DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and TWN2

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_172913.1	Gene:	TWN2 / 838023	AraportID:	AT1G14610	Length:	1108	Species:	Arabidopsis thaliana

Alignment Length:	1058	Identity:	513/1058 - (48%)
Similarity:	691/1058 - (65%)	Gaps:	63/1058 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KQLEKER-LKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAPGEKKDLSG 88
            |:|:|:: |:.|:||:|:||..|.....|....||......::|..|..| ..:|..||:|.||.
plant    71 KELKKQKALEKERLAELKAKQAKDGTNVPKKSAKKSSKRDASEENPEDFV-DPETPLGERKRLSS 134

  Fly    89 ALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNA 153
            .:...|||..||..||:||||...|       ..||.:....||:::|||||||:||:|||||:|
plant   135 QMAKQYSPATVEKSWYAWWEKSDLF-------KADAKSSKPPFVIVLPPPNVTGALHIGHALTSA 192

  Fly   154 IEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKG 218
            |||.|.|:.||.|...|||||.|||||||||||||.:.||..::|||:|||:|::.:|.|:.:.|
plant   193 IEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKIMRDRGMTRHDVGREEFVKEVWKWKNQYG 257

  Fly   219 GRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIE 283
            |.|..||:.||:|.||:|..||||.:..:|||||||||::||.|||..|||||.|.||:||||:|
plant   258 GTILTQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCILRTAISDVE 322

  Fly   284 VDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAVHPQDDRY 348
            |:.::|..:|.|.:||||..||||:|..|||.:||...|:||||||:||||||||:|:||.|.||
plant   323 VEYIDIKEKTLLKVPGYEKPVEFGLLTSFAYPLEGGLGEVIVATTRVETMLGDTAIAIHPDDARY 387

  Fly   349 KHLHGKFVVHPFSTRRLPIVCDE-FVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGY 412
            |||||||.||||:.|:|||:||. .||..||||.|||||||||||.|||||..|.||.||.|||.
plant   388 KHLHGKFAVHPFNGRKLPIICDGILVDPNFGTGCVKITPAHDPNDCEVGKRHKLEFINIFTDDGK 452

  Fly   413 IIGDYG-EFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSD 476
            |..:.| :|.||.||..|:.::|.|:...|||...||.|.:.:|||:.||:||:|||||||:||.
plant   453 INTNGGSDFAGMPRFAAREAVVEALQKQGLYRGAKNNEMRLGLCSRTNDVIEPMIKPQWYVNCSM 517

  Fly   477 MAASATEAVRSGE---LKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTG 538
            :...|.:...:.|   |:.:|:.:|..|..|::.|||||:||||||||||||::.:..:..|:
plant   518 IGKEALDVAITDENKKLEFVPKQYTAEWRRWLENIRDWCISRQLWWGHRIPAWYATLEEDQLK-- 580

  Fly   539 SSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPD 603
              ..|:.:|   :|:|||:|.:|..:||::|  ...|..|.:|.||||||||||:||.||.||||
plant   581 --EVGAYSD---HWVVARTEDDAREEAAQKF--LGKKFELTRDPDVLDTWFSSGLFPLSVLGWPD 638

  Fly   604 QTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNV 668
            .|.|.:.|||||:||||||||||||||||..|.||.|::||.:||.|||:|||||||||||||||
plant   639 VTDDFKAFYPTSVLETGHDILFFWVARMVMMGMKLGGEVPFSKVYFHPMIRDAHGRKMSKSLGNV 703

  Fly   669 IDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARD 733
            |||::||.|:||||||.:|...||||:|:..||.||.:|:|.||||||:|||||||.:|..|:..
plant   704 IDPLEVINGVTLEGLHKRLEEGNLDPKEVIVAKEGQVKDFPNGIPECGTDALRFALVSYTAQSDK 768

  Fly   734 INLDINRVLGYRFFCNKLWNATKFALLY----FTGSEKFDTELSASAAINQMDAWILSRLAAAIE 794
            |||||.||:|||.:|||||||.:||::.    :|..:....|....:.     .||||.|..||.
plant   769 INLDILRVVGYRQWCNKLWNAVRFAMMKLGDGYTPPQTLSPETMPFSC-----QWILSVLNKAIS 828

  Fly   795 ACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGS---EEQQTAARRTLYVCLDYGLR 856
            ......::::|:.|.:..||:|.|..||||:|.:||.|...:   ..::..|:..|::.|:.|||
plant   829 KTVVSLDAFEFSDAANTIYAWWQYQFCDVYIEAIKPYFAGDNPTFASERAHAQHALWISLETGLR 893

  Fly   857 LLSPFMPFITEELYQRLPRANPAP-------SICVASYPSN-TSWRSTKIESDVEFVQKAARIIR 913
            ||.|||||:||||:|||    |||       ||.:..|||. .:|.:.|:||:::.|....:.:|
plant   894 LLHPFMPFVTEELWQRL----PAPKDTERKASIMICDYPSAIENWSNEKVESEMDTVLATVKCMR 954

  Fly   914 SARSDYNLPNKVKTE---VYIVCTDSVPSEILKRYASDLATISYCSNVVFDS----PAPQGCAIL 971
            :.|:  .|..|.|.|   .:.:|.::|.|||:|.:..::.|::..|::...|    .||.|.::.
plant   955 ALRA--GLLEKQKNERLPAFALCENNVTSEIVKSHELEIRTLANLSSLEVVSKGQHAAPPGSSVE 1017

  Fly   972 TVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLC 1036
            ||....:|:|.:.|.:..:.|..|::.|..:|.:...||.:.:..:.|..||||.::|.|..||.
plant  1018 TVNENLKVYLEVDGAINTEAEQEKIRNKIGELQKQKEKLQKMMSVSTYEEKVPANIKEDNANKLA 1082

  Fly  1037 ESRAEIE-------RIAA 1047
            :...|.:       |:||
plant  1083 KILQEFDFFEKESARLAA 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	495/1002 (49%)
		ValRS_core	129..736	CDD:185677	360/611 (59%)
		tRNA-synt_1_2	307..436	CDD:290334	84/130 (65%)
		Anticodon_Ia_Val	736..873	CDD:153416	58/143 (41%)
		Val_tRNA-synt_C	978..1053	CDD:287436	22/77 (29%)
TWN2	NP_172913.1	PLN02381	41..1106	CDD:215214	513/1058 (48%)
		ValRS_core	168..771	CDD:185677	360/611 (59%)
		tRNA-synt_1_2	351..477	CDD:290334	82/125 (66%)
		Anticodon_Ia_Val	771..910	CDD:153416	58/143 (41%)
		Val_tRNA-synt_C	1034..1099	CDD:287436	17/64 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	772	1.000	Domainoid score	I10
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4587
Inparanoid	1	1.050	978	1.000	Inparanoid score	I46
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	1	1.000	-	-		oto3763
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840