DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha1 and PSMB8

DIOPT Version :9

Sequence 1:	NP_524837.2	Gene:	Prosalpha1 / 45780	FlyBaseID:	FBgn0263121	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_683720.2	Gene:	PSMB8 / 5696	HGNCID:	9545	Length:	276	Species:	Homo sapiens

Alignment Length:	196	Identity:	42/196 - (21%)
Similarity:	76/196 - (38%)	Gaps:	16/196 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RLYQVEYAFKAIAQENITTVALKSGDCAVVATQKKVTEKNIVPE-TVTHLFRITKDIGCAMTGRI 84
            |..|:|.|      ...||:|.|.....:.|...:.:..:.:.. .|..:..|...:...|:|..
Human    63 RNVQIEMA------HGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCA 121

  Fly    85 ADSRSQVQKARYEAANFRYKYGYEMPVDVLCRRIADINQVYTQNAEMRPLGCSM--VLIAYDNEI 147
            ||.:...:....|...:..:.|..:.|....:.::::...|      |.:|.||  ::..:|.:
Human   122 ADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQY------RGMGLSMGSMICGWDKK- 179

  Fly   148 GPSVYKTDPAGYFSGFKACSVGAKTLEANSYLEKKYKPNLSEEKAIQLAISCLSSVLAIDFKPNG 212
            ||.:|..|..|........|.|:....|...::..|:||||.|:|..|....::.....|....|
Human   180 GPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGG 244

  Fly   213 I 213
            :
Human   245 V 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha1	NP_524837.2	PRE1	7..243	CDD:223711	42/196 (21%)
Prosalpha1	NP_524837.2	proteasome_alpha_type_6	8..218	CDD:239723	42/196 (21%)
PSMB8	NP_683720.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
PSMB8	NP_683720.2	proteasome_beta_type_5	73..260	CDD:239730	38/180 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810