DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ThrRS and TARS3

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_689547.2	Gene:	TARS3 / 123283	HGNCID:	24728	Length:	802	Species:	Homo sapiens

Alignment Length:	725	Identity:	471/725 - (64%)
Similarity:	563/725 - (77%)	Gaps:	27/725 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SKPPKQQQQQQPQLKEQQQHSYATLAAKMKKEKKEKPSGGGDTRKELSPLPKYIEERNVFWEKCK 94
            ::||..|.|.                 |..|:||.|.|   :...|:...|.:|:||...:|..|
Human    98 AQPPPSQSQD-----------------KDMKKKKMKES---EADSEVKHQPIFIKERLKLFEILK 142

  Fly    95 AEYEAELA--AKKREP---IKVTLPDGKQVDATSWETTPYEVARGISQGLADNTVISKVNGEVWD 154
            .:::..||  .||.:.   |.|.:.||:.|....|:||||:||..|||.||::|||:|||||:||
Human   143 KDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWD 207

  Fly   155 LDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFYYDMHLEGEG 219
            |||.|||:.:|:||.||:.|||||:|||||||:|||||..|||||||||||||||||||.:|...
Human   208 LDRPLEGDSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRA 272

  Fly   220 ISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKVTTDRTTVYKCGSLI 284
            :|:.:..|:|.:.|.|:||||.|||||:.|..||||||||:||.|||||||.|..||||:||.||
Human   273 VSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLI 337

  Fly   285 DLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKLQEEAAKRDH 349
            |||:|||||||||:|.:||.|||||||||..:.|||||:|||||||.|.:::|||.||||..|||
Human   338 DLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDH 402

  Fly   350 RKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWMTSGH 414
            ||||:||||||||:||||||||.||||.|||||..||:.||.||.|.||:|||:||:|||..|||
Human   403 RKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGH 467

  Fly   415 WQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGALTGLT 479
            ||||:||||:||.||:.|||||||||||||:|.:|.|||||:|:|.|||||||||||||.|:|||
Human   468 WQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLT 532

  Fly   480 RVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFSFQLVLSTRPDNYLGELEQWNDAEKA 544
            ||||||||||||||..|||:.|:||||:||:.||:.|||||||.|||||:|:|||:|.||:|||.
Human   533 RVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQ 597

  Fly   545 LAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLSYIADDG-EK 608
            |..||.:||.|||.||||||||||||||.|.||:.|.||||||||||||||||||:|::.|| :|
Human   598 LQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDK 662

  Fly   609 KRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQLHDAGFMS 673
            |||||||||||||||||||||:||:.||||||||||||||:||||..::||..|..:..:.|||:
Human   663 KRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMA 727

  Fly   674 EADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQKIRD 738
            :.|.|...|:|||||||||||:|||||||:||:..|.|||||||||:|||:.|...|.||:.:|.
Human   728 DVDLDHSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRK 792

  Fly   739 EFIAN-EDSF 747
            ....| |::|
Human   793 TRTLNAEEAF 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	457/666 (69%)
		TGS_ThrRS_N	109..170	CDD:133437	36/60 (60%)
		tRNA_SAD	276..323	CDD:197931	35/46 (76%)
		ThrRS_core	347..643	CDD:238394	229/296 (77%)
		ThrRS_anticodon	643..734	CDD:238437	55/90 (61%)
TARS3	NP_689547.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..123		10/44 (23%)
		PLN02908	122..795	CDD:178496	458/672 (68%)
		TGS_ThrRS_N	162..223	CDD:133437	36/60 (60%)
		tRNA_SAD	329..376	CDD:197931	35/46 (76%)
		ThrRS_core	400..697	CDD:238394	229/296 (77%)
		ThrRS_anticodon	697..788	CDD:238437	55/90 (61%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8BLY2	786..792		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142992
Domainoid	1	1.000	341	1.000	Domainoid score	I1085
eggNOG	1	0.900	-	-		E1_COG0441
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1064	1.000	Inparanoid score	I250
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53577
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	1	1.000	-	-		otm40485
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1457
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800