DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ThrRS and tars3

DIOPT Version :9

Sequence 1:	NP_001285868.1	Gene:	ThrRS / 45784	FlyBaseID:	FBgn0027081	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001096223.1	Gene:	tars3 / 100124774	XenbaseID:	XB-GENE-5954362	Length:	814	Species:	Xenopus tropicalis

Alignment Length:	718	Identity:	491/718 - (68%)
Similarity:	579/718 - (80%)	Gaps:	12/718 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PPKQQQQQQPQLKEQQQHSYATLAAKMK------KEKKEKPSGGG-DTRKELSP-LPKYIEERNV 88
            |.::.:||..:.||:.|.:....:...|      .:|.||.:|.. |..|:..| .|.:|::|..
Frog    86 PVEEPKQQNNKAKEKGQATKGENSVGGKPSACEGNKKNEKKAGKEVDGHKQEGPCAPGFIKDRLA 150

  Fly    89 FWEKCKAEYEAELAAK---KREPIKVTLPDGKQVDATSWETTPYEVARGISQGLADNTVISKVNG 150
            .:|..|.|::|.|||:   :.:|||:||.||||||..||:||||:||.|||:|||||.||:|||.
Frog   151 LYETLKNEHDALLAARAAHQSKPIKITLADGKQVDGESWKTTPYQVAIGISKGLADNVVIAKVNN 215

  Fly   151 EVWDLDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPIENGFYYDMHL 215
            |:|||||.||.:..::|||||..|||||:|||||||:||.||..|||.|||||||||||||||:|
Frog   216 ELWDLDRPLEQDSNVELLKFDSEEAQAVYWHSSAHILGETMENFYGGCLCYGPPIENGFYYDMYL 280

  Fly   216 EGEGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEMFKYNEFKVRILNEKVTTDRTTVYKC 280
            :|.|:|:|::.::|.:.|.|:||||.|||||:.|..||||||||:||.|||||||.|..||||:|
Frog   281 DGRGVSSNEFPSLENMCKAIIKEKQPFERLEVSKDLLLEMFKYNKFKCRILNEKVDTPTTTVYRC 345

  Fly   281 GSLIDLCRGPHVRHTGKVKALKITKNSSTYWEGKADAETLQRVYGISFPDPKQLKEWEKLQEEAA 345
            |.|||||||||||||||:|.|||.|||||||||:||.|||||:|||||||.|.:||||:.||||.
Frog   346 GPLIDLCRGPHVRHTGKIKTLKIYKNSSTYWEGRADMETLQRIYGISFPDSKLMKEWEQFQEEAK 410

  Fly   346 KRDHRKIGREQELFFFHELSPGSCFFQPRGAHIYNTLMGFIKAEYRKRGFQEVISPNIYNAKLWM 410
            .||||||||:|||||||:||||||||.||||||||||..|||.||:.|.|.||.||||||:|||.
Frog   411 NRDHRKIGRDQELFFFHDLSPGSCFFLPRGAHIYNTLTDFIKGEYQIRNFTEVASPNIYNSKLWE 475

  Fly   411 TSGHWQHYAENMFSFEAEKEKFALKPMNCPGHCLIFDNRNRSWRELPLRMADFGVLHRNELSGAL 475
            .|||||||:|||||||.|||.|||||||||||||:|.:|.|||||||||.|||||||||||||.|
Frog   476 MSGHWQHYSENMFSFEVEKETFALKPMNCPGHCLMFGHRPRSWRELPLRFADFGVLHRNELSGTL 540

  Fly   476 TGLTRVRRFQQDDAHIFCAPEQIKSEMKGCLEFLKYVYTIFGFSFQLVLSTRPDNYLGELEQWND 540
            :|||||||||||||||||..:||:.||.|||:||:.||.:|||:|||.|||||:|||||:|.||:
Frog   541 SGLTRVRRFQQDDAHIFCTMDQIQEEMNGCLQFLQSVYKVFGFTFQLHLSTRPENYLGEIEIWNE 605

  Fly   541 AEKALAESLNEFGMPWKENPGDGAFYGPKIDITIMDALKRAHQCATIQLDFQLPIRFNLSYIADD 605
            |||.|..|||:||.|||.||||||||||||||.|.||:.|.||||||||||||||||||:|::.|
Frog   606 AEKQLESSLNQFGEPWKLNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKD 670

  Fly   606 G-EKKRPVIIHRAILGSVERMIAILTENFAGKWPFWLSPRQVMVVPVGPAYDQYAQSVRDQLHDA 669
            | :||||||||||||||||||||||.||:.||||||||||||||:||||:.|:|||.|...:.:|
Frog   671 GDDKKRPVIIHRAILGSVERMIAILCENYGGKWPFWLSPRQVMVIPVGPSCDEYAQQVCKDVFEA 735

  Fly   670 GFMSEADCDAGDTMNKKIRNAQLAQFNFILVVGDKERSSNTVNVRTRDNKVHGEVSVAELITKLQ 734
            |||:|.|.|...|:|||||||||||.|||||||:||::.:.|||||||||||||:.:...|.||:
Frog   736 GFMAEVDLDHSCTLNKKIRNAQLAQCNFILVVGEKEKTDSAVNVRTRDNKVHGEILLTSAIEKLK 800

  Fly   735 KIR 737
            .::
Frog   801 TLK 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ThrRS	NP_001285868.1	PLN02908	79..740	CDD:178496	477/663 (72%)
		TGS_ThrRS_N	109..170	CDD:133437	41/60 (68%)
		tRNA_SAD	276..323	CDD:197931	39/46 (85%)
		ThrRS_core	347..643	CDD:238394	235/296 (79%)
		ThrRS_anticodon	643..734	CDD:238437	58/90 (64%)
tars3	NP_001096223.1	valS	<15..181	CDD:237855	29/94 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..142		14/55 (25%)
		PLN02908	142..807	CDD:178496	477/662 (72%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8BLY2	798..804		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1069	1.000	Inparanoid score	I250
OMA	1	1.010	-	-		QHG53577
OrthoDB	1	1.010	-	-		D109954at33208
OrthoFinder	1	1.000	-	-		FOG0001071
OrthoInspector	1	1.000	-	-		otm47665
Panther	1	1.100	-	-	O	PTHR11451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X643
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080