DRSC/TRiP Functional Genomics Resources

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Protein Alignment ValRS and VARS1

DIOPT Version :9

Sequence 1:NP_001260946.1 Gene:ValRS / 45783 FlyBaseID:FBgn0027079 Length:1055 Species:Drosophila melanogaster
Sequence 2:XP_005249419.1 Gene:VARS1 / 7407 HGNCID:12651 Length:1265 Species:Homo sapiens


Alignment Length:1061 Identity:631/1061 - (59%)
Similarity:773/1061 - (72%) Gaps:27/1061 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 QNDANAPAGAGGDPPKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEA 71
            |....|||     .||||.||:||..|.|||.|.|.|...:....|...:||.|||||.|.....
Human   219 QPGPEAPA-----LPKTAAQLKKEAKKREKLEKFQQKQKIQQQQPPPGEQKKPKPEKREKRDPGV 278

  Fly    72 AVYTAQTAPGEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIP 136
            ..|...|.||||||:||.:||:||||||||.||.|||::|||.|||||.::.|.||.|.|:|.||
Human   279 ITYDLPTPPGEKKDVSGPMPDSYSPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIP 343

  Fly   137 PPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDL 201
            ||||||||||||||||||:|::||:|||:|.||||.||||||||||||||||.|||::.||||.|
Human   344 PPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQL 408

  Fly   202 GREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSS 266
            |||.|::.:|.|:.|||.|||.|||.||||.||.|..|||||||..|||||||||||||.||||:
Human   409 GREAFLQEVWKWKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRST 473

  Fly   267 RLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEG--SDEEIIVATTR 329
            |||||||||.||||||||||.|:.|||.||:|||::|||||||:.|||||:|  ||||::|||||
Human   474 RLVNWSCTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTR 538

  Fly   330 IETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYE 394
            |||||||.||||||:|.||:||.||.|:|||.:|.||||.||||||.|||||||||||||.||||
Human   539 IETMLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQNDYE 603

  Fly   395 VGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSK 459
            ||:|..|..|:|.:..|.:|.....|.|:.|||.||.:|..||...|:|...:||||||:|:|||
Human   604 VGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSK 668

  Fly   460 DVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIP 524
            ||||||::|||||.|.:||.:|:.||..|:|:|:||.|.:||:.|||.||:||:|||||||||||
Human   669 DVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWCISRQLWWGHRIP 733

  Fly   525 AYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWF 589
            ||.|:.:||::..|.      :.|.:||:..|:||||..|||:.|||...||.|:||||||||||
Human   734 AYFVTVSDPAVPPGE------DPDGRYWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWF 792

  Fly   590 SSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVR 654
            |||:||.|:.|||:|::||..|||.:|||||||||||||||||..|.||.|:|||:|||||.:||
Human   793 SSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLPFREVYLHAIVR 857

  Fly   655 DAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDA 719
            |||||||||||||||||:|||.||:|:|||.||:.|||||.|:||||.|||.|:|.||||||:||
Human   858 DAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDA 922

  Fly   720 LRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEK-FDTELSASAAINQ--M 781
            |||.||||::|.||||||:||:||||.|||||||||||||   .|..| |....::....::  :
Human   923 LRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFAL---RGLGKGFVPSPTSQPGGHESLV 984

  Fly   782 DAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRT 846
            |.||.|||..|:...|.||::|||.|.|:|.|:||||:|||||||||||:.....:.....||:|
Human   985 DRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQT 1049

  Fly   847 LYVCLDYGLRLLSPFMPFITEELYQRLPRANP--APSICVASY--PSNTSWRSTKIESDVEFVQK 907
            ||.|||.|||||||||||:||||:|||||..|  .||:||..|  ||..||:..:.|:.:|....
Human  1050 LYTCLDVGLRLLSPFMPFVTEELFQRLPRRMPQAPPSLCVTPYPEPSECSWKDPEAEAALELALS 1114

  Fly   908 AARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEI---LKRYASDLATISYCSNVVFDSPAPQGCA 969
            ..|.:||.|:|||| .:::.:.::...|.....:   :..|...||:....:.:...:|||||||
Human  1115 ITRAVRSLRADYNL-TRIRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCA 1178

  Fly   970 ILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETK 1034
            :...:.:|.:||.|:|||:..:|:.|||.|..:..:...:|.:...|:.|..|||.|||||:|.|
Human  1179 VALASDRCSIHLQLQGLVDPARELGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAK 1243

  Fly  1035 LCESRAEIERIAAAIETLKLM 1055
            |.::.||:.::..||...:.|
Human  1244 LQQTEAELRKVDEAIALFQKM 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ValRSNP_001260946.1 PTZ00419 80..1053 CDD:240411 600/984 (61%)
ValRS_core 129..736 CDD:185677 420/608 (69%)
tRNA-synt_1_2 307..436 CDD:290334 86/130 (66%)
Anticodon_Ia_Val 736..873 CDD:153416 80/139 (58%)
Val_tRNA-synt_C 978..1053 CDD:287436 29/74 (39%)
VARS1XP_005249419.1 GstA <56..203 CDD:223698
GST_C_ValRS_N 92..213 CDD:198327
PTZ00419 283..1265 CDD:240411 602/992 (61%)
ValRS_core 336..939 CDD:185677 420/608 (69%)
tRNA-synt_1_2 514..>610 CDD:290334 73/95 (77%)
Anticodon_Ia_Val 939..1076 CDD:153416 80/139 (58%)
Val_tRNA-synt_C 1197..1259 CDD:287436 22/61 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145655
Domainoid 1 1.000 934 1.000 Domainoid score I39
eggNOG 1 0.900 - - E1_COG0525
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4587
Inparanoid 1 1.050 1285 1.000 Inparanoid score I165
Isobase 1 0.950 - 0 Normalized mean entropy S561
OMA 1 1.010 - - QHG53858
OrthoDB 1 1.010 - - D229591at2759
OrthoFinder 1 1.000 - - FOG0001015
OrthoInspector 1 1.000 - - oto88614
orthoMCL 1 0.900 - - OOG6_100292
Panther 1 1.100 - - LDO PTHR11946
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1458
SonicParanoid 1 1.000 - - X1068
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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