DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mei-P26 and trim45

DIOPT Version :9

Sequence 1:NP_001356936.1 Gene:mei-P26 / 45775 FlyBaseID:FBgn0026206 Length:1310 Species:Drosophila melanogaster
Sequence 2:NP_001011026.1 Gene:trim45 / 496435 XenbaseID:XB-GENE-997848 Length:547 Species:Xenopus tropicalis


Alignment Length:415 Identity:99/415 - (23%)
Similarity:158/415 - (38%) Gaps:96/415 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 NGSSQELSSHGVTELDSLEDSCSGLMIKDGDKLCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKD 192
            |||.:|  :.|.|:                   |..|......||||.|||..|..||..:    
 Frog     4 NGSRKE--AQGRTQ-------------------CPQCQQPFCQPRILPCLHTLCGGCLAKL---- 43

  Fly   193 TMSASSPNSCSSSSFDGSEHQNRLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLES 257
                 .|.|..........|.:.|      ||||..|..|...|::.|..|::....:.|:.::|
 Frog    44 -----EPFSALGKGHSAGTHWSVL------CPVCDSEVALPAGGVEELLPDWLAEAEVLLAQVQS 97

  Fly   258 EHIV--CTSCKSKEEAISRCNDCANFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKP 320
            ..:.  |..|: :.:|..||.:|...:|..|..||:..:....|.:..::||:...    |:...
 Frog    98 GGLALPCDLCR-EGQAEKRCQECKVNVCEFCCQAHRRQKRTAAHPLHPLQDLSLGT----ILPPA 157

  Fly   321 VFCPQHVSENLKYYCFTCQVPTCNDCLLSDHKGSD---------HHYETATVAEQAVRADLEETL 376
            ..|..|..|.|..:|..|.||.|.||.:..|:|.|         .|.|:...|.|.....:|:  
 Frog   158 PCCTLHPLEALGLFCEPCTVPCCRDCAIGHHRGHDLRPAAECAGGHRESLLRALQEAEPHIEQ-- 220

  Fly   377 SDTLKKA-DYCNDAGSNLGSALTELQSQHDT-----VR----------QQIEDAYKCYKRMLESI 425
               |:.| ....:||..||.....|:::.:.     ||          :.||:..:..:::|...
 Frog   221 ---LEAALGGVQEAGKALGQRALGLRAEVEAFIEGYVRAVLEHKAALLRDIEEETQRRQQVLALR 282

  Fly   426 KDQMLNELGRLHS----DRELKI----MDLMQSMENTMGKLQHAAQFGQRAVDKAN--SIEFLLL 480
            |.|:..:|..|.:    .|:|..    :.|:|:....:.:|:...|...||.|:.|  .|:|   
 Frog   283 KAQLQQQLLDLRTASGFTRDLVARGPDLHLLQAQGLALTRLKELNQGAPRAADQNNPAGIQF--- 344

  Fly   481 KPIISAQCLNLMEQTPKCDINYQLQ 505
                     :..|:...|. .||:|
 Frog   345 ---------SPWEEAGLCQ-GYQMQ 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mei-P26NP_001356936.1 RING_Ubox 158..230 CDD:354325 20/71 (28%)
BBOX 321..360 CDD:237988 15/47 (32%)
BBC 369..494 CDD:128778 29/150 (19%)
NHL_brat_like 913..1186 CDD:271329
NHL repeat 936..972 CDD:271329
NHL repeat 983..1025 CDD:271329
NHL repeat 1028..1064 CDD:271329
NHL repeat 1068..1107 CDD:271329
NHL repeat 1112..1151 CDD:271329
NHL repeat 1157..1183 CDD:271329
trim45NP_001011026.1 RING-HC_TRIM45-C-VII 14..69 CDD:319502 21/88 (24%)
Bbox1_TRIM45_C-X 102..145 CDD:380867 11/43 (26%)
zf-B_box 155..195 CDD:395518 14/39 (36%)
BBC 203..>279 CDD:128778 16/80 (20%)
Filamin 366..461 CDD:395505
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D489543at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR25462
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.110

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