DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and glp-4

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_493377.1	Gene:	glp-4 / 173224	WormBaseID:	WBGene00006936	Length:	1050	Species:	Caenorhabditis elegans

Alignment Length:	1054	Identity:	574/1054 - (54%)
Similarity:	725/1054 - (68%)	Gaps:	26/1054 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GDPPKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKE-VKEAAVYTAQTAPG 81
            |:.|||.|:|:||..||.||||.:.|..|.|....||.:|..|..|..|| ..|||....||..|
Worm     6 GNRPKTEKELKKEAEKAAKLAKFEEKQKKLAEKKAAASDKPVKEAKAKKEQTVEAAEPVDQTPTG 70

  Fly    82 EKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHL 146
            ::|.:.|.:|.||.|.|||:.|||||||||||.|||........||...|.:.||||||||:||:
Worm    71 QRKKIDGEIPAAYFPGYVESGWYSWWEKEGFFKPEYIDKLNPGSNPADSFTVCIPPPNVTGNLHV 135

  Fly   147 GHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIW 211
            ||||...:||.|||::||.|:.||:.||||||||||||||||.|.|:..|:||||||::|.:.:|
Worm   136 GHALATTVEDTITRFNRMHGKRTLFNPGCDHAGIATQVVVEKRLKRERGLTRHDLGRDRFNQEVW 200

  Fly   212 DWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLR 276
            .|:.|||..||:|.:.||:|.||.|..||||||:||||||||:|:||.|:||||:|||||||.||
Worm   201 HWKNEKGDVIYDQFRKLGASVDWDRAVFTMDPKMCRAVTEAFIRMHESGTIYRSNRLVNWSCALR 265

  Fly   277 SAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAV 341
            ||||||||||.|:.|.|.:::|||:.|:|||||..||||::||||||:|:||||||||||:.|||
Worm   266 SAISDIEVDKKELTGSTLIAVPGYDKKIEFGVLNSFAYKIQGSDEEIVVSTTRIETMLGDSGVAV 330

  Fly   342 HPQDDRYKHLHGKFVVHPF-STRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFIT 405
            ||.|.|||||.||..:||| .||.|||..|.||:|.|||||||||||||.||||||.|.||||..
Worm   331 HPDDQRYKHLVGKQCIHPFIPTRNLPIFADSFVEMEFGTGAVKITPAHDHNDYEVGIRQNLPFHN 395

  Fly   406 IFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQW 470
            ...|||.|....|||:|||||:.|..::|.||...|||...:||||||.|||||||:||::||||
Worm   396 CITDDGLISQGCGEFSGMKRFDARTAVIEALKEKGLYRGKEDNPMVVPTCSRSKDVIEPILKPQW 460

  Fly   471 YVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSL 535
            ||.|:.||..|..||.:|:|:||||.|..||..|::..||||:|||||||||||||::||.|...
Worm   461 YVKCAHMAEKAVAAVANGDLQIIPEFHKATWNRWLESSRDWCISRQLWWGHRIPAYYISFADGRE 525

  Fly   536 QTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFG 600
            |.        ..:|.||:.||:|.|||.|||::|.|..::|:||.||||||||||||::||:|||
Worm   526 QP--------LPEENYWVSARTEQEALAKAAQKFQVPEAEILLKWDEDVLDTWFSSGMWPFAVFG 582

  Fly   601 WPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSL 665
            |||.|||:..|:|.::|||||||||||||||||..|:|.|||||||:.||.|:||||||||||||
Worm   583 WPDATKDMDLFFPGAVLETGHDILFFWVARMVFMAQELTGKLPFKEILLHAMIRDAHGRKMSKSL 647

  Fly   666 GNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQ 730
            ||||||:||||||:|..|.|||:|.|||.:||..||.||.:|||.||||||.|||||||.:|.:|
Worm   648 GNVIDPLDVIRGISLNDLQAQLLGGNLDEKEIAVAKEGQARDYPDGIPECGVDALRFALLSYTSQ 712

  Fly   731 ARDINLDINRVLGYRFFCNKLWNATKFALLYFTG--SEKFDTELSASAAINQMDAWILSRLAAAI 793
            .||||||:.||.|||.||||||...:|||...:.  .:|...|::..:| ...|.|||||||.|:
Worm   713 GRDINLDVLRVHGYRKFCNKLWQVVRFALARISDKPEQKPTFEINLKSA-TPTDLWILSRLAKAV 776

  Fly   794 EACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLL 858
            :..|...::|:|..||:..|.|||||.||||:|.:||:....:...:..|...|:.|:|.||||:
Worm   777 KETNEALKAYNFTQATTVTYNFWLYDFCDVYVETIKPVLYGDNTTLRQVAISVLHKCIDTGLRLI 841

  Fly   859 SPFMPFITEELYQRLPRAN----PAPSICVASYP---SNTSWRSTKIESDVEFVQKAARIIRSAR 916
            ||.||||:|||:||:||.:    .:|||.||.||   ....:::.|:|:..||.|:....:||.|
Worm   842 SPLMPFISEELWQRMPRLDDSDYTSPSIIVAQYPLTQKYEKYQNEKLEAAFEFAQELIGKVRSLR 906

  Fly   917 SDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVF-----DSPAPQGCAILTVTGQ 976
            :||:| .|.|..:.|:........:|...::.:.|:::...|..     .....:|.|.:...|:
Worm   907 ADYDL-KKTKITMQILSETPEDESMLNDISAVITTLTFSEKVSILNKCESDKIEKGSAHIACGGR 970

  Fly   977 CEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAE 1041
            |:|::.|.|:::..|||.||..|..:...:|.|:.....:|||..|||.:::..::.|......|
Worm   971 CQVYINLTGIIDVPKEIEKLGAKLQKNQISVKKIGDIQSSADYEQKVPVDIRALDQEKKATLEKE 1035

  Fly  1042 IERIAAAIETLKLM 1055
            ||.|.|||..||.:
Worm  1036 IENITAAIAQLKAL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	543/987 (55%)
		ValRS_core	129..736	CDD:185677	396/607 (65%)
		tRNA-synt_1_2	307..436	CDD:290334	87/129 (67%)
		Anticodon_Ia_Val	736..873	CDD:153416	64/138 (46%)
		Val_tRNA-synt_C	978..1053	CDD:287436	25/74 (34%)
glp-4	NP_493377.1	PTZ00419	51..1050	CDD:240411	553/1009 (55%)
		ValRS_core	118..718	CDD:185677	396/607 (65%)
		tRNA-synt_1_2	301..426	CDD:290334	84/124 (68%)
		Anticodon_Ia_Val	718..856	CDD:153416	64/138 (46%)
		Val_tRNA-synt_C	982..1047	CDD:287436	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166790
Domainoid	1	1.000	879	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4587
Inparanoid	1	1.050	1126	1.000	Inparanoid score	I112
Isobase	1	0.950	-	0	Normalized mean entropy	S561
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	1	1.000	-	-		oto19886
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	LDO	PTHR11946
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1458
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750