DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and trim2

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001005680.1	Gene:	trim2 / 448181	XenbaseID:	XB-GENE-942459	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	1083	Identity:	204/1083 - (18%)
Similarity:	358/1083 - (33%)	Gaps:	400/1083 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 MIKDGDK---LCKLCSLRLVMPRILSCLHVFCEDCLQAVVSKDTMSASSPNSCSSSSFDGSEHQN 214
            :::..||   :|.:|..|...|::|.|||.|||.|||..:...:::.|
Frog    12 VVRQIDKQFLICSICLDRYKNPKVLPCLHTFCERCLQNYIPAHSLTLS----------------- 59

  Fly   215 RLSAVFIECPVCKQETPLGPKGIKALPCDYIVTNILDLSNLESEHIVCTSCKSKEEAISRCNDCA 279
                    ||||:|.:.|..||:.||..::.:||::|:                   :.|..|
Frog    60 --------CPVCRQTSILPEKGVSALQNNFFITNLMDV-------------------LQRSPD-- 95

  Fly   280 NFLCNGCDNAHKYMRCFENHHVVRIEDLTKNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCN 344
                ||.:.:                .:.:.| ..:...||:.||.|....:::||.:|:...|.
Frog    96 ----NGIEES----------------SILETV-SAVAAGKPLSCPNHDGNVMEFYCQSCETAMCQ 139

  Fly   345 DCLLSDHKGSDHHYETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSALTELQSQHDTVRQ 409
            ||.      ...|.|..||           .|.|.:::..             ..||:|.|.|::
Frog   140 DCT------GGEHAEHPTV-----------PLKDVVEQHK-------------AALQAQLDAVKK 174

  Fly   410 ---QIEDAYKCYKRMLESIKDQMLNELGRLHSDRELKIMDLMQSMENTMGKLQHAAQFGQRAVDK 471
               :|:.|.:|...::..:..|..:.:..:||..:    ||.:::.
Frog   175 RLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFD----DLQKTLN------------------- 216

  Fly   472 ANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKFQTDHIDSSPKKL 536
                   :.|.::      |||    .::||.|
Frog   217 -------VRKSVL------LME----LEVNYGL-------------------------------- 232

  Fly   537 GMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQK---------QQVQHQQQQQKLQLQ 592
                                   :|:|.|.|.....:.|:.         |.:.|..:.:.|.::
Frog   233 -----------------------KHKVLQAQLDTLIEGQESIKSCTTFTAQALNHGTETEVLLVK 274

  Fly   593 QQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPPQPS 657
            :|...:                                             ::..:..|.|.||.
Frog   275 KQMSDK---------------------------------------------LNELAEQDFPLQPH 294

  Fly   658 SQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQLGQ 722
            ...||                                ...|:.:..::.:|          .||.
Frog   295 ENDQL--------------------------------DFIVETEGLKKSIH----------NLGT 317

  Fly   723 LVAPQGIVQQAGHVNLNAGPGPNISINGLGAGGPPPSFSMLEYNISRLASLTETMPDTLNDALAV 787
            ::....:..:    .:..|.|...|:                  |.:..|:|.|..|...:....
Frog   318 ILTTNAVASE----TVATGEGLRQSV------------------IGQPMSVTITTKDKDGELCKT 360

  Fly   788 GGGAAGPVPNVVAQV--PGGSAVTGAAVVGASHAHQQQSQAVMPASAVTPTQPITLADILSGDQR 850
            |..      .:.|::  |.||...|..|...:..::        .|...||:......:...||.
Frog   361 GSA------YISAELFTPDGSVTDGEVVDNKNGTYE--------FSYTIPTEGDFTLSLRLYDQH 411

  Fly   851 ALNNLQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVEDMGLNNFHAVAAPGTTSV-------- 907
                        :..:.|.:....|   ..::|...||:       ..|.:||:..|
Frog   412 ------------IKGSPFKLKVVKS---ADVSPTTEGVK-------RRVKSPGSGHVKQKAVKRP 454

  Fly   908 ----VTGRNKATPMQ--------------IRCKFGSLGTAKGQFNSPHGFCLGVDEEIIVADTNN 954
                .||:.|..|::              :|...|:.|..||:|.:..|.....:.:|::||:||
Frog   455 ASMYSTGKRKENPIEDDLIFRVGSRKDEDVRSLTGTKGRNKGEFTNLQGVAASTNGKILIADSNN 519

  Fly   955 HRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFSKCGHFMRK 1019
            ..:::|...|..|.:||:.|:..|||..|..||| |.:|..::.|..|:  .:.|||..|.|..|
Frog   520 QCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAV-HPSGDIIIADYDNK--WVSIFSADGKFKTK 581

  Fly  1020 IAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWF--------DCSDYMREPSDIAI 1076
            |....:....|::|...|||:.||:.:..||:....|::|..|        ..:..:..|...|:
Frog   582 IGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDKQFAGTLDGPHFAAV 646

  Fly  1077 R-DNDFYVCDFKGHCVAVFQDDGTFLYRI-----GNEKVTCFPNGIDISNAGDVLIGDSHGNRFH 1135
            . :|:..|.||..|.|.||..||.|:.:.     ||.:... |.|:.:.:.|::::.|...:|..
Frog   647 NSNNEIIVTDFHNHSVKVFNQDGEFILKFGSNGEGNGQFNA-PTGVAVDSNGNIIVADWGNSRIQ 710

  Fly  1136 VACYSREGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNH 1178
            |  :...|:..|........:....||.:||:|:||.....||
Frog   711 V--FDGSGSFLSYINTSADPLYGPQGLSLTSDGHVVVADSGNH 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	22/74 (30%)
		BBOX	321..360	CDD:237988	10/38 (26%)
		BBC	369..494	CDD:128778	18/127 (14%)
		NHL_brat_like	913..1186	CDD:271329	82/294 (28%)
		NHL repeat	936..972	CDD:271329	10/35 (29%)
		NHL repeat	983..1025	CDD:271329	15/41 (37%)
		NHL repeat	1028..1064	CDD:271329	12/43 (28%)
		NHL repeat	1068..1107	CDD:271329	14/44 (32%)
		NHL repeat	1112..1151	CDD:271329	8/38 (21%)
		NHL repeat	1157..1183	CDD:271329	9/22 (41%)
trim2	NP_001005680.1	RING	23..66	CDD:238093	19/67 (28%)
		BBOX	113..154	CDD:197662	15/57 (26%)
		BBC	161..287	CDD:128778	29/278 (10%)
		IG_FLMN	325..421	CDD:214720	21/143 (15%)
		Filamin	325..418	CDD:279024	20/140 (14%)
		NHL_TRIM2_like	483..760	CDD:271330	80/275 (29%)
		NHL repeat	501..540	CDD:271330	11/38 (29%)
		YncE	547..>751	CDD:225926	57/209 (27%)
		NHL repeat	548..587	CDD:271330	15/41 (37%)
		NHL repeat	590..627	CDD:271330	12/36 (33%)
		NHL repeat	634..679	CDD:271330	13/44 (30%)
		NHL repeat	685..727	CDD:271330	8/44 (18%)
		NHL repeat	730..756	CDD:271330	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920