DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mei-P26 and wech

DIOPT Version :9

Sequence 1:	NP_001356936.1	Gene:	mei-P26 / 45775	FlyBaseID:	FBgn0026206	Length:	1310	Species:	Drosophila melanogaster
Sequence 2:	NP_001137614.1	Gene:	wech / 44653	FlyBaseID:	FBgn0259745	Length:	832	Species:	Drosophila melanogaster

Alignment Length:	1103	Identity:	210/1103 - (19%)
Similarity:	336/1103 - (30%)	Gaps:	430/1103 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 VVSKDTMSASSPNSCSSSSFDGSEHQNRLSAVFIEC-PVCKQETPLGPKGIKALP--CDYIVTNI 249
            |....|.:.|...|.||::.:.||   ||.|..:|. |.......|.|...::.|  .|:.:.|.
  Fly    25 VAHSSTANGSGGGSVSSNASNSSE---RLLAGILESFPAWDLNVGLLPNVGQSSPPRADFFINNF 86

  Fly   250 L-------DLS--------------NLESEHIVCTSCKSKEEAIS-RCNDCANFLCNGCDNAHKY 292
            |       |.|              :.||.:....||...|.:.| ||.:|..|:||.|...|:.
  Fly    87 LGGLDTHGDFSIGPIGSGARSNPKMSPESSNNSSISCGWCEVSASIRCLECNEFMCNDCLREHRN 151

  Fly   293 MRCFENHHVVRIEDLT-------KNVHDKLIIHKPVFCPQHVSENLKYYCFTCQVPTCNDCLLSD 350
            .....||.:|.:....       .:|:.:........|..| :|.|:|.|..|:...|..|.|.:
  Fly   152 SPLSSNHSIVSLPTPIGASPTGGSSVNAQTPPSGNFICDIH-NEMLRYVCDYCRKLVCQCCTLHE 215

  Fly   351 HKGSDHHY------------------ETATVAEQAVRADLEETLSDTLKKADYCNDAGSNLGSAL 397
            ||  :|.|                  |::.|..:.:::.:::.|:........|::...|:
  Fly   216 HK--EHSYASIQSFMVGSKEKLEGAIESSQVGTRCIKSSIDKALAFIRLIERNCSELSDNI---- 274

  Fly   398 TELQSQHDTVRQQIEDAYKCYKRMLESIKDQ---MLNELGRLHSDRELKIMDLMQSMENTMGKLQ 459
                             .|.:::.:.:|:|:   :|:.:.:|...|...:.|.|..:::.:..|.
  Fly   275 -----------------RKAFRQFIIAIEDRERFLLDFVEKLRQRRLAILHDQMAGLKSALAGLS 322

  Fly   460 HAAQFGQRAVDKANSIEFLLLKPIISAQCLNLMEQTPKCDINYQLQFDSKPEMFEQFAREMFGKF 524
            ..:....:..|.|.:::                      .|...::..:.....||||
  Fly   323 ETSDMLSKVADNACNMD----------------------QIEIAMKLTNGQRQMEQFA------- 358

  Fly   525 QTDHIDSSPKKLGMTQQLQQQQQQQQQLQQQQHQHQHQVQQQQHHHQQQQQQKQQVQHQQQQQKL 589
                        |:.:.||.:|:
  Fly   359 ------------GIYKDLQPKQE------------------------------------------ 369

  Fly   590 QLQQQQQHQHNSNNLIVGHRGSSSVQGRLTSAVFSPISLPSSLQSSFDGDTNSVMSNFSMMDSPP 654
                                            ||:                          .:||
  Fly   370 --------------------------------VFA--------------------------FAPP 376

  Fly   655 QPSSQQQLPSAQQQSQQQQQQQQQQQAVVLQQVQQQQKHQQHQVQQQQQQQVLHQPTSAQSMPQQ 719
            ..|..|.:              :.|..|:|..                              .:.
  Fly   377 DYSLLQDI--------------RNQGGVILVD------------------------------DKN 397

  Fly   720 LGQLVAPQGIVQQAGHVNLNAGPGPNI------SINGLG-AGGPPPSFSMLEYNISRLASLTETM 777
            |..:.:..|||.....||..|.....:      .:.|:| :.|...:|.|             .|
  Fly   398 LPIVSSSNGIVPSVSSVNAVAAASVGVVGGVAGVVGGVGVSNGLDLAFGM-------------NM 449

