DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and RNF208

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001375226.1	Gene:	RNF208 / 727800	HGNCID:	25420	Length:	261	Species:	Homo sapiens

Alignment Length:	192	Identity:	46/192 - (23%)
Similarity:	64/192 - (33%)	Gaps:	69/192 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KGSSNVGSLDVTSSSSIGSETSISSTGSTAIAGPSTLLDDSNSSGLGLVVDVDSNGSSQELSSHG 138
            ||||.:|...|.....:.....:...|.:|.|        ::|:..|..::..:.|     .|:.
Human   100 KGSSELGFPRVAPEDEVIVNQYVIRPGPSASA--------ASSAAAGEPLECPTCG-----HSYN 151

  Fly   139 VTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCS 203
            ||:.                           .||:|||||..||.|||.:.          .||.
Human   152 VTQR---------------------------RPRVLSCLHSVCEQCLQILY----------ESCP 179

  Fly   204 SSSFDGSEHQNRLSAVFIECPVCKQETPL-GPKGIKALPCDYIVTNILDLSNLESEHIVCTS 264
            ...             ||.||.|::||.| ...|:.||     ..|...||.|..|.:...|
Human   180 KYK-------------FISCPTCRRETVLFTDYGLAAL-----AVNTSILSRLPPEALTAPS 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	19/71 (27%)
		BBOX	321..360	CDD:237988
		BBC	369..494	CDD:128778
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
RNF208	NP_001375226.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..106		4/5 (80%)
RNF208	NP_001375226.1	RING-HC_RNF208	140..193	CDD:319473	23/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010