Protein Alignment ValRS and IleRS

DIOPT Version :10

• Sequence 1: NP_001260946.1
• Gene: ValRS / 45783
• FlyBaseID: FBgn0027079
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_524840.2
• Gene: IleRS / 45785
• FlyBaseID: FBgn0027086
• Length: 1229
• Species: Drosophila melanogaster
• Alignment Length: 1138
• Identity: 250/1138 - (21%)
• Similarity: 393/1138 - (34%)
• Gaps: 299/1138 - (26%)

  Fly   107 WEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLW 171
            |..|..| .:..:.|...|    |:.....||..||..|.||.|...|:|.:|||...:|.....
  Fly    30 WRHENIF-EKCSQLSKGKP----KYTFYDGPPFATGLPHYGHILAGTIKDIVTRYAYQQGYHVDR 89

  Fly   172 VPGCDHAGIATQVVVEKLLWRDEK---------LSRHDLGREKFIERIWD-WRREKGGRIYEQLK 226
            ..|.|..|:..:..::|||  :.|         ::.::....|.:.|..| |.        ..:.
  Fly    90 RFGWDCHGLPVEFEIDKLL--NIKGPEDVAKMGIAAYNAECRKIVMRYADEWE--------NVVT 144

  Fly   227 SLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIE-------- 283
            .:|...|:.....|:.|....::...|.:|.::|.:|:..:::.:|....:::|:.|
  Fly   145 RVGRWIDFKNDYKTLYPWYMESIWWIFKQLFDKGLVYQGVKVMPYSTACTTSLSNFEANQNYKEV 209

  Fly   284 --------VDKVEIPGRTFL-------SIPGYEDKVEFGVLI--KFAY-KVEG--SDEEIIVATT 328
                    ::.|.:|...||       ::|.     .|...:  ...| ||..  ||...::|.:
  Fly   210 VDPCVVVALEAVSLPNTFFLVWTTTPWTLPS-----NFACCVHPTMTYVKVRDVKSDRLFVLAES 269

  Fly   329 RI-------------ETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTG 380
            |:             |..:|.|...:|     ||.|...|.......:...::.||:|....|||
  Fly   270 RLSYVYKSETEYEVKEKFVGKTLKDLH-----YKPLFPYFAKRGAEVKAYRVLVDEYVTEDSGTG 329

  Fly   381 AVKITPAHDPNDYEVGKRCNL-----PFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALN 440
            .|...|....:||.|.....|     ..:...::.|....:..:|.|....:..|:|:..|||
  Fly   330 IVHNAPYFGEDDYRVCLAAGLITKSSEVLCPVDEAGRFTNEASDFEGQYVKDSDKQIMAALKA-- 392

  Fly   441 LYRETLNNPMVV----PICSRSKDVVEPLI---KPQWYVSCSDMAASATEAVRSGELKIIPEH-H 497
              |..|.:...|    |.|.||.   .|||   .|.|:|....|:.:..:.  |.:...:|:. .
  Fly   393 --RGNLVSSGQVKHSYPFCWRSD---TPLIYKAVPSWFVRVEHMSKNLLDC--SSQTYWVPDFVK 450

  Fly   498 TKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEAL 562
            .|.:.:|:...|||.:||..:||..||.:.....|.::..||                      :
  Fly   451 EKRFGNWLKEARDWAISRNRYWGTPIPIWRSPSGDETVVIGS----------------------I 493

  Fly   563 TKAAERFGVDASKI------------------VLKQDEDVLDTWFSSGIFPFSVFGWP-DQTKDL 608
            .:.||..||....:                  .|::...|.|.||.||..||:...:| :..||.
  Fly   494 KQLAELSGVQVEDLHRESIDHIEIPSAVPGNPPLRRIAPVFDCWFESGSMPFAQQHFPFENEKDF 558

  Fly   609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMD 673
            ...:|...:..|.|....|...::.....|..|.|||.:....:|..|.|:||||...|..|||:
  Fly   559 MNNFPADFIAEGIDQTRGWFYTLLVISTALFNKAPFKNLIASGLVLAADGQKMSKRKKNYPDPME 623

  Fly   674 VIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDI 738
            |:.....:.|...|:.|                      |...:::|||.    ....|||..|:
  Fly   624 VVHKYGADALRLYLINS----------------------PVVRAESLRFK----EEGVRDIIKDV 662

  Fly   739 -----NRVLGYRFFCNKLWNATKFAL--LYFTGSEKFDTE--LSASAAINQMDAWILSRLAAAIE 794
                 |   .|||.   |.|..::..  |...|...:|.|  |......:.:|.||||...:.:|
  Fly   663 FLPWYN---AYRFL---LQNIVRYEKEDLAGNGQYTYDRERHLKNMDKASVIDVWILSFKESLLE 721

  Fly   795 ACNTGFESYDFAAATSACYAFWLYDLCDVYL--------------ECLKPIFQSGSEEQQTAARR 845
            ...|..:.|...........| :..|.:.|:              :|::.:             .
  Fly   722 FFATEMKMYRLYTVVPRLTKF-IDQLTNWYVRLNRRRIKGELGADQCIQSL-------------D 772

  Fly   846 TLYVCLDYGLRLLSPFMPFITEELYQRLPRANP------APSICVASYP-SNTSWRSTKIESDVE 903
            |||..|...:::::||.|::||.::|||....|      |.|:.....| |...:....||..|.
  Fly   773 TLYDVLYTMVKMMAPFTPYLTEYIFQRLVLFQPAGTLEHADSVHYQMMPVSQKKFIRNDIERSVA 837

  Fly   904 FVQKAARIIRSARSDYNLPNKVK-TEVYIVCTDSVPSEILK------------------------ 943
            .:|....:.|..|....||.|.. :|:..:..||...|.:|
  Fly   838 LMQSVVELGRVMRDRRTLPVKYPVSEIIAIHKDSQILEAIKTLQDFILSELNVRKLTLSSDKEKY 902

  Fly   944 -------------------RYASDLATISYCSNVVFDSPAPQG------------------CAIL 971
                               .:.:.:|.|....:........||                  |...
  Fly   903 GVTLRAEPDHKALGQRLKGNFKAVMAAIKALRDDEIQKQVSQGYFDILDQRIELDEVRIIYCTSE 967

  Fly   972 TVTGQCEVH----------------LLLKGLV-EADKEIAKLQKKSDQLVQTVGKLTQAIQAADY 1019
            .|.|..|.|                ||.:||. |....:.||:||: ||:.|...|.....|||
  Fly   968 QVGGNFEAHSDNEVLVLLDMTPNEELLEEGLAREVINRVQKLKKKA-QLIPTDPVLIFHELAAD- 1030

  Fly  1020 ATKVPAEVQEANE--TKLCESRAEIERIAAAIE 1050
             .|...||.||..  .|:..:.|.|.:.|...|
  Fly  1031 -NKAKQEVLEAQAQLAKVLSNYASIIKTAIKSE 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	250/1138 (22%)
IleRS	NP_524840.2	PLN02882	9..1094	CDD:215477	250/1138 (22%)