DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mei-P26 and trim2b

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	XP_009304581.1	Gene:	trim2b / 558046	ZFINID:	ZDB-GENE-090312-70	Length:	669	Species:	Danio rerio

Alignment Length:	898	Identity:	167/898 - (18%)
Similarity:	286/898 - (31%)	Gaps:	305/898 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 VFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADY 385
            :.|.||..:....||..|:...|.||:..:|  ::|..::...|.....|.|::.:.....:...
Zfish    28 LICSQHKGKVSALYCLVCENAVCEDCMNGEH--AEHPTDSLEKAVDQQLAALQDKVDSAKNRLPQ 90

  Fly   386 CNDAGSNLGSALTELQSQHDTVRQQIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQS 450
            ..:|...|...|.:|.||..::.:.|..::....:.|::.|..:|.||
Zfish    91 IREAVQYLREILQQLNSQRSSIEEDIHSSFSELHKTLDTRKSVLLMEL----------------- 138

  Fly   451 MENTMGKLQHAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQ 515
             |.|.|                      |.:.::.||...|:::  :..|||.....|
Zfish   139 -EVTYG----------------------LKQKVLQAQLDTLLQE--ESAINYNCSLTS------- 171

  Fly   516 FAREMFGKFQTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQV 580
                       :.:|...|    ...||..::..::|
Zfish   172 -----------EALDGGSK----ASVLQAHKEAGERL---------------------------- 193

  Fly   581 QHQQQQQKLQLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMS 645
                                         |..|.||
Zfish   194 -----------------------------GDLSSQG----------------------------- 200

  Fly   646 NFSMMDSPPQPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQP 710
                  .|.||....||.                   ::.:::..:|.             :|
Zfish   201 ------LPLQPEENDQLD-------------------LMMEIEGLRKS-------------IH-- 225

  Fly   711 TSAQSMPQQLGQLVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTE 775
                    .||.:|....:                                         ||.||
Zfish   226 --------NLGTIVTTNAV-----------------------------------------ASQTE 241

  Fly   776 TMPDTLNDALAVGGGAAGPVPNVVAQVPGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPIT 840
            ...|.|...:.   |....|........||...||.|::.              |...||...|.
Zfish   242 ASGDGLEQCIV---GQPASVIITTRDKAGGLCKTGNAIIS--------------AEVYTPDGSIA 289

  Fly   841 ---LADILSGDQ------RALNNLQALAKL---GLNNNDFCMPPATSP-----SLQSLNPIVGGV 888
               :.|:.:|..      :...|.....:|   .:..:.|.:..::||     :..:.|....|.
Zfish   290 DGEIVDMKNGTYEFQYTVKKEGNFSLALRLYDQHIKGSPFQLKVSSSPDDSPTTTTAANAASTGS 354

  Fly   889 EDMGLNNFHAVAAPGTTS-----------VVTGRNKATPMQ--IRCKFGSLGTAKGQFNSPHGFC 940
            .|.|... .:..:||:.|           ..|.:.:..|::  :..:.|:.|..||:|.:..|..
Zfish   355 SDGGARK-RSAKSPGSRSRQKGVRRGGSLFSTPKKRVNPIEDDLIFRIGTKGRNKGEFTNLQGVA 418

  Fly   941 LGVDEEIIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERS 1005
            ...:..|::||:||..:::|...|..:.:|||.|:..|||..|..||| |.||..::.|..|:
Zfish   419 ACSEGRILIADSNNQCVQIFSNTGEFQSRFGVRGRSPGQLQRPTGVAV-HPNGDIIIADYDNK-- 480

  Fly  1006 RMQIFSKCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF----DCSD 1066
            .:.|||..|.:..|:....:....|::|...||::.||:.:.|||:....|:|:..|    :...
Zfish   481 WVSIFSSEGKYKAKLGSGRLMGPKGVSVDQNGHVIVVDNKACTVFIFQPSGKLITKFGSRGNGDR 545

  Fly  1067 YMREPSDIAI-RDNDFYVCDFKGHCVAVFQDDGTFLYRI-----GNEKVTCFPNGIDISNAGDVL 1125
            ....|...|: .:|:..:.||..|.|.||..||.||.:.     ||.:... |.|:.:...|:::
Zfish   546 QFAGPHFAAVNNNNEIIITDFHNHSVKVFNADGEFLLKFGSNGEGNGQFNA-PTGVAVDVNGNII 609

  Fly  1126 IGDSHGNRFHVACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNH 1178
            :.|...:|..|  :...|:..|........:....||.:||:|:||.....||
Zfish   610 VADWGNSRIQV--FDGSGSFLSYINTAADPLYGPQGLALTSDGHVVVADSGNH 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325
		BBOX	321..360	CDD:237988	11/38 (29%)
		BBC	369..494	CDD:128778	21/124 (17%)
		NHL_brat_like	913..1186	CDD:271329	79/278 (28%)
		NHL repeat	936..972	CDD:271329	9/35 (26%)
		NHL repeat	983..1025	CDD:271329	14/41 (34%)
		NHL repeat	1028..1064	CDD:271329	12/39 (31%)
		NHL repeat	1068..1107	CDD:271329	14/44 (32%)
		NHL repeat	1112..1151	CDD:271329	8/38 (21%)
		NHL repeat	1157..1183	CDD:271329	9/22 (41%)
trim2b	XP_009304581.1	zf-B_box	29..66	CDD:279037	11/38 (29%)
		iSH2_PI3K_IA_R	73..199	CDD:304922	32/246 (13%)
		IG_FLMN	237..334	CDD:214720	22/113 (19%)
		Filamin	237..329	CDD:279024	21/108 (19%)
		NHL_TRIM2_like	396..669	CDD:271330	78/271 (29%)
		NHL repeat	414..453	CDD:271330	11/38 (29%)
		YncE	415..>660	CDD:225926	71/250 (28%)
		NHL repeat	461..500	CDD:271330	14/41 (34%)
		NHL repeat	503..540	CDD:271330	12/36 (33%)
		NHL repeat	547..588	CDD:271330	13/40 (33%)
		NHL repeat	594..636	CDD:271330	8/44 (18%)
		NHL repeat	639..665	CDD:271330	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920