DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ValRS and LeuRS-m

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	181/969 - (18%)
Similarity:	301/969 - (31%)	Gaps:	298/969 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VEAQWYSWWEKE----GFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAIT 159
            :||.|     :|    |.|.|:         :...|:.::...|..:|:||:||.....|.|::.
  Fly    42 IEAHW-----REQLSGGQFNPK---------DSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVA 92

  Fly   160 RYHRMKGRTTLWVPGCDHAGI-----ATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGG 219
            |:.||.|:......|.|..|:     |.|..||...|.::.::
  Fly    93 RFQRMCGKNVFQPMGWDSFGLPAENAANQRGVEPASWTEQNIA---------------------- 135

  Fly   220 RIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEV 284
            ::.||||.||.|:||.....|..||..:.....|:.||..|..|::..||||....::.::|.:|
  Fly   136 QMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAYQNEALVNWDPVDKTVLADEQV 200

  Fly   285 D----------KVE--IPGRTFLSIPGYE----DKVE-----------------FGVLIKFAYKV 316
            |          |||  :..:.|:....|.    |.:|                 .|....:|:.:
  Fly   201 DANGCSWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLEDPTLRDWRDIINLQRHWIGECDGYAFNL 265

  Fly   317 EGSDEEII-VATTRIETMLGDTAVAVHPQDDRYKHLHGK---FVVHPFSTRRLPIVCDEFVDMAF 377
            ..|...:: |.||..|.:....|..|...:.....|.|.   ...:||:...:|:|..:.|....
  Fly   266 LTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKGADSLSAANPFAGTTMPVVFSDEVTFPP 330

  Fly   378 GTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLY 442
            .:......|:....|.::.....|.|
  Fly   331 KSDVYLAAPSFRGEDKDLWDSYGLAF--------------------------------------- 356

  Fly   443 RETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDG 507
                        .|..|| .|.|....|.:...::..:||.....|             |.....
  Fly   357 ------------TSNGKD-EESLSPANWEMLRKEVLQAATRLNVGG-------------YRVSSK 395

  Fly   508 IRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVD 572
            ::||.:|||.:||..||..|           ....|:|...|:...|:....::   ..|.|..|
  Fly   396 LKDWLISRQRYWGTPIPIVH-----------CQKCGAVPVPEEQLPVSLPPKDS---PKEAFLCD 446

  Fly   573 ASKIVLK---QDEDVLDTWFSSGIFPFSVFGWPDQTKDLQT-----FYPTSLLETG--HDILFFW 627
            ..|...|   ::.|.:||:..|..:........:..:...|     |.|..|...|  |.:|..:
  Fly   447 CPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDLYIGGKEHAVLHLY 511

  Fly   628 VARMVFFGQKLLGKLPFKEVYLHPMVR----------DAHGR----------------------- 659
            .||.:.......|..|..|.:...:|:          ...||
  Fly   512 YARFINHFLHSCGLSPTSEPFSRLLVQGMVMGRSFRVKGSGRYVPETEVEIVNAKKNQAVLKETK 576

  Fly   660 --------KMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECG 716
                    |||||..|.::|.|:..                                     |.|
  Fly   577 EPVVMTWEKMSKSKLNGVEPSDMFN-------------------------------------EYG 604

  Fly   717 SDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQM 781
            :|..|..:.|.:......|.......|...:..:||       |.....::...:.:||..:...
  Fly   605 TDTTRLIILADVAPTSHRNWSSATFPGILNWQKRLW-------LTLQDFQQAREDQTASDVVPTS 662

  Fly   782 DAWILSRLAAAIEACNTGFE----SYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTA 842
            :.: |:..|...:|.|...:    :|..|...|...: .:..|.:......|.:.:.|.:.::..
  Fly   663 EEF-LAEDAKLFDARNFYVKGATFNYRHAQQLSVAIS-KMQGLTNSLRRTPKHVLRHGKQFERAL 725

  Fly   843 ARRTLYVCLDYGLRLLSPFMPFITEELYQR---LP-RANPAPSICVASYPSNTSWRSTKIESDVE 903
            |.:.:         :|:|..|....||:.:   :| |.|||        .....|....:.....
  Fly   726 AAQII---------MLAPMAPHFASELWSKFVAIPGRLNPA--------SQELQWSEDVLAQRWP 773

  Fly   904 FVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDS 962
            .:..|          |||...:|...:..|...|     :|...|..|.|...::.|::
  Fly   774 DIDPA----------YNLDLSIKVNGFENCVIKV-----QRTHLDKVTHSDALDIAFNT 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	181/969 (19%)
		ValRS_core	129..736	CDD:185677	133/699 (19%)
		tRNA-synt_1_2	307..436	CDD:290334	20/132 (15%)
		Anticodon_Ia_Val	736..873	CDD:153416	22/143 (15%)
		Val_tRNA-synt_C	978..1053	CDD:287436
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	181/969 (19%)
		LeuRS_core	63..624	CDD:173906	133/698 (19%)
		Anticodon_Ia_like	624..747	CDD:299868	22/140 (16%)
		Anticodon_Ia_like	<723..799	CDD:299868	19/107 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840