DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and Vars

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_035820.3	Gene:	Vars / 22321	MGIID:	90675	Length:	1263	Species:	Mus musculus

Alignment Length:	1049	Identity:	630/1049 - (60%)
Similarity:	766/1049 - (73%)	Gaps:	26/1049 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAPGEKK 84
            |.||..||:||..|.|||.|.|.|  :|....|..||||.||||:.|.......|...|.|||||
Mouse   227 PQKTPAQLKKEAKKREKLEKFQQK--QKTQQQPPHGEKKPKPEKKEKRDPGVITYDLPTPPGEKK 289

  Fly    85 DLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHA 149
            |:|||:||:|||:||||.||.|||::|||.|||||.|:.||||.|.|:|.|||||||||||||||
Mouse   290 DVSGAMPDSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPNPRGVFMMCIPPPNVTGSLHLGHA 354

  Fly   150 LTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWR 214
            |||||:|::||:|||:|.||||.||||||||||||||||.||::..|:||.||||.|:|.:|.|:
Mouse   355 LTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWK 419

  Fly   215 REKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAI 279
            .|||.|||.|||.||||.||.|..|||||||...||||||||||||.||||:|||||||||.|||
Mouse   420 AEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAI 484

  Fly   280 SDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEG--SDEEIIVATTRIETMLGDTAVAVH 342
            |||||||.|:.|||.|.:|||::|||||||:.|||||:|  ||||::||||||||||||.|||||
Mouse   485 SDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVH 549

  Fly   343 PQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIF 407
            |:|.||:||.||.|||||.:|.||||.|:||||.|||||||||||||.||||||:|..|..|:|.
Mouse   550 PKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIM 614

  Fly   408 NDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYV 472
            :..|.:|.....|.|:.|||.||.:|..||...|:|...:||||||:|:|||||||||::|||||
Mouse   615 DSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYV 679

  Fly   473 SCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQT 537
            .|.:||.:|:.||..|:|:|:||.|.:||:.|||.|||||:|||||||||||||.::..||::..
Mouse   680 RCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHDPAVPP 744

  Fly   538 GSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWP 602
            |.      :.|.:||:..|:||||..|||..|||...||.|:|||||||||||||:||||:||||
Mouse   745 GE------DPDGRYWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWP 803

  Fly   603 DQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGN 667
            :|::||..|||.:|||||||||||||||||..|.||.|||||:|||||.:|||||||||||||||
Mouse   804 NQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGN 868

  Fly   668 VIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQAR 732
            ||||:|||.|::|:||:.||:.|||||.|:||||.|||.|:|.||||||:|||||.||||.:|.|
Mouse   869 VIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCAYTSQGR 933

  Fly   733 DINLDINRVLGYRFFCNKLWNATKFAL----LYFTGSEKFDTELSASAAINQMDAWILSRLAAAI 793
            |||||:||:||||.|||||||||||||    ..|..|.....|...|.    :|.||.|||..|:
Mouse   934 DINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSATSKPEGHESL----VDRWIRSRLTEAV 994

  Fly   794 EACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLL 858
            ...|.||::|||.|.|:|.|:||||:|||||||||||:.....:.....||:|||.|||.|||||
Mouse   995 RLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLL 1059

  Fly   859 SPFMPFITEELYQRLPRANP-AP-SICVASY--PSNTSWRSTKIESDVEFVQKAARIIRSARSDY 919
            ||||||:||||:|||||..| || |:||..|  ||..||:..:.|:.:|......|.:||.|:||
Mouse  1060 SPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADY 1124

  Fly   920 NLPNKVKTEVYIVCTDSVPSEI---LKRYASDLATISYCSNVVFDSPAPQGCAILTVTGQCEVHL 981
            || .:.:.:.::...|.....:   :..|...||:....:.:...:|||||||:...:.:|.:||
Mouse  1125 NL-TRTRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVAVASDRCSIHL 1188

  Fly   982 LLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERIA 1046
            .|:|||:..:|:.|||.|..:..:...:|.:...|:.|:.|||.|||||:|.||.::.||:.::.
Mouse  1189 QLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEAELRKVD 1253

  Fly  1047 AAIETLKLM 1055
            .||...:.|
Mouse  1254 EAIALFQKM 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	602/985 (61%)
		ValRS_core	129..736	CDD:185677	418/608 (69%)
		tRNA-synt_1_2	307..436	CDD:290334	86/130 (66%)
		Anticodon_Ia_Val	736..873	CDD:153416	81/140 (58%)
		Val_tRNA-synt_C	978..1053	CDD:287436	29/74 (39%)
Vars	NP_035820.3	GST_C_family	92..213	CDD:383119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..294		34/68 (50%)
		PTZ00419	281..1263	CDD:240411	604/993 (61%)
		'HIGH' region	343..353		9/9 (100%)
		'KMSKS' region	861..865		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835721
Domainoid	1	1.000	933	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4587
Inparanoid	1	1.050	1285	1.000	Inparanoid score	I164
Isobase	1	0.950	-	0	Normalized mean entropy	S561
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	1	1.000	-	-		oto92178
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	LDO	PTHR11946
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1458
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750