DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ThrRS and tars2

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_021322466.1	Gene:	tars2 / 100333765	ZFINID:	ZDB-GENE-070815-3	Length:	687	Species:	Danio rerio

Alignment Length:	665	Identity:	331/665 - (49%)
Similarity:	453/665 - (68%)	Gaps:	7/665 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 KYIEERNVFWEKCKAEYEAELAAKKREPIKVTLPDGKQVDATSWETTPYEVARGISQGLADNTVI 145
            |.:.||...::..:........:.....:.:.|.||:.|..::..|:|.::||  |:.:. ..|:
Zfish    28 KLVHERLQVFQSLRDRLLKASGSPSGRDLAIRLADGRTVKGSAGVTSPLQIAR--SERVT-GAVV 89

  Fly   146 SKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFY 210
            |:||||:|.|.|.|..:|.||||.||..|.:.|.|.:.|.::...:||::...:|.....:.|.|
Zfish    90 SRVNGELWALSRPLLEDCDLQLLGFDSLEGKQVVWRTGACVLASVLERVFSAGVCREGVSDTGLY 154

  Fly   211 YDMHLEGEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKVTTDRT 275
            .|..|:...||..:   :|...||:...|.....||:...||.|:|:.|..::::..|::..|..
Zfish   155 CDYQLQDSSISLLE---VEQACKQVAAGKIPITTLELTLQDLKELFQDNAVRLQLAEEQMMGDTV 216

  Fly   276 TVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKL 340
            .|::||..:.:|.|..:.|||.:||.|:.:.|.....|.::|..:.|:.|:|||..::.::|||.
Zfish   217 GVFRCGDSVGVCSGLLLPHTGFLKAFKMLQVSPVTLSGSSEASGILRMIGVSFPSEREREQWEKE 281

  Fly   341 QEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYN 405
            ||||.:||||:||:.|||||||::|||||||.|:||||||||..|||:|||:|||.||::|.:::
Zfish   282 QEEARRRDHRRIGKAQELFFFHDVSPGSCFFMPKGAHIYNTLTDFIKSEYRRRGFSEVVTPTLFS 346

  Fly   406 AKLWMTSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNE 470
            ..||..|||||||:|||||..:|...|||||||||.||::|:.|.|||||:|:|.||||.|||||
Zfish   347 TALWERSGHWQHYSENMFSVSSETHTFALKPMNCPAHCVMFEQRLRSWREMPIRWADFGALHRNE 411

  Fly   471 LSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFSFQLVLSTRPDNYLGEL 535
            .||.|.||||||||.||||||||.|||::.|:..||:|::.||.:|||||..:|||||.:.:|:.
Zfish   412 ASGTLGGLTRVRRFCQDDAHIFCTPEQLEQEITACLDFVRSVYRVFGFSFHCLLSTRPASSMGDS 476

  Fly   536 EQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLS 600
            ..|:.||:.|..||..|...|:.||||||||||||||.|.|||.|.||||||||||||||||||.
Zfish   477 ALWDCAEQQLESSLKLFQERWELNPGDGAFYGPKIDILIRDALGRQHQCATIQLDFQLPIRFNLQ 541

  Fly   601 YIADDGEKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQ 665
            |:..||:.|||::||||:|||:|||||||.|||.|||||||||.||||||||.:.:.|||.|..:
Zfish   542 YVGADGQMKRPIMIHRAVLGSLERMIAILAENFGGKWPFWLSPAQVMVVPVGGSSEAYAQQVVSR 606

  Fly   666 LHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELI 730
            |.:||||::.|.|.|:|:|||||:|||||:|:|.|||:||....||:||||..:..|:.::.:::
Zfish   607 LREAGFMADIDDDHGNTLNKKIRSAQLAQYNYIFVVGEKESECGTVSVRTRAGQQIGQKTLEDVM 671

  Fly   731 TKLQKIRDEFIANED 745
            ..|.:: .|..:||:
Zfish   672 KTLTQL-TETRSNEE 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	328/658 (50%)
		TGS_ThrRS_N	109..170	CDD:133437	24/60 (40%)
		tRNA_SAD	276..323	CDD:197931	14/46 (30%)
		ThrRS_core	347..643	CDD:238394	199/295 (67%)
		ThrRS_anticodon	643..734	CDD:238437	46/90 (51%)
tars2	XP_021322466.1	ThrS	33..682	CDD:333237	327/655 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820