DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ThrRS and tars3

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_021323393.1	Gene:	tars3 / 100330276	ZFINID:	ZDB-GENE-081104-490	Length:	860	Species:	Danio rerio

Alignment Length:	747	Identity:	479/747 - (64%)
Similarity:	587/747 - (78%)	Gaps:	29/747 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LPKIQTQSKPPKQQQQQQPQLK---------EQQQ---HSYATLAA----KMKKEKKEKPSGGGD 71
            :.|.:||.:..::|:.|:.|::         |:||   .|....||    :::|::|.|
Zfish   121 IKKQETQKQETQKQETQKQQIQKRPIQKQEIEKQQSRAQSSGCRAADEKERIRKQEKLK------ 179

  Fly    72 TRKELSPLPKYIEERNVFWEKCKAEYEA---ELAAKKREPIKVTLPDGKQVDATSWETTPYEVAR 133
            :.:|||..|.::..|...:|:.|.|.|.   |.||..|. |.|.|.||:.:.||:|.::||::|.
Zfish   180 SAEELSSWPSFVSARLDLYERLKKESEVLLEERAASGRS-ITVQLQDGQTLSATAWVSSPYQLAY 243

  Fly   134 GISQGLADNTVISKVNGEVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGH 198
            .||..||:|:||::||||:|||:|.|||:|:|:||:||..:||:|:||||||::|||||..|||.
Zfish   244 SISPALAENSVIARVNGELWDLERPLEGDCSLELLRFDHEDAQSVYWHSSAHVLGEAMESFYGGC 308

  Fly   199 LCYGPPIENGFYYDMHLEG-EGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFK 262
            |||||||:|||||||.|:| :.:|:.::..:|.:.:.|:||||.|||||:||..||||||||:||
Zfish   309 LCYGPPIDNGFYYDMFLDGHKAVSSTEFSDLELICRNIMKEKQPFERLEVKKETLLEMFKYNKFK 373

  Fly   263 VRILNEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGIS 327
            .||||||||||.||||:||.|||||||||||||||:||.||.|||||||||::|.|||||:||||
Zfish   374 CRILNEKVTTDTTTVYRCGPLIDLCRGPHVRHTGKIKAFKIYKNSSTYWEGRSDMETLQRIYGIS 438

  Fly   328 FPDPKQLKEWEKLQEEAAKRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRK 392
            |||.|.|||||:.||||..|||||||::|||||||:||||||||.||||.||||||.||:.||.:
Zfish   439 FPDSKMLKEWERFQEEAKNRDHRKIGKDQELFFFHDLSPGSCFFLPRGAFIYNTLMDFIRGEYSR 503

  Fly   393 RGFQEVISPNIYNAKLWMTSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELP 457
            ||||||.:|||||::||.||||||.|.::||||..|.:.|||||||||||||:|.:|.|||||||
Zfish   504 RGFQEVATPNIYNSRLWETSGHWQLYTQSMFSFPVELDVFALKPMNCPGHCLMFAHRPRSWRELP 568

  Fly   458 LRMADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFSFQL 522
            ||:|||||||||||||.|||||||||||||||||||..:||.|||||||:||:.||::|||||||
Zfish   569 LRLADFGVLHRNELSGTLTGLTRVRRFQQDDAHIFCTLDQIGSEMKGCLDFLRSVYSVFGFSFQL 633

  Fly   523 VLSTRPDNYLGELEQWNDAEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATI 587
            .|||||..:||:...||.|||.|..||||||.|||.||||||||||||||.|.||:.|.||||||
Zfish   634 HLSTRPQKFLGDEALWNQAEKQLENSLNEFGEPWKLNPGDGAFYGPKIDINIKDAIGRYHQCATI 698

  Fly   588 QLDFQLPIRFNLSYIADDG-EKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPV 651
            ||||||||||||:|:..|| ::.|||||||||||||||||||||||:|||||.||||||||:|||
Zfish   699 QLDFQLPIRFNLTYVGKDGDDRDRPVIIHRAILGSVERMIAILTENYAGKWPLWLSPRQVMLVPV 763

  Fly   652 GPAYDQYAQSVRDQLHDAGFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTR 716
            .|:.::||:.|..:..:||||::||.|:...:|||||||||||:|||||||:|||.||:||||||
Zfish   764 NPSLEEYAKQVCKRFVEAGFMADADLDSSCLLNKKIRNAQLAQYNFILVVGEKERLSNSVNVRTR 828

  Fly   717 DNKVHGEVSVAELITKLQKIRDEFIAN-EDSF 747
            |||||||:.|.|::.:|..:|.....| ||.|
Zfish   829 DNKVHGELPVLEVMERLMLLRRSQCRNAEDDF 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	457/665 (69%)
		TGS_ThrRS_N	109..170	CDD:133437	33/60 (55%)
		tRNA_SAD	276..323	CDD:197931	38/46 (83%)
		ThrRS_core	347..643	CDD:238394	228/296 (77%)
		ThrRS_anticodon	643..734	CDD:238437	57/90 (63%)
tars3	XP_021323393.1	ThrS	179..851	CDD:333237	461/678 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	335	1.000	Domainoid score	I1097
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100294
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920