DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ThrRS and SPAC24C9.09

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_594034.2	Gene:	SPAC24C9.09 / 2541554	PomBaseID:	SPAC24C9.09	Length:	474	Species:	Schizosaccharomyces pombe

Alignment Length:	457	Identity:	197/457 - (43%)
Similarity:	280/457 - (61%)	Gaps:	37/457 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 VYGISF-PDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFI 386
            :|...| |.|...|.....|.|:...|||.|...|:|:....|:|||.||.|.|..|||.|:.|:
pombe    22 IYTARFGPTPFSTKANNLKQPESTLNDHRTIAARQKLYTTSILTPGSIFFLPHGTRIYNRLVDFL 86

  Fly   387 KAEYRKRGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKE--------KFALKPMNCPGHC 443
            :|:|:..||:|:|:|.|:...||..|||||:|.:.:|..|..:.        .:.||||||||||
pombe    87 RAQYQIHGFEEIITPLIFKKDLWEKSGHWQNYEKEIFRVEESRNVEDEHSNATYGLKPMNCPGHC 151

  Fly   444 LIFDNRNRSWRELPLRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEF 508
            :::.:..||::|||||.|||..|||||.||||:||||:|.|.|||.||||:||.||.|:|..|.|
pombe   152 IVYASTERSYKELPLRFADFSPLHRNEASGALSGLTRLRCFHQDDGHIFCSPESIKDEIKNTLTF 216

  Fly   509 LKYVYTIFGFS-FQLVLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDI 572
            :|.||::.|.: .:|.|||||:.::|.|:.||:||..|.|:|.|.|..|..|.|||||||||||:
pombe   217 VKQVYSLLGMNKLKLYLSTRPEEHIGSLDTWNEAENGLREALQESGETWIINEGDGAFYGPKIDV 281

  Fly   573 TIMDALKRAHQCATIQLDFQLPIRFNLSYIADDGEK-------KRPVIIHRAILGSVERMIAILT 630
            .:.||..:.||.|||||||.||.||.|.|..|.|:.       |:||:|||||.||:||.:.||.
pombe   282 MVADARGKWHQTATIQLDFNLPQRFKLYYRTDAGDNAGSEKLIKQPVMIHRAIFGSLERFMGILI 346

  Fly   631 ENFAGKWPFWLSPRQVMVVPVGPAYDQ---YAQSVRDQL-----HDAGFMS------EADCDA-G 680
            |:..|.||||||||..:::||... |:   ||:.|:.:|     :::.|:.      ..|.:| .
pombe   347 EHLNGHWPFWLSPRHAVILPVNQT-DRILTYAKQVQKELSNQEVNESEFLPLNKNTYYVDINAEA 410

  Fly   681 DTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRDEFIANED 745
            .::.|::|.::|..:|:.:|:|:.|.....::|.:|.|  |......::  .:|:::.|||.|..
pombe   411 QSIGKRLRESRLLNYNYEIVIGEDEVDKEILSVSSRHN--HNSRDTRKM--TIQQLKKEFIENVK 471

  Fly   746 SF 747
            ::
pombe   472 AY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	193/448 (43%)
		TGS_ThrRS_N	109..170	CDD:133437
		tRNA_SAD	276..323	CDD:197931	197/457 (43%)
		ThrRS_core	347..643	CDD:238394	161/311 (52%)
		ThrRS_anticodon	643..734	CDD:238437	23/105 (22%)
SPAC24C9.09	NP_594034.2	ThrRS_core	48..359	CDD:238394	161/310 (52%)
		hisS	71..443	CDD:273080	170/372 (46%)
		HGTP_anticodon	359..471	CDD:294191	28/116 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910