNFERLEMKKSDLLEMFKYNEFKVRILNEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALK 302
            |||.|||||:.|..||||||||:||.|||.|||.|..||||:||.|||||:|||||||||:||:|
Mouse   279 EKQPFERLEVSKDTLLEMFKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIK 343

  Fly   303 ITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPG 367
            |.|||||||||..:.|||||:|||||||.|.:|:|||.||||..|||||||:||||||||:||||
Mouse   344 IFKNSSTYWEGNPEMETLQRIYGISFPDSKMMKDWEKFQEEAKSRDHRKIGKEQELFFFHDLSPG 408

  Fly   368 SCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKEKF 432
            ||||.||||.|||.||.||:.||.||.|.||:|||:||:|||.||||||||:.|||:|:.||:.|
Mouse   409 SCFFLPRGAFIYNALMDFIREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDVEKDTF 473

  Fly   433 ALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQ 497
            ||||||||||||:|.:|.|||||:|:|.|||||||||||||.|:|||||||||||||||||..||
Mouse   474 ALKPMNCPGHCLMFAHRPRSWREMPVRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCMVEQ 538

  Fly   498 IKSEMKGCLEFLKYVYTIFGFSFQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGD 562
            |:.|:||||.||:.||:.|||||||.|||||:::|||:|.|::||:.|..||.|||.|||.||||
Mouse   539 IEEEIKGCLHFLQSVYSTFGFSFQLNLSTRPEHFLGEIEIWDEAERQLQNSLVEFGKPWKINPGD 603

  Fly   563 GAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLSYIADDG-EKKRPVIIHRAILGSVERMI 626
            ||||||||||.|.||:.|.||||||||||||||||||:|::.|| :|.|||||||||||||||||
Mouse   604 GAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKNRPVIIHRAILGSVERMI 668

  Fly   627 AILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQ 691
            |||:||:.||||.|||||||||:|||||.:.||..|..:..:.|||::.|.|...|:||||||||
Mouse   669 AILSENYGGKWPLWLSPRQVMVIPVGPACENYALQVSKECFEEGFMADVDLDDSCTLNKKIRNAQ 733

  Fly   692 LAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIAN-EDSF 747
            |||:|||||||:||:.:|.|||||||||:|||:|:|.:|.||:.::.....| |:.|
Mouse   734 LAQYNFILVVGEKEKINNAVNVRTRDNKIHGEISIASVIEKLKNLKKSRTLNAEEDF 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_723725.1	PLN02908	79..740	CDD:178496	450/665 (68%)
Tars3	NP_758514.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..117		10/40 (25%)
		PLN02908	108..783	CDD:178496	453/678 (67%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:29579307	774..780		2/5 (40%)