  Fly   778 PDTLNDALAVGGGA---------AGPVPNVVAQVPGGSAVTGAAVVGASHA------HQQQSQAV 827
            |   |:.|:|...:         :..:|:.:.|..||||...::  |.|.|      :..:|...
  Fly   450 P---NNPLSVASSSVRRPLLRDNSFRIPSPIMQPRGGSACGMSS--GMSSAALDWELNGLRSSPG 509

  Fly   828 MPASAVTPTQPITLADILSGDQRALNNLQALAKLGLNNNDFCMPPATSPSLQSLNPIVGGVED-- 890
            :..||...||             |:.....|.|: .|:|...:..||.           |.||
  Fly   510 LHFSAPRTTQ-------------AIPGCMDLVKV-RNSNALSLSFATE-----------GHEDGQ 549

  Fly   891 ----MGLNNFHAVAAPGTTSVVTGRNKATPM-----QIRCKFGSLGTAKGQFNSPHGFCLGVDEE 946
                .||    .|...|...|...||....:     .::.|||..|...|:|:.|.|.|:.||..
  Fly   550 VSRPWGL----CVDKMGHVLVSDRRNNRVQVFNPDGSLKFKFGRKGVGNGEFDLPAGICVDVDNR 610

  Fly   947 IIVADTNNHRIEVFDKMGALKFQFGVAGKEEGQLWYPRKVAVMHNNGKFVVCDRGNERSRMQIFS 1011
            |||.|.:|||:::|...|....:||..|||.||..||..||| ::..:.||.|..|.  |:|.|.
  Fly   611 IIVVDKDNHRVQIFTASGVFLLKFGSYGKEYGQFQYPWDVAV-NSRRQIVVTDSRNH--RIQQFD 672

  Fly  1012 KCGHFMRKIAIRYIDIVAGLAVTAKGHIVAVDSVSPTVFVISEEGELVRWFDCSDYMREPSDIAI 1076
            ..|.|:|:|.........|:|             ||.....:..|.::
  Fly   673 SEGRFIRQIVFDNHGQTKGIA-------------SPRGVCYTPTGNII----------------- 707

  Fly  1077 RDNDFYVCDFKGHCVAVFQDDGTFLYRIGNEKVTCFPNGIDISNAGDVLIGDSH-GNRFHVACYS 1140
                  |.||..||:.:...|                       ..|:|....| |:.||
  Fly   708 ------VSDFDNHCLYLIDPD-----------------------INDILSVKGHEGSGFH----- 738

  Fly  1141 REGALQSEFECPHVKVSRCCGLKITSEGYVVTLAKNNHHVLVLNTLYVHXLQIKARNNRPSVD 1203
                   ||..|.   ..||    ..||.::.....|..:||.|..... ..|:.   |||::
  Fly   739 -------EFNRPS---GLCC----DDEGRIIVADSKNQRILVFNQNLDFMWDIEV---RPSIN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mei-P26	NP_001356936.1	RING_Ubox	158..230	CDD:354325	13/42 (31%)
		BBOX	321..360	CDD:237988	14/56 (25%)
		BBC	369..494	CDD:128778	14/127 (11%)
		NHL_brat_like	913..1186	CDD:271329	71/278 (26%)
		NHL repeat	936..972	CDD:271329	15/35 (43%)
		NHL repeat	983..1025	CDD:271329	15/41 (37%)
		NHL repeat	1028..1064	CDD:271329	5/35 (14%)
		NHL repeat	1068..1107	CDD:271329	6/38 (16%)
		NHL repeat	1112..1151	CDD:271329	8/39 (21%)
		NHL repeat	1157..1183	CDD:271329	6/25 (24%)
wech	NP_001137614.1	BBOX	187..224	CDD:237988	14/39 (36%)
		iSH2_PI3K_IA_R	232..343	CDD:304922	17/153 (11%)
		YncE	<527..>740	CDD:225926	76/302 (25%)
		NHL_TRIM71_like	528..810	CDD:271324	90/357 (25%)
		NHL repeat	553..592	CDD:271324	10/42 (24%)
		NHL repeat	600..639	CDD:271324	16/38 (42%)
		WD40 repeat	603..640	CDD:293791	15/36 (42%)
		WD40 repeat	647..684	CDD:293791	15/39 (38%)
		NHL repeat	647..683	CDD:271324	15/38 (39%)
		WD40 repeat	692..736	CDD:293791	14/102 (14%)
		NHL repeat	692..733	CDD:271324	12/99 (12%)
		NHL repeat	742..772	CDD:271324	9/36 (25%)
		WD40 repeat	743..767	CDD:293791	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133242at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850