DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and Vars2

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_998728.1	Gene:	Vars2 / 309596	RGDID:	1303122	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	1061	Identity:	501/1061 - (47%)
Similarity:	655/1061 - (61%)	Gaps:	78/1061 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GDPPKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTK--EVKEAAVYTAQTAP 80
            |.|.....:..|::...||.|.|:|.|          .||.:.|...||  ..||..:|...|.|
  Rat    36 GSPVSRRNREAKQKRLREKQAALEAGL----------AEKSKTPAVPTKAWSHKEVVLYEIPTRP 90

  Fly    81 GEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGK-FVMIIPPPNVTGSL 144
            |||||:||.||.||||:||||.||.||.:||||.||| :|.:  |...|: |.|.||||||||||
  Rat    91 GEKKDVSGPLPPAYSPQYVEAAWYQWWVREGFFKPEY-QARL--PQATGETFSMCIPPPNVTGSL 152

  Fly   145 HLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIER 209
            |:|||||.||:||..|:|||:|...||:||.||||||||.||||.|||:.::.||:|.||.|:..
  Rat   153 HIGHALTVAIQDAFVRWHRMRGDRVLWIPGSDHAGIATQAVVEKQLWRERRVRRHELSREDFLRA 217

  Fly   210 IWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCT 274
            :|.|::||||.|||||.:||:|.||.|..||||.....|||||||||::.|.:||:.:|||||||
  Rat   218 VWQWKQEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYDLGLLYRNRQLVNWSCT 282

  Fly   275 LRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGS-DEEIIVATTRIETMLGDTA 338
            ||||||||||:...:||||.|.:||....|.||:|:..|:.|:|. ..||:|.|||.||:.||.|
  Rat   283 LRSAISDIEVESRPLPGRTVLRLPGCPIPVSFGLLVSIAFPVDGDPGTEIVVGTTRPETLPGDVA 347

  Fly   339 VAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPF 403
            |||||.|.||.||||:.:.||.:.:.||::.|..|....||||||:||||.|.|.|:|.|..|..
  Rat   348 VAVHPDDPRYTHLHGRQLRHPLTGQHLPLITDTTVQPHVGTGAVKVTPAHSPADAEMGTRHGLTP 412

  Fly   404 ITIFNDDG---YIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPL 465
            :::..:||   .:.||:  ..|:.||..|:||:..|:...|:|....:|||:||||||.||||.|
  Rat   413 LSVIAEDGTMTSLCGDW--LQGLHRFVAREKIMCTLRERGLFRGLQEHPMVLPICSRSGDVVEYL 475

  Fly   466 IKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSF 530
            :|.||:|.|.:|...|.:||.||.|::.|..|.|:|.||...|.||||||||||||:||||.|.
  Rat   476 LKSQWFVRCQEMGDRAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQIPAYRVG- 539

  Fly   531 TDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFP 595
                   |..|.   :|.|:.|:|.||||||...||::.|...:::.|::|.|||||||||.:||
  Rat   540 -------GEKAE---DDREECWVVGRSEAEARAAAAKQTGRPEAELTLERDPDVLDTWFSSALFP 594

  Fly   596 FSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRK 660
            ||..|||.:|.||..|||.:|||||.|:|.|||.|||..|.:|.|:|||.:|.||.||||..|||
  Rat   595 FSALGWPQETPDLARFYPLTLLETGSDLLTFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRK 659

  Fly   661 MSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALC 725
            ||||||||:||.|:|.|..|:.|.|:|...|||..|:..|.|.||:|:|.||||||:||||||||
  Rat   660 MSKSLGNVLDPRDIISGQELQVLQAKLRDGNLDQGELAVAAAAQKKDFPYGIPECGTDALRFALC 724

  Fly   726 AYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQMDAWILSRLA 790
            ::.....|::|.::.||.||.||||||||.:| :|...|.:............:.||||||||||
  Rat   725 SHGILGGDLHLSVSEVLNYRHFCNKLWNALRF-ILRALGDDFVPQPAEKVTPSSPMDAWILSRLA 788

  Fly   791 AAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGL 855
            .|...|..||.|.:.:..|...|.|||::|||||||.:||:..|.  .......:.|:.|.|.||
  Rat   789 FAANECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSA--PCPPGPPQVLFSCADVGL 851

  Fly   856 RLLSPFMPFITEELYQRLP---RANPAPSICVASYPS--------NTSWRSTKIESDVEFVQKAA 909
            |||:|.|||:.|||:||||   ..:.|||||||.|||        ..|||..::|.....||:..
  Rat   852 RLLAPLMPFLAEELWQRLPPRQGGSMAPSICVAPYPSGHSLVSRGQESWRQPELEHCFSRVQEIV 916

  Fly   910 RIIRSARSDYNLPNKVKTEVYIVCTDSVPSE--ILKRYASDLATISYCSNVVFDSP---APQGCA 969
            :.:|:.|:.|.|   .:...:::...|.|.|  :::.:...|..:|:|..|.|..|   ||.|.|
  Rat   917 QALRALRATYQL---TRARPHVLLQSSDPGEQGLVQPFLEPLGVLSHCGAVGFLPPGAAAPSGWA 978

  Fly   970 ILTVTGQCEVHLLLKGLVEADKEI-------AKLQKKSDQLV-QTVG---------------KLT 1011
            :..:....::::.|:|||:...::       .||||:.|.|: :||.               :|:
  Rat   979 LAPLGDTIKIYMELQGLVDPQSQLPRLAARRQKLQKQLDDLLNRTVSDGPAERQQRISSLQLELS 1043

  Fly  1012 QAIQAADYATKVPAEVQEANE 1032
            :..|||.:..::..|..:|.|
  Rat  1044 KLDQAASHLQQLMEEAPDARE 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	483/997 (48%)
		ValRS_core	129..736	CDD:185677	335/611 (55%)
		tRNA-synt_1_2	307..436	CDD:290334	60/132 (45%)
		Anticodon_Ia_Val	736..873	CDD:153416	62/136 (46%)
		Val_tRNA-synt_C	978..1053	CDD:287436	19/78 (24%)
Vars2	NP_998728.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..52		3/15 (20%)
		PTZ00419	86..1055	CDD:240411	481/990 (49%)
		ValRS_core	137..735	CDD:185677	334/610 (55%)
		'HIGH' region	146..156		8/9 (89%)
		'KMSKS' region	659..663		3/3 (100%)
		Anticodon_Ia_Val	735..869	CDD:153416	62/136 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11604
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.930