DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and vars-1

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_505070.3	Gene:	vars-1 / 179184	WormBaseID:	WBGene00006935	Length:	978	Species:	Caenorhabditis elegans

Alignment Length:	1014	Identity:	358/1014 - (35%)
Similarity:	522/1014 - (51%)	Gaps:	114/1014 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPN--PNGK-FVMIIPPPNVTGSLHLGHALTNAI 154
            ||||..:..:..|.:..:........|....|.|  .||. |.|::|||||||.||||||||.|:
Worm    18 AYSPTIITRESSSSFNIDEVTQNFEQRTEFAAANYRKNGSLFRMVLPPPNVTGKLHLGHALTVAV 82

  Fly   155 EDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGG 219
            ||||.|:.|.:|....|:||.|||||||||||||:|.::.| .|.::.||:|::....|..:...
Worm    83 EDAICRHQRNQGNKAEWIPGFDHAGIATQVVVEKILAKNGK-RRLEMTREEFVKECHLWGEKCSS 146

  Fly   220 RIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEV 284
            .|.:||..:|:|.|||:..:|:|.|...|||:||..|.:|..|.|..|||:|..||.|.:|..||
Worm   147 EIRQQLTRMGASLDWTQSYYTLDSKFSEAVTKAFCILEQEDLITRGKRLVHWCPTLSSTLSSQEV 211

  Fly   285 DKVEIPGRTFLSI---PGYEDKVEFGVLIKFAYKVEGSDEEII-VATTRIETMLGDTAVAVHPQD 345
            :::::|...::::   .|...:|:||.:....|.:..|:.|.| |.|||.||:..|.||||||:|
Worm   212 NRIDVPSDGYINLSSSSGTRRRVKFGQMHVIRYNLVDSESEFIEVGTTRPETLFADVAVAVHPED 276

  Fly   346 DRYKHLHGKFVVHPFST-RRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKR--CNLPFITI- 406
            |||...|||.|..|.:. |:|.::.|..|.:..|||||||||:||..|||:..|  .|....||
Worm   277 DRYSKFHGKHVWSPVTPGRKLFVITDSAVSVEKGTGAVKITPSHDALDYEIWNRWILNAGQNTIE 341

  Fly   407 ----FNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNP-MVVPICSRSKDVVEPLI 466
                .:.:|.:.....:|.||.|||.|:|:::||..|..|...:.:. ..|.||||:.|::||.:
Worm   342 EFACIDAEGKMTNSGEDFDGMDRFEAREKVIQKLSELGNYNGLMKHEGAQVNICSRTGDIIEPRL 406

  Fly   467 KPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFT 531
            ..||::.|.||.|.:.:|::||::::.||:.:.....|.:....||:|||||||||||||:|
Worm   407 TEQWFLDCKDMFARSADAIKSGKIEVFPEYQSHRLADWFENQEPWCLSRQLWWGHRIPAYNV--- 468

  Fly   532 DPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPF 596
                 .|.|.          |:|...|.||..:..::         ::||.|||||||||.:.|.
Worm   469 -----PGQSK----------WMVTTDEEEARRELGDK---------MQQDPDVLDTWFSSALVPL 509

  Fly   597 SVFGW----PDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKL-LGKLPFKEVYLHPMVRDA 656
            ...||    |.||..|      :::|||.||..||||||:....|| .|:.||.:|.||.:|||.
Worm   510 VKNGWLEGAPIQTPSL------NVMETGWDISGFWVARMIALNMKLSSGETPFGKVVLHGLVRDN 568

  Fly   657 HGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALR 721
            .||||||||||||||:||:.|||.|.:..::..|..:..||:.|.....:.:|.||..||.||||
Worm   569 EGRKMSKSLGNVIDPLDVLDGITFEKMIERVKSSAHEKEEIDNAVKDLTKRFPNGISRCGPDALR 633

  Fly   722 FALCAYITQARDINLDI-NRVLGYRFFCNKLWNATKFALLYFTGSEKFDT--ELSASAAINQMDA 783
            |||..|...:.||.:|: |..:....||||:||   .|..|...:||.:.  ::.:...:   |.
Worm   634 FALLKYDVLSTDIPIDVSNAAIEGLHFCNKIWN---LAAYYDQLAEKCEVIKDVDSDRLV---DE 692

  Fly   784 WILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLY 848
            ||::||:..:...:.....:....|.|..:.|...|:||:|||..|....:....:...||..|.
Worm   693 WIMARLSTTVSTVDAHMNKFSLHLALSTLHKFITSDICDIYLESTKKALWNNDIARIREARSILQ 757

  Fly   849 VCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPSNTSW-RSTKIESDVEFVQKAARII 912
            ..|...|..|:.||||::|.:|:|:.:......:.....||...: |:.::|..::.:......|
Worm   758 RVLQPTLVQLNAFMPFVSEYIYERIFKRETGSILFDVVKPSLFIFHRNEELEEAMKLITAMMAAI 822

  Fly   913 RSARSDYNLPNKVKTE--VYIVCTDSVPSEILKRYASDLATIS-------YCSNVVFD------- 961
            ||.|....||.::...  :.:..||:.|||:  |..:|..|.:       .|..|..|
Worm   823 RSTRQTLQLPQRITFSGILEMAPTDTSPSEL--RILADEVTQTCGFELQKVCREVDEDIKKDHMA 885

  Fly   962 SPAPQGCAIL--TVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTV--------------GKL 1010
            .|.|...|.|  .:...|:...:|    ...:::.|.:.:.:|....:              ..:
Worm   886 CPVPGHDAKLWMRIDADCKEMFIL----SLKRQLEKTKTRQEQFQARIASYEAICENPNSKPSNV 946

  Fly  1011 TQAIQAADYATKVPAEVQEANETKLCESRAEIERIAAAI 1049
            |:..:.|:.|.||   |:.|.|        |.|||...|
Worm   947 TKTKRKAENARKV---VENAKE--------EAERIKQLI 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	358/1014 (35%)
		ValRS_core	129..736	CDD:185677	267/625 (43%)
		tRNA-synt_1_2	307..436	CDD:290334	58/137 (42%)
		Anticodon_Ia_Val	736..873	CDD:153416	39/139 (28%)
		Val_tRNA-synt_C	978..1053	CDD:287436	16/86 (19%)
vars-1	NP_505070.3	PTZ00419	54..971	CDD:240411	348/973 (36%)
		nt_trans	59..648	CDD:294020	266/622 (43%)
		tRNA-synt_1_2	242..375	CDD:290334	57/132 (43%)
		Anticodon_Ia_Val	656..782	CDD:153416	37/131 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780