DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and VAS1

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_011608.1	Gene:	VAS1 / 852986	SGDID:	S000003326	Length:	1104	Species:	Saccharomyces cerevisiae

Alignment Length:	1055	Identity:	544/1055 - (51%)
Similarity:	708/1055 - (67%)	Gaps:	50/1055 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAPGEKKD 85
            |||.|::|||:.|||||.|..||..||.||| ..|..::||:|: |||:....:..:|.|||||.
Yeast    74 PKTPKEIEKEKKKAEKLLKFAAKQAKKNAAA-TTGASQKKPKKK-KEVEPIPEFIDKTVPGEKKI 136

  Fly    86 LSGALPD----AYSPRYVEAQWYSWWEKEGFFTPEY---GRASIDAPNPNGKFVMIIPPPNVTGS 143
            |. :|.|    ||:|..||:.||.||.|.|.|.||:   |:.     .|.|.|.:..|||||||:
Yeast   137 LV-SLDDPALKAYNPANVESSWYDWWIKTGVFEPEFTADGKV-----KPEGVFCIPAPPPNVTGA 195

  Fly   144 LHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIE 208
            ||:|||||.||:|::.||:||||:|.|::||.||||||||.||||.:|..::.:|||.|||.|:.
Yeast   196 LHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVG 260

  Fly   209 RIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSC 273
            ::|:|:.|...||..|::.||:||||:|.|||:.|:|.::|.|||||||:||.|||:|||||||.
Yeast   261 KVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSV 325

  Fly   274 TLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTA 338
            .|.:|||::||:..::..||.||:|||::|||||||..|||.|.||||::|:||||.||:.||||
Yeast   326 KLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYPVIGSDEKLIIATTRPETIFGDTA 390

  Fly   339 VAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLP 402
            |||||.|||||||||||:.|||..|::||:.| |.|||.|||||||||||||.|||..|||.||.
Yeast   391 VAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLE 455

  Fly   403 FITIFNDDGYIIGDYG-EFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLI 466
            ||.|..|||.:..:.| |:.|||||:.|||::|:||..|||....:|.|.:|.||||.|::|||:
Yeast   456 FINILTDDGLLNEECGPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLL 520

  Fly   467 KPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFT 531
            ||||:||.|:||..|.:.||.|::.|.|:.....::||:..|:|||:|||||||||.|.|.::.
Yeast   521 KPQWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINI- 584

  Fly   532 DPSLQTGSSAHGSVND--DEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIF 594
                      .|..:|  |..||:..||..||..|||.::  ..||..|:|||||||||||||::
Yeast   585 ----------EGEEHDRIDGDYWVAGRSMEEAEKKAAAKY--PNSKFTLEQDEDVLDTWFSSGLW 637

  Fly   595 PFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGR 659
            |||..|||::|||::||||.|:||||.|||||||.||:..|.||.|.:|||||:.|.:||||.||
Yeast   638 PFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGR 702

  Fly   660 KMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFAL 724
            ||||||||||||:|||.||.|:.|||:|:..||||||:||||.|||:.||.|||:||:||:||||
Yeast   703 KMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAMRFAL 767

  Fly   725 CAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQMDAWILSRL 789
            |||.|..|||||||.||.|||.||||::.||||||:......:.......|...:.::.|||.:|
Yeast   768 CAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNESLVEKWILHKL 832

  Fly   790 AAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYG 854
            ....:..|...:..||..:||:.|.|| |.:||||:|..|.:.|.||..::.:|:.|||:.||..
Yeast   833 TETSKIVNEALDKRDFLTSTSSIYEFW-YLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNA 896

  Fly   855 LRLLSPFMPFITEELYQRLPR--ANPAPSICVASYPSNTS-WRSTKIESDVEFVQKAARIIRSAR 916
            |:|:.||||||:||::||||:  ...|.||..||||...| :...|..:..:.|....:..||..
Yeast   897 LKLIHPFMPFISEEMWQRLPKRSTEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLL 961

  Fly   917 SDYNLPNKVKT-------EVYIVCTDSVPSEILKRYASDLATISYCSNVVFD-SPAPQGCAILTV 973
            |:||:....|.       |.:....|...|.:....|.|..|      ||.| |..|:||.:.:|
Yeast   962 SEYNILKNGKVFVESNHEEYFKTAEDQKDSIVSLIKAIDEVT------VVRDASEIPEGCVLQSV 1020

  Fly   974 TGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCES 1038
            ..:..||||:||.|:.|.||||:|||.::..::...:.|.|.:.||.||...:.:|||::||..:
Yeast  1021 NPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNT 1085

  Fly  1039 RAEIERIAAAIETLK 1053
            .||||.:.|.||.||
Yeast  1086 VAEIEGLEATIENLK 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	514/994 (52%)
		ValRS_core	129..736	CDD:185677	365/610 (60%)
		tRNA-synt_1_2	307..436	CDD:290334	87/130 (67%)
		Anticodon_Ia_Val	736..873	CDD:153416	58/136 (43%)
		Val_tRNA-synt_C	978..1053	CDD:287436	33/74 (45%)
VAS1	NP_011608.1	PTZ00419	128..1104	CDD:240411	517/999 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346276
Domainoid	1	1.000	791	1.000	Domainoid score	I5
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4587
Inparanoid	1	1.050	1038	1.000	Inparanoid score	I25
Isobase	1	0.950	-	0	Normalized mean entropy	S561
OMA	1	1.010	-	-		QHG53858
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	1	1.000	-	-		oto99067
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	LDO	PTHR11946
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1458
SonicParanoid	1	1.000	-	-		X1068
TreeFam	1	0.960	-	-
	16	15.740