DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and Trim2

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_011238598.1	Gene:	Trim2 / 80890	MGIID:	1933163	Length:	774	Species:	Mus musculus

Alignment Length:	1081	Identity:	198/1081 - (18%)
Similarity:	344/1081 - (31%)	Gaps:	408/1081 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 MIKDGDK---LCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQN 214
            :::..||   :|.:|..|...|::|.|||.|||.|||..:...:::.|
Mouse    38 VVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLS----------------- 85

  Fly   215 RLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDL------SNLESEHIVCTSCKSKEEAIS 273
                    ||||:|.:.|..||:.||..::.:||::|:      ||.|...|
Mouse    86 --------CPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDSSI------------- 129

  Fly   274 RCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTC 338
                                          :|.:|     .:...||:.||.|....:::||.:|
Mouse   130 ------------------------------LETVT-----AVAAGKPLSCPNHDGNVMEFYCQSC 159

  Fly   339 QVPTCNDCLLSDHKGSDH-HYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQS 402
            :...|.:|...:|  ::| ......|.||. :|.|:..|....|:....:.|...:...:.:|.:
Mouse   160 ETAMCRECTEGEH--AEHPTVPLKDVVEQH-KASLQVQLDAVNKRLPEIDSALQFISEIIHQLTN 221

  Fly   403 QHDTVRQQIEDAYKCYKRMLESIKDQMLNEL----GRLHSDRELKIMDLMQSMENTMGKLQHAAQ 463
            |..::...|...:...::.|...|..:|.||    |..|...:.::..|:|..|:    ::..:.
Mouse   222 QKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQES----IKSCSN 282

  Fly   464 FGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDH 528
            |..:|::.....|.||:|..:|.:...|.:|          .|...|.             :.|.
Mouse   283 FTAQALNHGTETEVLLVKKQMSEKLNELADQ----------DFPLHPR-------------ENDQ 324

  Fly   529 IDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQ 593
            :|...:..|:.:.:
Mouse   325 LDFIVETEGLKKSI--------------------------------------------------- 338

  Fly   594 QQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPSS 658
                 ||...::.                                 ||:|.|
Mouse   339 -----HNLGTILT---------------------------------TNAVAS------------- 352

  Fly   659 QQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQL 723
                                               :.....:..:|.::.||
Mouse   353 -----------------------------------ETVATGEGLRQTIIGQP------------- 369

  Fly   724 VAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAVG 788
                                                           .|:|.|..|...:....|
Mouse   370 -----------------------------------------------MSVTITTKDKDGELCKTG 387

  Fly   789 GGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILSGDQRALN 853
                                                .|.:.|...||...:...:||........
Mouse   388 ------------------------------------NAYLTAELSTPDGSVADGEILDNKNGTYE 416

  Fly   854 NLQALAKLGLNNNDFCM-----------PPATSPSLQS--LNPIVGGVEDMGLNNFHAVAAPGTT 905
            .|..:.|.|    ||.:           .|.....::|  ::|...||:       ..|.:||:.
Mouse   417 FLYTVQKEG----DFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVK-------RRVKSPGSG 470

  Fly   906 SV------------VTGRNKATPMQ--IRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHR 956
            .|            .||:.|..|::  :..:.|:.|..||:|.:..|.......:|::||:||..
Mouse   471 HVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQC 535

  Fly   957 IEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRKIA 1021
            :::|...|..|.:||:.|:..|||..|..||| |.:|..::.|..|:  .:.|||..|.|..||.
Mouse   536 VQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAV-HPSGDIIIADYDNK--WVSIFSNDGKFKTKIG 597

  Fly  1022 IRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF--------DCSDYMREPSDIAIR- 1077
            ...:....|::|...|||:.||:.:..||:....|::|..|        ..:..:..|...|:.
Mouse   598 SGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGTLDGPHFAAVNS 662

  Fly  1078 DNDFYVCDFKGHCVAVFQDDGTFLYRI-----GNEKVTCFPNGIDISNAGDVLIGDSHGNRFHVA 1137
            :|:..:.||..|.|.||..:|.|:.:.     ||.:... |.|:.:.:.|::::.|...:|..|
Mouse   663 NNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNA-PTGVAVDSNGNIIVADWGNSRIQV- 725

  Fly  1138 CYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNH 1178
             :...|:..|........:....||.:||:|:||.....||
Mouse   726 -FDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNH 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	22/74 (30%)
		BBOX	321..360	CDD:237988	10/39 (26%)
		BBC	369..494	CDD:128778	26/128 (20%)
		NHL_brat_like	913..1186	CDD:271329	79/282 (28%)
		NHL repeat	936..972	CDD:271329	10/35 (29%)
		NHL repeat	983..1025	CDD:271329	15/41 (37%)
		NHL repeat	1028..1064	CDD:271329	12/43 (28%)
		NHL repeat	1068..1107	CDD:271329	12/44 (27%)
		NHL repeat	1112..1151	CDD:271329	8/38 (21%)
		NHL repeat	1157..1183	CDD:271329	9/22 (41%)
Trim2	XP_011238598.1	RING-HC_TRIM2	46..91	CDD:319681	19/69 (28%)
		Bbox2_TRIM2_C-VII	141..182	CDD:380882	11/42 (26%)
		BBC	187..313	CDD:128778	26/130 (20%)
		IG_FLMN	351..447	CDD:214720	21/243 (9%)
		NHL_TRIM2_like	497..774	CDD:271330	77/275 (28%)
		NHL repeat	515..554	CDD:271330	11/38 (29%)
		NHL repeat	562..601	CDD:271330	15/41 (37%)
		NHL repeat	604..640	CDD:271330	12/35 (34%)
		NHL repeat	648..692	CDD:271330	11/43 (26%)
		NHL repeat	701..741	CDD:271330	8/42 (19%)
		NHL repeat	744..770	CDD:271330	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.880