DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and vars2

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	XP_002940996.3	Gene:	vars2 / 100493727	XenbaseID:	XB-GENE-6046089	Length:	1033	Species:	Xenopus tropicalis

Alignment Length:	1053	Identity:	515/1053 - (48%)
Similarity:	676/1053 - (64%)	Gaps:	71/1053 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KERL-KAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAV--YTAQTAPGEKKDLSGAL 90
            :||. :||:..:.|..||:.|         ::.|..:.:..||..|  |.|.|.||:|||:|..|
Frog    25 RERARRAERQQRKQNLLDEVA---------EQVPHVKGQNWKEKIVLEYEAVTEPGKKKDISVPL 80

  Fly    91 PDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIE 155
            |.:||||||||.||.||.::|||.|||  .|....|.:..:.:.|||||||||||:|||||.|||
Frog    81 PHSYSPRYVEAAWYPWWVRQGFFKPEY--QSQQPHNGSETYSLCIPPPNVTGSLHIGHALTVAIE 143

  Fly   156 DAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGR 220
            |::.|:.||.|...|||||.||||||||.||||.|.:::.|.|||..||:|::.:|.|:.|||..
Frog   144 DSLVRWKRMLGHKVLWVPGSDHAGIATQAVVEKKLLKEKGLLRHDFSREEFLKEVWKWKEEKGDI 208

  Fly   221 IYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVD 285
            ||.||:|||:|.||.|..||||....|||:|||||||.:|.:||..|||||||.|||||||||||
Frog   209 IYHQLRSLGASLDWDRCCFTMDKMFSRAVSEAFVRLHNDGLVYRHLRLVNWSCALRSAISDIEVD 273

  Fly   286 KVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAVHPQDDRYKH 350
            ..::.|:|::|:||||.|:.||:|..|||..||.|:||||:|||.|||||||||||||.|.||..
Frog   274 SRQLTGKTYISVPGYERKIPFGLLFSFAYVTEGGDDEIIVSTTRPETMLGDTAVAVHPNDPRYLR 338

  Fly   351 LHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIG 415
            .||..:.|||:.:.:|:|..:||:..|||||||:||||...|:|:.:..:||.:::..:||.:..
Frog   339 FHGTRLHHPFTGQLIPVVTHDFVNPDFGTGAVKVTPAHSLADFEMAQSLDLPVVSVIGEDGLMTE 403

  Fly   416 DYGEF-TGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAA 479
            :.||: .|:|||:.|::||..||...|||....:.||:|:||||.||:|.|:|.||:|||..||.
Frog   404 NSGEWIQGVKRFDAREQILSALKEKGLYRGDYEHAMVLPVCSRSGDVIEQLLKRQWFVSCKKMAQ 468

  Fly   480 SATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGS 544
            .|.|||..|:|||||..|.|.|.||:..|.||||||||||||:||||||:.::      :.:...
Frog   469 KALEAVNVGQLKIIPSFHQKNWNHWLSNISDWCVSRQLWWGHQIPAYHVAVSE------AQSDKD 527

  Fly   545 VNDD-EQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDL 608
            :.|: |:.|:||.:|:||..||:::.......:.:|:|||||||||||.:|||::.|||:.|.||
Frog   528 IRDEQEEIWVVAHNESEAKKKASKKLRRPEKDLSVKRDEDVLDTWFSSALFPFAMLGWPENTSDL 592

  Fly   609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMD 673
            :.|||.||||||.|:|||||||||..|:.|.||||||||:||.||||||||||||||||||||:|
Frog   593 KDFYPNSLLETGSDLLFFWVARMVMLGEHLTGKLPFKEVFLHSMVRDAHGRKMSKSLGNVIDPLD 657

  Fly   674 VIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDI 738
            ||.||:||.|..:|...||||||::.|:||..:.:|:||||||:||||||||:|..|..|||||:
Frog   658 VITGISLEELQNRLQDGNLDPRELKVAEAGLLKAFPRGIPECGTDALRFALCSYKVQGDDINLDV 722

  Fly   739 NRVLGYRFFCNKLWNATKFALLYFTGS------EKFDTELSASAAINQMDAWILSRLAAAIEACN 797
            ..||..|.||||:||..||.|.....|      |:|..:       ..||.|:|..|....|.|.
Frog   723 PSVLAVRHFCNKIWNGIKFTLSSLGESFSPIPVEEFKPQ-------GPMDRWLLDHLRLLTEECE 780

  Fly   798 TGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQS--GSEEQQTAARRTLYVCLDYGLRLLSP 860
            ..|::|:...||.|...||:...||.|:|.:|||.:.  ||:.||     |||...:..||||:|
Frog   781 RRFQAYELHGATGAIQTFWVQSYCDFYVEAVKPILKGPHGSDAQQ-----TLYWGAEIVLRLLAP 840

  Fly   861 FMPFITEELYQRLPRA--NPAPSICVASYPSNTS---WRSTKIESDVEFVQKAARIIRSARSDYN 920
            |.||:.|||:||.|.|  |.|||||||.||:.:.   ||..:.....:|||...|.:||.||||:
Frog   841 FTPFLCEELWQRFPSASVNCAPSICVAQYPTPSQMAHWRYPEEVQQFDFVQSVIRTVRSLRSDYH 905

  Fly   921 LPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCS----NVVFDSPA----PQGCAILTVTGQC 977
            : .|.:.||:|.|:.......|:.:.|.|.|:|:..    :::.|:..    |.|.|...|:..|
Frog   906 M-TKARPEVHIFCSMEEHLNALQSFHSHLPTLSHSGPIQVHMLQDASQFREDPVGWATEKVSEGC 969

  Fly   978 EVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEI 1042
            .:.:.|:||::...|:|||.||...|      ..|.|..:.|.       ...||.|..:.:  |
Frog   970 YLRVKLQGLLDPHTELAKLHKKHQNL------QLQFINMSKYE-------NGDNEDKSIQQK--I 1019

  Fly  1043 ERIAAAIETLKLM 1055
            .::...:|||:.|
Frog  1020 SKVQCTMETLQRM 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	498/995 (50%)
		ValRS_core	129..736	CDD:185677	352/608 (58%)
		tRNA-synt_1_2	307..436	CDD:290334	66/129 (51%)
		Anticodon_Ia_Val	736..873	CDD:153416	57/144 (40%)
		Val_tRNA-synt_C	978..1053	CDD:287436	19/74 (26%)
vars2	XP_002940996.3	PTZ00419	57..1033	CDD:240411	506/1012 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11946
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110