DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and Trim32

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001155254.1	Gene:	Trim32 / 69807	MGIID:	1917057	Length:	655	Species:	Mus musculus

Alignment Length:	1116	Identity:	169/1116 - (15%)
Similarity:	305/1116 - (27%)	Gaps:	546/1116 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SSHGVTELDSLEDSCSGLMIKDGDKLCKLC-------SLRLVMPRILSCLHVFCEDCLQAVVSKD 192
            :||  ..||:|.:...          |.:|       .||   |::|.|.|..|..||:.::
Mouse     7 ASH--LNLDALREVLE----------CPICMESFTEEQLR---PKLLHCGHTICRQCLEKLL--- 53

  Fly   193 TMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLES 257
                       :||.:|           :.||.|.:.|.:  ..:..|..:..|..|:|.:.|
Mouse    54 -----------ASSING-----------VRCPFCSKITRI--TSLTQLTDNLTVLKIIDTAGL-- 92

  Fly   258 EHIVCTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVF 322
                       .||:..      .:|.||..              |:.
Mouse    93 -----------SEAVGL------LMCRGCGR--------------RLP----------------- 109

  Fly   323 CPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCN 387
                     :.:|.:|.|..|..|..:||:...|.  |..|.|.|     ||      ::.|:
Mouse   110 ---------RQFCRSCGVVLCEPCREADHQPPGHC--TLPVKEAA-----EE------RRRDF-- 150

  Fly   388 DAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSME 452
                  |..||.|                                       |||
Mouse   151 ------GEKLTRL---------------------------------------REL---------- 160

  Fly   453 NTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFA 517
              .|:||.          :..::|
Mouse   161 --TGELQR----------RKAALE----------------------------------------- 172

  Fly   518 REMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQH 582
                               |:::.||.               :::...|::.|::::.|::..:.
Mouse   173 -------------------GVSRDLQA---------------RYKAVLQEYGHEERRIQEELARS 203

  Fly   583 QQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNF 647
            ::                                                  .|.|..
Mouse   204 RK--------------------------------------------------FFTGSL------- 211

  Fly   648 SMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTS 712
                             |:.:....|..::|...:.:.:||...:......:.:|....|.:.|:
Mouse   212 -----------------AEVEKSNSQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETA 259

  Fly   713 AQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETM 777
            .:..|:                                                      ||.::
Mouse   260 DEEEPE------------------------------------------------------LTASL 270

  Fly   778 PD--TLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPIT 840
            |.  ||.|...:..|..||:     |:                           ..||...:.:.
Mouse   271 PRELTLQDVELLKVGHVGPL-----QI---------------------------GQAVKKPRTVN 303

  Fly   841 LADILSGDQRALNNLQA---LAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAP 902
            :.|..:|::.|.::..|   ..::.::..:....|..||:.|..:....|::
Mouse   304 MEDSWAGEEGAASSASASVTFREMDMSPEEVAPSPRASPAKQRSSEAASGIQ------------- 355

  Fly   903 GTTSVVTGRNKATPMQIRC----KFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNNHRIEVFDKM 963
                             :|    |.|:.|:..|.||.|....:....|::|||..|:||:||::.
Mouse   356 -----------------QCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADRGNYRIQVFNRK 403

  Fly   964 GALK-----------FQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFM 1017
            |.||           |.....|.:...| .|..|| |:.:|...|.|  :..:.:::::..||.
Mouse   404 GFLKEIRRSPSGIDSFVLSFLGADLPNL-TPLSVA-MNCHGLIGVTD--SYDNSLKVYTMDGHC- 463

  Fly  1018 RKIAIRYIDIVAGLAVTA--KGHIVAVDSVSPTV--FVISEEGELVRWFD-CSDYMREPSDIAIR 1077
              :|.....:.....:||  .|..|..|.....:  |.:.....:|::.. ||         |:|
Mouse   464 --VACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVKYSCLCS---------AVR 517

  Fly  1078 DNDFYVCDFKGHCVAVFQDDGTFL--------------YRIG------------------NEKVT 1110
            .. |..||.:|   .|:...|..|              :.||                  ||...
Mouse   518 PK-FVTCDAEG---TVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQISHFFSENEDFR 578

  Fly  1111 CFPNGIDISNAGDVLIGDSHGNRFHVACYSREGA----LQSEFECPHVKVSRCCGLKITSEGYVV 1171
            |.. |:.:...||:::.||  :|..:..:.:.|.    ::....||       .|:.:|.:|.::
Mouse   579 CIA-GMCVDARGDLIVADS--SRKEILHFPKGGGYSVLIREGLTCP-------VGIALTPKGQLL 633

  Fly  1172 TLAKNNHHVLV 1182
            .|...:|.|.:
Mouse   634 VLDCWDHCVKI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	17/78 (22%)
		BBOX	321..360	CDD:237988	8/38 (21%)
		BBC	369..494	CDD:128778	14/124 (11%)
		NHL_brat_like	913..1186	CDD:271329	71/326 (22%)
		NHL repeat	936..972	CDD:271329	14/46 (30%)
		NHL repeat	983..1025	CDD:271329	10/41 (24%)
		NHL repeat	1028..1064	CDD:271329	7/40 (18%)
		NHL repeat	1068..1107	CDD:271329	11/70 (16%)
		NHL repeat	1112..1151	CDD:271329	7/42 (17%)
		NHL repeat	1157..1183	CDD:271329	6/26 (23%)
Trim32	NP_001155254.1	RING-HC_TRIM32_C-VII	20..66	CDD:319501	16/83 (19%)
		RING-HC finger (C3HC4-type)	21..65	CDD:319501	16/71 (23%)
		Bbox1_TRIM32_C-VII	99..139	CDD:380864	13/81 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..347		4/19 (21%)
		NHL 1	360..403		16/42 (38%)
		NHL_TRIM32_like	364..646	CDD:271331	69/311 (22%)
		NHL repeat	376..416	CDD:271331	13/39 (33%)
		NHL 2	417..460		10/46 (22%)
		NHL repeat	433..472	CDD:271331	10/44 (23%)
		NHL 3	461..501		9/42 (21%)
		NHL repeat	474..514	CDD:271331	7/39 (18%)
		NHL repeat	515..566	CDD:271331	11/54 (20%)
		NHL 4	564..607		9/45 (20%)
		NHL repeat	579..611	CDD:271331	8/34 (24%)
		NHL 5	608..648		9/44 (20%)
		NHL repeat	619..645	CDD:271331	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489543at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010