DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and vars1

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	XP_002939512.3	Gene:	vars1 / 100489760	XenbaseID:	XB-GENE-487344	Length:	1243	Species:	Xenopus tropicalis

Alignment Length:	1054	Identity:	634/1054 - (60%)
Similarity:	770/1054 - (73%)	Gaps:	18/1054 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ANAPAGAGGD-PPKTAKQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAV 73
            ::.|:|...: |||||.||:||..|.|||.:.|.|.:|   .....||||.||||:.|:......
Frog   199 SDGPSGTPSNAPPKTAAQLKKESKKKEKLERFQQKQEK---IKELQGEKKPKPEKKDKKELGVIT 260

  Fly    74 YTAQTAPGEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPP 138
            |...|..|:|||:||.:||:|||:|||:.||||||||.||.||:||:||..|||.|.|:|.||||
Frog   261 YDIPTPAGDKKDVSGPMPDSYSPQYVESAWYSWWEKEKFFKPEFGRSSISEPNPKGLFMMCIPPP 325

  Fly   139 NVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGR 203
            ||||||||||||||||:|.:||:|||:|..|||.||||||||||||||||.|||:...:|||.||
Frog   326 NVTGSLHLGHALTNAIQDCLTRWHRMRGELTLWNPGCDHAGIATQVVVEKKLWRERGKTRHDFGR 390

  Fly   204 EKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRL 268
            |.|||.:|.|:||||.|||.||:.||||.||.|..|||||||..||.|||:||||.|.||||.||
Frog   391 ENFIEEVWKWKREKGDRIYHQLRILGSSLDWDRTCFTMDPKLSFAVQEAFIRLHEAGIIYRSKRL 455

  Fly   269 VNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETM 333
            |||||||.||||||||||.|:.|||.|.:|||:..||||||:.|||||:.:.|||:|||||:|||
Frog   456 VNWSCTLNSAISDIEVDKKELSGRTLLPVPGYKQGVEFGVLVSFAYKVQETGEEIVVATTRVETM 520

  Fly   334 LGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKR 398
            ||||||||||||.|||||.|..|:|||.:|.||||.||||||:||||||||||||||.|||||.|
Frog   521 LGDTAVAVHPQDQRYKHLKGHHVLHPFCSRLLPIVFDEFVDMSFGTGAVKITPAHDPTDYEVGMR 585

  Fly   399 CNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVE 463
            .:|.|:.|.:|:|.:|.....|.|||||:.||.:|:.||...|::|..:||||||:||||||:||
Frog   586 HSLDFVNIMDDNGTLINVPQPFLGMKRFDARKAVLDALKEKGLFKEVKDNPMVVPVCSRSKDIVE 650

  Fly   464 PLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHV 528
            ||:||||||.|.:|...|.:|||.|.|.|.||.|||||:.|||.|||||:|||||||||||||.|
Frog   651 PLLKPQWYVRCDEMGKRAADAVRDGHLLIKPEFHTKTWFIWMDNIRDWCISRQLWWGHRIPAYFV 715

  Fly   529 SFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGI 593
            :..|||:..|....|      :|||..|||.||..|||..|.|...||.|:||:|||||||||||
Frog   716 TVNDPSVPAGEDTDG------KYWISGRSEQEAKEKAARVFNVAPEKISLRQDDDVLDTWFSSGI 774

  Fly   594 FPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHG 658
            ||||:||||:||:||..|||.:|||||||||||||||||..|..|.|||||||||||.:||||||
Frog   775 FPFSIFGWPNQTEDLNVFYPGTLLETGHDILFFWVARMVMLGLTLTGKLPFKEVYLHAVVRDAHG 839

  Fly   659 RKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFA 723
            |||||||||||||:|||.|||||||:.||:.|||||.|:|:||.|||.|||.||||||:||||||
Frog   840 RKMSKSLGNVIDPLDVINGITLEGLNKQLLESNLDPAELERAKDGQKSDYPNGIPECGTDALRFA 904

  Fly   724 LCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQMDAWILSR 788
            ||||.:|.||||||:||:||||.||||:|||||||:.....:........|....:..|.|||||
Frog   905 LCAYTSQGRDINLDVNRILGYRHFCNKIWNATKFAMKGLGDNYSPPDFAGACGQESLADRWILSR 969

  Fly   789 LAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDY 853
            |:.|::.||.||::|||...|:|.|.||||:|||||||||||:|.|..|...:..|.|||.|||.
Frog   970 LSFAVDLCNNGFQNYDFPGITTAVYNFWLYELCDVYLECLKPVFLSSDEAAISVGRNTLYTCLDA 1034

  Fly   854 GLRLLSPFMPFITEELYQRLPR--ANPAPSICVASYP--SNTSWRSTKIESDVEFVQKAARIIRS 914
            |||||||||||:||||||||||  ::..|||.|.|||  |..:||..:||.:::......:.|||
Frog  1035 GLRLLSPFMPFLTEELYQRLPRRSSSRTPSISVTSYPETSECNWRDEEIERNMDLALLIVKSIRS 1099

  Fly   915 ARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVV---FDSPAPQGCAILTVTGQ 976
            .|:|||| .|.|.:.::.|.|:....::..|.|.:..:|...::|   ...|||.|.|:.|.:.:
Frog  1100 LRADYNL-TKTKADCFVQCQDADTVSVVTAYTSFITVLSSSRSLVTLKAQDPAPAGSAVNTASDK 1163

  Fly   977 CEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAE 1041
            ..|:::||||::.:||:||||.|..:|.:.:.||.:.:.:|||.:|||..||:.:..::.::..|
Frog  1164 ATVYVVLKGLIDVEKELAKLQVKKTELGRQLEKLRERMGSADYRSKVPETVQQQDAERIRQTETE 1228

  Fly  1042 IERIAAAIETLKLM 1055
            .:::..|.|..:.|
Frog  1229 FKKVNEAAENFQKM 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	604/979 (62%)
		ValRS_core	129..736	CDD:185677	426/606 (70%)
		tRNA-synt_1_2	307..436	CDD:290334	87/128 (68%)
		Anticodon_Ia_Val	736..873	CDD:153416	80/136 (59%)
		Val_tRNA-synt_C	978..1053	CDD:287436	26/74 (35%)
vars1	XP_002939512.3	GST_C_family	79..192	CDD:413470
vars1	XP_002939512.3	PTZ00419	263..1242	CDD:240411	605/985 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	942	1.000	Domainoid score	I42
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4587
Inparanoid	1	1.050	1295	1.000	Inparanoid score	I162
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	1	1.000	-	-		oto102491
Panther	1	1.100	-	-	LDO	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080