DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha1 and SCL1

DIOPT Version :9

Sequence 1:	NP_524837.2	Gene:	Prosalpha1 / 45780	FlyBaseID:	FBgn0263121	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_011504.3	Gene:	SCL1 / 852873	SGDID:	S000002979	Length:	252	Species:	Saccharomyces cerevisiae

Alignment Length:	247	Identity:	121/247 - (48%)
Similarity:	167/247 - (67%)	Gaps:	9/247 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSAGFDRHITIFSPEGRLYQVEYAFKAIAQENITTVALKSGDCAVVATQKKVTEKNIVPETVTHL 69
            |:||:||||||||||||||||||||||..|.||.::|::..||.||.:||||.:|.:.|.||:::
Yeast     8 SAAGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDKLLDPTTVSYI 72

  Fly    70 FRITKDIGCAMTGRIADSRSQVQKARYEAANFRYKYGYEMPVDVLCRRIADINQVYTQNAEMRPL 134
            |.|::.||..:.|.|.|:|:...:|:.|||.|||||||:||.|||.:|:|:::|:|||.|.||||
Yeast    73 FCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPL 137

  Fly   135 GCSMVLIAYDNEIGPSVYKTDPAGYFSGFKACSVGAKTLEANSYLEKKYKPNL-------SEEKA 192
            |..:..::.|.|:|||:||||||||:.|:||.:.|.|..|..:.||..:|.:.       |.||.
Yeast   138 GVILTFVSVDEELGPSIYKTDPAGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKV 202

  Fly   193 IQLAISCLSSVLAIDFKPNGIEIGVVSKSDPTFRILDEREIEEHLTKIAEKD 244
            ::.||:.:...|..:|..|.:|:||.:|.  .|..|....|||.|..|||:|
Yeast   203 VEFAITHMIDALGTEFSKNDLEVGVATKD--KFFTLSAENIEERLVAIAEQD 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha1	NP_524837.2	PRE1	7..243	CDD:223711	118/242 (49%)
Prosalpha1	NP_524837.2	proteasome_alpha_type_6	8..218	CDD:239723	107/216 (50%)
SCL1	NP_011504.3	proteasome_alpha_type_6	12..228	CDD:239723	106/215 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346444
Domainoid	1	1.000	170	1.000	Domainoid score	I781
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2085
Inparanoid	1	1.050	238	1.000	Inparanoid score	I697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53623
OrthoFinder	1	1.000	-	-		FOG0002933
OrthoInspector	1	1.000	-	-		oto99999
orthoMCL	1	0.900	-	-		OOG6_102240
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1008
SonicParanoid	1	1.000	-	-		X1933
TreeFam	1	0.960	-	-
	15	14.790