DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and TRIM45

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_079464.2	Gene:	TRIM45 / 80263	HGNCID:	19018	Length:	580	Species:	Homo sapiens

Alignment Length:	424	Identity:	104/424 - (24%)
Similarity:	186/424 - (43%)	Gaps:	48/424 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SGLMIKDGDKL-CKLCSLRLVMPRILSCLHVFCEDCLQ-----AVVSKDTMSASSPNSCSSSSFD 208
            ||..:.:..|. |.||......||:|.|||..|..||:     :||  |.....|..|...|.|.
Human    17 SGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVV--DIRGGDSDTSSEGSIFQ 79

  Fly   209 GSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNL--ESEHIVCTSCKSKEEA 271
            ..:.::..|.:.|.||||..:..|...|:|||..|::..|.:.|.:|  |.:.:||..|..: |.
Human    80 ELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDR-EV 143

  Fly   272 ISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCF 336
            ..||..|...||:.|..||:..:....|.:|.::||.....    |.||:.||.|.:|.|:.:|.
Human   144 EKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSR----IGKPILCPVHPAEELRLFCE 204

  Fly   337 TCQVPTCNDCLLSD-------------HKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCND 388
            .|..|.|.||::.:             ||..|..:|.....:..|     |.|.:.|.:....|.
Human   205 FCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHV-----EALEEALAQIHIINS 264

  Fly   389 AGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMEN 453
            |          ||.:.:.|...:....:.|.:.:|..:|::|.:|..:.:.:|..:......:|.
Human   265 A----------LQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQ 319

  Fly   454 TMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQC--LNLMEQTPKCDINYQLQFDSKPEMFEQF 516
            .:..::...:|.:..:...:.:|.|:.|.::..:.  ||.::.:.:..:|.:::|..:.:..:..
Human   320 LLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCR 384

  Fly   517 AREMFGKFQTDHIDSSPKKLGMT-QQLQQQQQQQ 549
            ..|::|...|..:|  |.|..:. :.|.:.:::|
Human   385 GYEIYGTINTKEVD--PAKCVLQGEDLHRAREKQ 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	26/77 (34%)
		BBOX	321..360	CDD:237988	14/51 (27%)
		BBC	369..494	CDD:128778	21/126 (17%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
TRIM45	NP_079464.2	BBOX	189..226	CDD:237988	11/36 (31%)
		iSH2_PI3K_IA_R	240..357	CDD:304922	21/131 (16%)
		Filamin	394..497		6/25 (24%)
		Filamin	397..494	CDD:279024	5/22 (23%)
		IG_FLMN	399..497	CDD:214720	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020