DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and Trim42

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_084495.2	Gene:	Trim42 / 78911	MGIID:	1926161	Length:	723	Species:	Mus musculus

Alignment Length:	635	Identity:	120/635 - (18%)
Similarity:	215/635 - (33%)	Gaps:	203/635 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DVTSSSSIGSETSISSTGSTA--IAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHGVTELDSL 145
            :||.:...|...||.::..||  :....|.:|:.               .:...|||.|:.|
Mouse    98 NVTITFRKGRLRSIVTSSKTALRVGSSDTQMDEP---------------KTMPASSHLVSHL--- 144

  Fly   146 EDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGS 210
                          .|.:|:...:...:|.|.|..||.||:.:                     .
Mouse   145 --------------TCPMCNRLRLHSFMLPCNHSLCEKCLRQL---------------------Q 174

  Fly   211 EHQNRLSAVFI-ECPVCKQETPLGPKGIKALPCDYIVTNI--------------LDLSNLESEHI 260
            :|.......|| .||:|.:...:.......||.:|:...:              .|.|   |..|
Mouse   175 KHAEVTENFFILICPMCSRSHCMPYSHQMHLPENYLRGRLTKRYMQQHGYLKWRFDRS---SGPI 236

  Fly   261 VCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQ 325
            :|..|:::..|..||..|...|||.|..|.......::|  |.::...::..:|:.||
Mouse   237 LCQVCRTRRIAYKRCVTCRLNLCNDCLKAFHSDVAMQDH--VFVDTSAEDQDEKICIH------- 292

  Fly   326 HVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAG 390
            |.|..:..||.:.....|..|.::.|.|                       .||:...|.|::..
Mouse   293 HPSSRINEYCRSDNQLLCAFCKIAFHNG-----------------------HDTVSLIDACSERS 334

  Fly   391 SNLGSALTELQSQHDTVRQQIED----------AYKCYKRMLESIKDQMLN---ELGRLHSDREL 442
            :.|.||:.:.::    ||.:|::          ::|..|   |:.:.::.|   :|..:..::|.
Mouse   335 AALFSAIAKFKA----VRYEIDNDLMEFNILKSSFKADK---EAKRKEVRNGFLKLRAILQEKEK 392

  Fly   443 KIMDLMQSME-------------NTM--GKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLM 492
            .||:.::::|             .||  .::.....:.:.|:.:...:.||....|:..|....:
Mouse   393 IIMEQIENLEVSRQKEIEKYVYITTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEEGI 457

  Fly   493 EQTPKCDINYQLQFDSK---PEMFEQFAREMFGKFQTDHIDSSPKKL---GMTQQLQQQQQQQQQ 551
            :.|.:.|  .||:..|.   |..|.:.:..:...|.|     .|||.   |.:...|.....:..
Mouse   458 QNTFRPD--PQLRLHSLHCIPLDFAELSNAIHELFPT-----GPKKACSSGDSLPSQYPIHSEMM 515

  Fly   552 LQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKLQLQQQQQHQHNSNNLI----VGHRGSS 612
            :.::.....|....||.:.:                             |::||    ...:|..
Mouse   516 IARKVTFSTHSFGNQQIYQR-----------------------------SSSLISFNTANDKGKM 551

  Fly   613 SVQ--GRLTSAVFSPISLPSSLQS--SFDGDTNSVMSNFSMMDSPPQPSS 658
            .::  ||..||  :|......|.:  |..|:|           .|||.|:
Mouse   552 GLENYGRAQSA--APAKTTDGLYTYWSATGET-----------QPPQSSN 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	15/72 (21%)
		BBOX	321..360	CDD:237988	8/38 (21%)
		BBC	369..494	CDD:128778	26/152 (17%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
Trim42	NP_084495.2	zf-B_box	285..326	CDD:279037	13/70 (19%)
		iSH2_PI3K_IA_R	<369..452	CDD:304922	14/85 (16%)
		FN3	612..698	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010