DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and ftr66

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_690320.2	Gene:	ftr66 / 561829	ZFINID:	ZDB-GENE-070912-661	Length:	545	Species:	Danio rerio

Alignment Length:	331	Identity:	78/331 - (23%)
Similarity:	136/331 - (41%)	Gaps:	65/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 CKLCSLRLVMPRILSCLHVFCEDCLQAVVS-KDTMSASSPNSCSSSSFDGSEHQNRLSAVFIECP 224
            |.:|...|..|..:.|.|.:|..|:....: ||.:...|...|:.:              |...|
Zfish    12 CSICLDLLKDPVAIPCGHSYCMLCINDYWNQKDHLGIFSCPQCAQT--------------FTPRP 62

  Fly   225 VCKQETPLGPKGIK----ALPCDYIVTNILDLSNLESEHIVCTSCKS-KEEAISRCNDCANFLCN 284
            |..:.|.|.....|    .||.:.|.:|.:      ...:.|..|.| |::|:..|..|....|.
Zfish    63 VLNRNTMLADVVNKLRKLELPDEQIYSNFM------PGDVACDFCTSIKQKAVKSCLVCLASYCQ 121

  Fly   285 GCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLS 349
            ....||......:.|.::   :...|:.:|:       ||:| .:.|:.||.|.|...|..|::.
Zfish   122 NHLEAHYKSPALKKHKLI---EALANIQEKI-------CPRH-DKYLEIYCRTDQQCICLLCVMD 175

  Fly   350 DHKGSD-------------------HHYETATVAEQAVRADLEETLSDTLK-KADYCNDAGSNLG 394
            :|||.|                   ..|:....:::....:|::.: |.|| .|....:.|..:.
Zfish   176 EHKGHDVVPGDVESTKKQKELGMTRQKYKLKIHSKEKDLMELKQAV-DALKISAQTAIENGEKIF 239

  Fly   395 SALTE-LQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKL 458
            |.|.: ::.:....|..|.|..|..:.||::: :|.:|||.:  .||||::  |::| |:.:..|
Zfish   240 SELMQSIERRQCKFRDLISDQEKAAESMLQTL-EQEINELKQ--RDRELEM--LLKS-EDQVHVL 298

  Fly   459 QHAAQF 464
            |:.:.|
Zfish   299 QNCSSF 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	15/69 (22%)
		BBOX	321..360	CDD:237988	15/57 (26%)
		BBC	369..494	CDD:128778	28/98 (29%)
		NHL_brat_like	913..1186	CDD:271329
		NHL repeat	936..972	CDD:271329
		NHL repeat	983..1025	CDD:271329
		NHL repeat	1028..1064	CDD:271329
		NHL repeat	1068..1107	CDD:271329
		NHL repeat	1112..1151	CDD:271329
		NHL repeat	1157..1183	CDD:271329
ftr66	XP_690320.2	RING	12..54	CDD:302633	11/41 (27%)
		zf-B_box	146..184	CDD:279037	15/45 (33%)
		Phasin	<218..290	CDD:298582	22/77 (29%)
		SPRY_PRY_SNTX	364..542	CDD:294002
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100