DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS and vars2

DIOPT Version :9

Sequence 1:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_001124133.1	Gene:	vars2 / 100170827	ZFINID:	ZDB-GENE-060503-575	Length:	1057	Species:	Danio rerio

Alignment Length:	1052	Identity:	506/1052 - (48%)
Similarity:	677/1052 - (64%)	Gaps:	49/1052 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KQLEKERLKAEKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAPGEKKDLSGA 89
            :.|...|.:|||..:.||:  :||..:....:     :..:...||...|.|:.:||||||.:..
Zfish    29 QSLSHPRTQAEKAKRRQAR--EKAILSSDLND-----DGLSWSDKEKIKYAAKLSPGEKKDTTLP 86

  Fly    90 LPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAI 154
            .|.:|||.|||..||.||||:|||:||.......|.:.:  |.:.||||||||:||||||||.||
Zfish    87 FPQSYSPEYVEFGWYQWWEKQGFFSPEQHSKQPHAVDKH--FSLCIPPPNVTGTLHLGHALTVAI 149

  Fly   155 EDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGG 219
            |||:.|:.||:|...||||||||||||||.|||:.|.|::..||.|..||:|::::|.|:.|||.
Zfish   150 EDALARWRRMQGYKVLWVPGCDHAGIATQSVVERKLLREQGKSRQDFSREEFLKQVWMWKNEKGD 214

  Fly   220 RIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEV 284
            .||.||:.||:|.||:|..|||||....|||||||||.:.|.|||:..|:||||||.||||||||
Zfish   215 EIYHQLRKLGASLDWSRACFTMDPAFSSAVTEAFVRLCDSGLIYRAEGLINWSCTLESAISDIEV 279

  Fly   285 DKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAVHPQDDRYK 349
            |..|:||||.||:|||:.|||||.::.|||.:||.:.|:.|:|||.||||||.|:||||.|.|||
Zfish   280 DSKELPGRTLLSVPGYQQKVEFGTMVTFAYPLEGQEGEVAVSTTRPETMLGDVAIAVHPDDPRYK 344

  Fly   350 HLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYII 414
            |||||...|||:.:.||||.|..|||.|||||||:|||||..|:.:.::.:||.:|:...:|.:.
Zfish   345 HLHGKRCRHPFTEQLLPIVTDTTVDMTFGTGAVKLTPAHDHTDFLLSQKHSLPRLTVIGGNGTMT 409

  Fly   415 GDYGEF-TGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMA 478
            ...|:: .|:|||:.|::::..|....|:|...::||.:||||||.||:|||:|.||:|.|.:||
Zfish   410 SVCGQWLEGVKRFDARERVISALMERKLFRGKKDHPMSLPICSRSGDVIEPLLKKQWFVRCQEMA 474

  Fly   479 ASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHG 543
            ..|.:||..|:|:|||:.::|.|..|:..|.||||||||||||:||||.|:.           ..
Zfish   475 KKAVQAVEEGDLQIIPQFYSKMWKSWLSNISDWCVSRQLWWGHQIPAYRVTL-----------QN 528

  Fly   544 SVNDDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDL 608
            |:|.:|::|:..||.|||..:|..:|||:...|.|.||.||||||||||:|||::.|||.|||||
Zfish   529 SMNTEEEHWVWGRSAAEAQQRATIKFGVNPEAITLTQDPDVLDTWFSSGLFPFAMLGWPQQTKDL 593

  Fly   609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMD 673
            ..|||.|:||||.|::||||||||..|.:|.|:||||:|..|.:|||.:||||||||||||||:|
Zfish   594 TQFYPNSILETGSDLIFFWVARMVMLGTELTGQLPFKQVLFHSLVRDKYGRKMSKSLGNVIDPLD 658

  Fly   674 VIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDI 738
            ||.|::||.|..::...||||||...|...||:|:|:||||||:||||||||:|..|..||:|.:
Zfish   659 VISGVSLERLQEKVKEGNLDPRESIVAIEAQKKDFPKGIPECGTDALRFALCSYRAQGEDISLSM 723

  Fly   739 NRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESY 803
            :.||..|.||||:|...:|.|.....: ...|.|:.:..::.||.||.|||.:.::.|..|||||
Zfish   724 SHVLSCRHFCNKMWQTVRFTLATLNDA-SLPTPLAETYPLSSMDKWICSRLYSTVKECEQGFESY 787

  Fly   804 DFAAATSACYAFWLYDLCDVYLECLKPIFQ-SGSEE---QQTAARRTLYVCLDYGLRLLSPFMPF 864
            :....|||.::|||:.|||||||.:||:.: .|.||   ::..|...||..:...|.||||||||
Zfish   788 ELYTVTSALHSFWLHCLCDVYLESIKPLLKPEGCEERVGERQVATSVLYHSVSVSLALLSPFMPF 852

  Fly   865 ITEELYQR-LPRAN---PAPSICVASYPSNTS---WRSTKIESDVEFVQKAARIIRSARSDYNLP 922
            :||||:|| ||..:   .:.|:||..||..:.   |...|.|:|...||:..|:.|..|:...:
Zfish   853 LTEELWQRLLPYGHFDKTSCSLCVQPYPKTSQLEHWYFPKEEADFSLVQEVVRVTRLLRAQCQM- 916

  Fly   923 NKVKTEVYIVCTDSVPSEILKRYASDLATIS-------YCSNVVF-DSPAPQGCAILTVTGQCEV 979
            .|.|.::|.||... ..|||.|:.|.:.|:.       :|....| |.|:.:..|:..|.....:
Zfish   917 TKEKPDLYAVCAPD-QMEILLRFRSAICTLGRISTLHLHCPEAGFSDCPSAKASAVGVVDHSLCL 980

  Fly   980 HLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAI---QAADYATKVPAEVQEANETKLCESRAE 1041
            ||..:..|.|||:.|.|.::.::|   ..||.||:   |...|..|||.:|::..|.|:.....|
Zfish   981 HLSAQNGVNADKQRAILCQRREKL---AFKLKQALARTQTHSYIEKVPQKVRQEMENKITAMEQE 1042

  Fly  1042 IERIAAAIETLK 1053
            ::.|...:..||
Zfish  1043 MKNIEDQLLALK 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	491/995 (49%)
		ValRS_core	129..736	CDD:185677	348/607 (57%)
		tRNA-synt_1_2	307..436	CDD:290334	65/129 (50%)
		Anticodon_Ia_Val	736..873	CDD:153416	62/141 (44%)
		Val_tRNA-synt_C	978..1053	CDD:287436	23/77 (30%)
vars2	NP_001124133.1	PTZ00419	66..1054	CDD:240411	495/1006 (49%)
		ValRS_core	124..721	CDD:185677	348/609 (57%)
		tRNA-synt_1_2	302..>402	CDD:290334	58/99 (59%)
		Anticodon_Ia_Val	721..861	CDD:153416	61/140 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830