DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and TRIM56

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_112223.1	Gene:	TRIM56 / 81844	HGNCID:	19028	Length:	755	Species:	Homo sapiens

Alignment Length:	1109	Identity:	213/1109 - (19%)
Similarity:	342/1109 - (30%)	Gaps:	399/1109 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 SNGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSK 191
            |:|||..|          ||...|..:      .||:|..:|..|:.|.|||.:|:|||..:.
Human     3 SHGSSPSL----------LEALSSDFL------ACKICLEQLRAPKTLPCLHTYCQDCLAQLA-- 49

  Fly   192 DTMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDL---- 252
                            ||..         :.||.|::..|:.|:|:.:...::.|..:|||
Human    50 ----------------DGGR---------VRCPECRETVPVPPEGVASFKTNFFVNGLLDLVKAR 89

  Fly   253 --SNLESEHIVCTSC------KSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLT- 308
              .:|.:....|..|      .:...|.:||.|||:.||..|.:.|   ||....|..|:.||.
Human    90 ACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGH---RCTRQTHTHRVVDLVG 151

  Fly   309 -------KNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQ 366
                   :...::    :...||||..|.|::.|..|....|.:|.|..|  .||.......|.:
Human   152 YRAGWYDEEARER----QAAQCPQHPGEALRFLCQPCSQLLCRECRLDPH--LDHPCLPLAEAVR 210

  Fly   367 AVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLN 431
            |.|..||..|:...........|......||..|:.|...|..|:|:|.:...|.|.:.|.::|.
Human   211 ARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLG 275

  Fly   432 ELGRLHSD-RELKIMDLMQSMENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQT 495
            :| |.|.: .|....:.:..:|......:.||.|.:|.:......|.|.|:..| ||.|..::..
Human   276 QL-RAHVEAAEEAARERLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAI-AQRLRQLQGC 338

  Fly   496 P------KCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQ 554
            |      .|.:.   |.:..|.:.::....:...|:.........|.|...|..::.|.::: .:
Human   339 PWAPGPAPCLLP---QLELHPGLLDKNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRRE-DE 399

  Fly   555 QQHQHQHQVQQQQ-HHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHNSNNLIVG---HRGSSSVQ 615
            .:.:.|..||.|. ...|..:::|.|...::..|.|: :.:.|..|...    |   |||
Human   400 PKTERQGGVQPQAGDGAQTPKEEKAQTTREEGAQTLE-EDRAQTPHEDG----GPQPHRG----- 454

  Fly   616 GRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQ 680
            ||           |:. :..|.|...|:       ...|.|:....|..:
Human   455 GR-----------PNK-KKKFKGRLKSI-------SREPSPALGPNLDGS--------------- 485

  Fly   681 AVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPN 745
                                    .:|.:|....|.|.::                     ||..
Human   486 ------------------------GLLPRPIFYCSFPTRM---------------------PGDK 505

  Fly   746 IS--INGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDAL---AVGGGAAGPVPNVVAQVPGG 805
            .|  |.||...||....                :.|..|.||   ::.|...|.||     ||.|
Human   506 RSPRITGLCPFGPREIL----------------VADEQNRALKRFSLNGDYKGTVP-----VPEG 549

  Fly   806 SAVTGAAVVGASHAHQQQSQAVMPASA----VTPTQPITLADILSGDQRALNNLQALAKLGLNNN 866
            .:....|.:        ||.....|||    :.|...:..       :|||:..||
Human   550 CSPCSVAAL--------QSAVAFSASARLYLINPNGEVQW-------RRALSLSQA--------- 590

  Fly   867 DFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGTTSVVTGRNKATPMQIRCKFGSLGTAKG 931
                                         .|||||
Human   591 -----------------------------SHAVAA------------------------------ 596

  Fly   932 QFNSPHGFCLGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFV 996
               .|.|       :.:......| :||::..|:|..:|...||
Human   597 ---LPSG-------DRVAVSVAGH-VEVYNMEGSLATRFIPGGK--------------------- 629

  Fly   997 VCDRGNERSRMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRW 1061
                                    |.|.:..:..|..:.:||.|..|                 |
Human   630 ------------------------ASRGLRALVFLTTSPQGHFVGSD-----------------W 653

  Fly  1062 FDCSDYMREPSDIAIRDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCFPNGIDISNAGDVLI 1126
                           :.|...:||..|..|..::..|..         .|.|..:.:...|.:.:
Human   654 ---------------QQNSVVICDGLGQVVGEYKGPGLH---------GCQPGSVSVDKKGYIFL 694

  Fly  1127 GDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTLYVHXL 1191
            .....|:  |.....:|:|..:|      ::...||:   :..|.|:....:.|:.|:...:| .
Human   695 TLREVNK--VVILDPKGSLLGDF------LTAYHGLE---KPRVTTMVDGRYLVVSLSNGTIHIF 748

  Fly  1192 QIKA 1195
            ::::
Human   749 RVRS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	18/71 (25%)
		BBOX	321..360	CDD:237988	14/38 (37%)
		BBC	369..494	CDD:128778	33/125 (26%)
		NHL_brat_like	913..1186	CDD:271329	38/272 (14%)
		NHL repeat	936..972	CDD:271329	8/35 (23%)
		NHL repeat	983..1025	CDD:271329	2/41 (5%)
		NHL repeat	1028..1064	CDD:271329	6/35 (17%)
		NHL repeat	1068..1107	CDD:271329	6/38 (16%)
		NHL repeat	1112..1151	CDD:271329	7/38 (18%)
		NHL repeat	1157..1183	CDD:271329	5/25 (20%)
TRIM56	NP_112223.1	RAD18	8..>214	CDD:333230	64/257 (25%)
		RING-HC_TRIM56_C-V	19..60	CDD:319498	17/73 (23%)
		RING-HC finger (C3HC4-type)	21..59	CDD:319498	17/64 (27%)
		BBOX	169..205	CDD:237988	14/37 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..484		28/142 (20%)
		NHL	521..748	CDD:302697	67/438 (15%)
		WD40 repeat	593..627	CDD:293791	12/74 (16%)
		NHL repeat	598..626	CDD:271320	8/35 (23%)
		NHL repeat	634..674	CDD:271320	11/71 (15%)
		WD40 repeat	635..672	CDD:293791	11/68 (16%)
		WD40 repeat	681..720	CDD:293791	7/46 (15%)
		NHL repeat	681..714	CDD:271320	6/34 (18%)
		NHL repeat	723..748	CDD:271320	5/27 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIP6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7942
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870