Protein Alignment ValRS and vrs2

DIOPT Version :10

• Sequence 1: NP_001260946.1
• Gene: ValRS / 45783
• FlyBaseID: FBgn0027079
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_593819.1
• Gene: vrs2 / 2543603
• PomBaseID: SPAC4A8.08C
• Length: 950
• Species: Schizosaccharomyces pombe
• Alignment Length: 950
• Identity: 338/950 - (35%)
• Similarity: 489/950 - (51%)
• Gaps: 97/950 - (10%)

  Fly   121 SIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVV 185
            ||:||    .|.:::||||:||.||:|||||..|:||:.|::.|.|....:.||.||||||||.|
pombe    54 SIEAP----MFPILLPPPNITGKLHIGHALTITIQDALARFYAMHGYKVSFRPGTDHAGIATQSV 114

  Fly   186 VEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVT 250
            |||.| :.:.:.|:.|.:::.:..|..|:.:....|..||||..:.:||..:.:|||.....||.
pombe   115 VEKYL-QKKGVYRNQLSKDELLSSIHSWQVKYQKSIINQLKSFEAIFDWDNIFYTMDQNRSEAVN 178

  Fly   251 EAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEI--PGRTFLSIPGYEDK--VEFGVLIK 311
            |||:.|...|.|||::|.|||...|.||:|||||:..:|  |      :..|.|.  ||||.|.:
pombe   179 EAFISLFNAGLIYRANRFVNWCPKLESAVSDIEVESQQINKP------VTKYVDNTPVEFGWLYE 237

  Fly   312 FAYKVEGSD-EEIIVATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHP-FSTRRLPIVCDEFVD 374
            .:|::|||| |::.|:|||.||:.||.|:||.|.|:|||...|:||.|| .....:|::||..||
pombe   238 ISYQLEGSDNEQLNVSTTRPETIFGDRAIAVSPHDERYKKYVGRFVKHPLIDDLLIPVICDNAVD 302

  Fly   375 MAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKAL 439
            ..||||.:||||.|...|||:.||.|:..::|.:..|.:|....|..||.|.:.|.||:..|:..
pombe   303 RHFGTGVLKITPMHSIVDYEIAKRHNIDCVSIMDKSGNLINCSKEVNGMNRLKARSKIVRLLQQR 367

  Fly   440 NLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHW 504
            |...|.:.:.:::.:|||:.||:||::.||||:|...:.....::  |.:||::|....|.|..|
pombe   368 NRLVEQVPHSLILSVCSRTGDVIEPVMVPQWYLSVDSLKKEVLKS--SNKLKLVPSLARKEWDSW 430

  Fly   505 MDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERF 569
            ...:.|||:|||:||||:||.:.:.                  :|..||.|.:..:||     :.
pombe   431 FKKMGDWCISRQIWWGHQIPVWKIL------------------EEDKWIAAPNYEKAL-----QL 472

  Fly   570 GVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFF 634
            .|..|   :.||.|||||||||.:.|.|.|||| ::||:|   |...:|:|.||||||:|||...
pombe   473 SVGKS---VSQDSDVLDTWFSSALLPLSAFGWP-KSKDIQ---PLPFIESGQDILFFWIARMALL 530

  Fly   635 GQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEK 699
            .:....:|||||:.|||:|||:.||||||||||||||||:|.|:|||.:...|:..||...|:.|
pombe   531 CKYFSNELPFKEIILHPLVRDSEGRKMSKSLGNVIDPMDIINGVTLENMKKALLEGNLPISEVHK 595

  Fly   700 AKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTG 764
            :....::.:|.|||..|.|..|:.|...:...:.|.||:|.......|.:||||..::...|...
pombe   596 SSKQMEKAFPNGIPAQGIDIFRYGLFLCLHHEQRILLDMNSFSDAHRFVSKLWNLARYFNQYKDK 660

  Fly   765 SEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLK 829
            ........|....|:.:.....|:|..|:|.....||...|..|......|.|.||..||:| |.
pombe   661 ENPLKLTDSQRQRISLLKMATYSKLHHAVEGVKESFEQRKFFNAADIMKNFLLNDLSSVYVE-LT 724

  Fly   830 PIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQR--LPRANPAPSICVASYPSNTS 892
            ......|:.......|.....|...|:|:.|.:|.|:..:...  :|....:..:   |:|  ||
pombe   725 RFDVKDSKSSAYEVYRVFSDILHIFLKLIHPIVPCISGVMLHSKIIPERKNSEFL---SFP--TS 784

  Fly   893 WRSTKIESDVE---FVQKAARI---IRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRY------ 945
            .:...:..|.:   .||.|..:   :|...|..|.....:..|||    |...|.||.:
pombe   785 QQECLLVHDNQAEVVVQNAYDVLIQLRKLESPLNKSPSREHTVYI----STSLEPLKYFYDAIEQ 845

  Fly   946 --------ASDLATISYCSNVVFDSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQ 1002
                    .|...||....|..|         ||:......:.|:.|.|..:.::  ||:|..|.
pombe   846 STNLKLKSISQEDTIDLMRNQTF---------ILSRISSDTILLVPKKLYPSKRK--KLRKNLDD 899

  Fly  1003 LVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEI 1042
            |.:.:.|:.....::.| .|.|:.::..|    ||.:.:|
pombe   900 LQKKLDKIQHTTSSSGY-EKAPSYIKLKN----CELQKDI 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	337/949 (36%)
vrs2	NP_593819.1	PTZ00419	18..945	CDD:240411	337/949 (36%)